Institutional Authorities

What This Page Is and Is Not

Varia's current retained catalog covers 64 variants across 6 health areas (full accepted list), but not every claim on those pages comes from Varia alone. Where an institutional framework already exists, Varia cites it directly instead of manufacturing a second authority layer. This page makes that authority chain visible.

It is not a list of experts, not a commercial affiliation page, and not a substitute for the Sources page. The Sources page is broader. This page is narrower and focuses on the institutional bodies that Varia routes to most directly.

Clinical Genome Resource

ClinGen is a clinical genomics authority that curates gene-disease validity and actionability frameworks. In Varia's grading framework, ClinGen is one of the named institutional surfaces that Varia cites directly rather than re-grading through a separate house label.

Varia's pathogenic-finding panel has a place for ClinGen Gene-Disease Validity and ClinGen Actionability labels, shown as ClinGen issued them rather than re-graded. No variant in the current catalog carries a ClinGen label, so none appears in results today; when one does, it will be shown as ClinGen's, not as a Varia grade.

• Why Varia names it: ClinGen is the named authority for gene-disease validity and actionability, so it is where those labels would come from.
• Reference URL: https://clinicalgenome.org/

ClinPGx

ClinPGx is the consolidated pharmacogenomics platform that absorbed CPIC and PharmGKB content in March 2026. Varia queries guideline and clinical-annotation levels through the ClinPGx REST API at api.clinpgx.org and watches GitHub releases on clinpgx/clinpgx-data for schema and content updates on a documented detector schedule.

• Why Varia uses it: ClinPGx is the post-migration canonical API for CPIC guideline levels and PharmGKB clinical annotations.
• Link and identity verified: 2026-10-19
• Reference URL: https://www.clinpgx.org/ (API: https://api.clinpgx.org/)

Clinical Pharmacogenetics Implementation Consortium

CPIC publishes pharmacogenomic guidelines that translate genotype information into drug-response interpretation. Varia treats CPIC levels as authority-surfaced outputs for pharmacogenomic findings rather than as material for a second Varia-made grade. Since the March 2026 ClinPGx migration, Varia reads CPIC guideline data through ClinPGx; the legacy cpicpgx.org site redirects to ClinPGx.

Varia uses CPIC to populate pharmacogenomic authority panels, to name the relevant drug-gene pair, and to drive weekly and event-driven detector checks for guideline changes. When Varia talks about medication-response evidence, CPIC is one of the first named authorities in that chain.

• Why Varia uses it: Varia uses CPIC because it routes pharmacogenomic interpretation through established clinical guideline levels instead of a parallel in-house framework.
• Link and identity verified: 2026-10-20
• Reference URL: https://www.clinpgx.org/ (CPIC content; legacy cpicpgx.org redirects)

ClinVar

ClinVar is the NCBI archive that aggregates variant classifications, review status, and submission-level disagreement around clinically interpreted variants. Varia uses ClinVar as the public authority surface for ClinVar germline classification and for conflict-aware review-status chips.

Varia uses ClinVar VCV records, raw review-status text, and conflict-aware labels when a pathogenic finding is eligible to surface with authority chrome. ClinVar also feeds the weekly change-detection workflow through variant-summary and submission-summary monitoring.

• Why Varia uses it: Varia uses ClinVar because it is the named public archive behind pathogenic classification surfacing and review-status transparency.
• Link and identity verified: 2026-10-19
• Reference URL: https://www.ncbi.nlm.nih.gov/clinvar/

American College of Medical Genetics and Genomics

ACMG is the professional body that publishes the ACMG/AMP sequence-variant interpretation standard. Varia does not display that standard's name as the grade on a finding card. Pathogenic-class cards show ClinVar germline classification, which ClinVar submitters often produce using ACMG/AMP criteria.

Varia names ACMG as a consulted institution, not as the label on the card. The displayed classification is ClinVar's. Editorial Standards and Methodology explain why Varia does not invent a second pathogenicity score.

• Why Varia uses it: Varia uses ACMG because the rare-variant surface needs a recognized clinical classification framework instead of solo editorial invention.
• Link and identity verified: 2026-10-19
• Reference URL: https://www.acmg.net/

PharmGKB

PharmGKB is a pharmacogenomics knowledge base that publishes clinical annotation levels and structured drug-gene evidence. Varia names PharmGKB alongside CPIC as one of the authorities it consults for pharmacogenomic surfacing. Post-migration, Varia queries PharmGKB clinical annotation levels through the ClinPGx API.

Varia uses PharmGKB clinical annotation levels to complement CPIC guideline levels and to make the medication-response evidence chain more legible on public pages and product surfaces. PharmGKB sits on the ClinPGx monthly detector schedule for authority updates.

• Why Varia uses it: Varia uses PharmGKB because its clinical annotation levels strengthen the pharmacogenomic authority chain Varia makes public.
• Link and identity verified: 2026-10-20
• Reference URL: https://www.pharmgkb.org/ (API access via api.clinpgx.org)

Pharmacogene Variation Consortium

PharmVar maintains star-allele nomenclature and release cadence for pharmacogene haplotype sets, including CYP2C19, CYP2C9, and complex genes such as CYP2D6.

Varia reads single pharmacogene positions, such as CYP2C19 *2 and *17 and CYP2C9 *3, and names the star allele each one defines. It does not call full star-allele haplotypes, and the catalog holds no CYP2D6 variant, so Varia shows no CYP2D6 result. A release-watch detector checks PharmVar for new releases on a regular schedule.

• Why Varia uses it: Varia uses PharmVar because star-allele names have to stay current with the body that assigns them.
• Link and identity verified: 2026-10-19
• Reference URL: https://www.pharmvar.org/

Closing Note

This page exists so readers can inspect the named authorities behind Varia's most consequential surfaces. The broader source landscape lives on the Sources page, and the rules that govern when Varia cites those bodies live on the Editorial Standards page. The higher-level product explanation remains on the Methodology page.