What does Factor V Leiden (rs6025) mean?
A plain-language explainer of Factor V Leiden (rs6025), the most common inherited blood-clotting variant, which Varia reads from your raw DNA file under Heart and Lipids.
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Polygenic risk scores: what the evidence actually supports
Polygenic risk scores are having a moment in consumer genomics. Here is what the published evidence actually supports, where they help, and why Varia explains them without ever printing a personal risk number.
What does MTHFR (C677T and A1298C) mean?
A plain-language explainer of the two common MTHFR variants, C677T (rs1801133) and A1298C (rs1801131), in the folate-processing gene, which Varia reads under Metabolism and Longevity.
COMT Val158Met (rs4680): what does the research actually support?
A plain-language survey of COMT Val158Met (rs4680), one of the most studied and most over-interpreted common variants in behavioral genetics. It is not in the Varia Genome Catalog, and this post explains why the evidence reads as open questions rather than conclusions.
What does the APOE e4/e4 genotype mean?
A plain-language explainer of the APOE e4/e4 diplotype, the highest common genetic risk configuration for late-onset Alzheimer's disease in Varia's curated catalog.