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The Variant: Brain & Cognition

Posts about Brain & Cognition from The Variant, Varia's genomic publication.

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Research Watch Brain & Cognition

COMT Val158Met (rs4680): what does the research actually support?

A plain-language survey of COMT Val158Met (rs4680), one of the most studied and most over-interpreted common variants in behavioral genetics. It is not in the Varia Genome Catalog, and this post explains why the evidence reads as open questions rather than conclusions.

Catalog explainer Brain & Cognition

What does the APOE e4/e4 genotype mean?

A plain-language explainer of the APOE e4/e4 diplotype, the highest common genetic risk configuration for late-onset Alzheimer's disease in Varia's curated catalog.