Variant Catalog

Peer-reviewed-backed variants Varia scans for · Updated monthly · Last updated August 2026

What Varia Reports Today and Why Monthly Updates Matter

A re-scan is more than the same report again

Every month, Varia reviews newly published literature and adds, updates, or retires variant interpretations across every area Varia curates. A re-scan against the updated database can return findings that did not exist in your original report. A variant you carry might be newly classified as actionable, or a previous interpretation might be refined or retired based on new evidence.

This is the current accepted list: variants with peer-reviewed evidence strong enough for Varia to scan your file and report a finding. The roster is generated from the same database the scanner uses, so it always matches what a scan can return.

The catalog grows as the science does. Variants we track but do not yet report sit in the Pipeline / Watchlist below, with a plain explanation of why they are held.

Authority reclassifications

Catalog-level broadcast, not a per-person email. Observation starts 2026-06-01.

2026-10-20: rs9923231 PharmGKB annotation level changed from 3 to 1A. Correction on Varia's side: Varia had stored the PharmGKB annotation for a different drug; PharmGKB itself did not change its level.
2026-10-20: rs4244285 PharmGKB annotation level changed from 3 to 1A. Correction on Varia's side: Varia had stored the PharmGKB annotation for a different drug; PharmGKB itself did not change its level.
2026-10-20: rs4149056 PharmGKB annotation level changed from 3 to 1A. Correction on Varia's side: Varia had stored the PharmGKB annotation for a different drug; PharmGKB itself did not change its level.
2026-10-20: rs12248560 PharmGKB annotation level changed from 3 to 1A. Correction on Varia's side: Varia had stored the PharmGKB annotation for a different drug; PharmGKB itself did not change its level.
2026-10-20: rs1057910 PharmGKB annotation level changed from 3 to 1A. Correction on Varia's side: Varia had stored the PharmGKB annotation for a different drug; PharmGKB itself did not change its level.
2026-08-18: rs1799963 ClinVar germline classification changed from Likely Pathogenic to Pathogenic. Correction on Varia's side: Varia fixed which ClinVar record it reads for this variant; ClinVar itself did not change its classification.

Module explainers by health area

Peer-reviewed module explainers grouped by the 6 health areas Varia reports in V1. Each page describes the biology, what Varia analyzes, and key sources.

See the variant catalog

Heart & Lipids

Cardiovascular and lipid clearance

Brain & Cognition

Metabolism & Longevity

Medication Response

Cancer Risk

Cancer risk

Autoimmune

Autoimmune risk

On Varia's active watchlist, monitored against the peer-reviewed literature for catalog inclusion:

Accepted Peer-Reviewed Genes

Gene-level summary of the validated set Varia scans for. Generated from the same catalog index as the scanner.

Reading the tiers

Each variant carries a significance tier for its strongest published association. On a gene row, Highest tier shows the strongest tier among that gene's variants.

Elevated. The catalog's most significant increased-risk associations, always paired with physician-conversation framing.
High. Well-supported increased-risk associations.
Pharmacogenomic. Informs how the body responds to specific medications rather than disease risk.
Moderate. Supported associations with a smaller shift in risk.
Protective. Associated with reduced risk.
Neutral. Documented, with no meaningful shift in risk either way.
Unresolved. Published evidence is conflicting or insufficient to grade.

Accepted List

Grouped by domain. Each entry links to its supporting citations in the Citation Library.

Pipeline / Watchlist

Well-known variants Varia does not report yet. Descriptive only; no genotype calls or interpretations.