Coverage Areas
Varia curates 14 focused areas. Each page names the variants in that area and the papers behind them. The scanner reports only what this catalog covers.
Start with the area that matches the question you brought. Every finding still has to earn its place in the catalog. See the Variant Catalog for the current list, and Methodology for how a variant gets in.
Heart and lipids
Brain and cognition
APOE and Alzheimer's risk
The common genetic risk factor most strongly tied to late-onset Alzheimer's disease.
Alzheimer's clearance loci
Independent systems for clearing beta-amyloid, beyond APOE itself.
Chromosome 19 risk corridor
Genes around APOE that can amplify or moderate the risk APOE already confers.
APOC1 H2 haplotype
A promoter variant that can amplify APOE4 pathology through two mechanisms.
Neuro-cognitive and pharmacogenomics
Brain chemistry and drug metabolism that share more genetic architecture than they first appear to.
Metabolism and longevity
Metabolic and type 2 diabetes
Validated variants for type 2 diabetes risk, insulin regulation, and carbohydrate processing.
Longevity and telomere
Variants found more often in people who live to 100, and telomere biology behind that pattern.
Methylation and detoxification
The methylation cycle: gene expression, neurotransmitter synthesis, homocysteine, and DNA repair.
Inflammation and oxidative stress
Low-grade inflammation as a shared thread across heart, brain, metabolism, and aging.
