{
  "schema_version": 1,
  "generated_from": "scripts/catalog/evidence-records",
  "charter_section": 7,
  "summary": {
    "snps_covered": 64,
    "genotypes_with_number": 19,
    "genotypes_framing_only": 167,
    "distinct_pmids_cited": 10,
    "records_unverified": 15,
    "absent_chain_field_count": 6
  },
  "distinct_pmids": [
    "12387655",
    "16415884",
    "18650507",
    "18765803",
    "19734902",
    "19734903",
    "20032323",
    "23150908",
    "7877648",
    "8916933"
  ],
  "snps": [
    {
      "rsid": "rs10455872",
      "gene": "LPA",
      "verified": true,
      "effect_allele": "G",
      "direction": "risk",
      "direction_source": "pmid:20032323",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "reference homozygote (non-carrier)"
        },
        {
          "mode": "number",
          "rsid": "rs10455872",
          "gene": "LPA",
          "genotype": "A,G",
          "value": 1.7,
          "metric": "OR",
          "trait": "coronary artery disease",
          "zygosity_basis": "per_allele",
          "pmid": "20032323",
          "verbatim_quote": "We identified a common variant (rs10455872) at the LPA locus with an odds ratio for coronary disease of 1.70 (95% confidence interval [CI], 1.49 to 1.95) and another independent variant (rs3798220) with an odds ratio of 1.92 (95% CI, 1.48 to 2.49).",
          "effect_allele": "G",
          "direction": "risk",
          "direction_source": "pmid:20032323"
        },
        {
          "mode": "number",
          "rsid": "rs10455872",
          "gene": "LPA",
          "genotype": "G,G",
          "value": 1.7,
          "metric": "OR",
          "trait": "coronary artery disease",
          "zygosity_basis": "per_allele",
          "pmid": "20032323",
          "verbatim_quote": "We identified a common variant (rs10455872) at the LPA locus with an odds ratio for coronary disease of 1.70 (95% confidence interval [CI], 1.49 to 1.95) and another independent variant (rs3798220) with an odds ratio of 1.92 (95% CI, 1.48 to 2.49).",
          "effect_allele": "G",
          "direction": "risk",
          "direction_source": "pmid:20032323"
        }
      ]
    },
    {
      "rsid": "rs1057910",
      "gene": "CYP2C9",
      "verified": true,
      "effect_allele": "C",
      "direction": "none",
      "direction_source": "cpic:CYP2C9*3",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "A,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs10757278",
      "gene": "CDKN2B-AS1",
      "verified": true,
      "effect_allele": "G",
      "direction": "risk",
      "direction_source": "gwas_catalog:rs10757278-G",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "reference homozygote (non-carrier)"
        },
        {
          "genotype": "A,G",
          "mode": "framing_only",
          "reason": "carrier without displayable cited figure for this zygosity"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "homozygous OR 1.64 in PMID 17478679 lacks a reported confidence interval; prose-only display"
        }
      ]
    },
    {
      "rsid": "rs10795668",
      "gene": "10p14",
      "verified": false,
      "effect_allele": "A",
      "direction": "none",
      "direction_source": "gwas_catalog:rs10795668-G",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "A,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs10936599",
      "gene": "TERC",
      "verified": true,
      "effect_allele": "C",
      "direction": "none",
      "direction_source": "gwas_catalog:rs10936599-T",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs11136000",
      "gene": "CLU / Clusterin",
      "verified": true,
      "effect_allele": "T",
      "direction": "protective",
      "direction_source": "gwas_catalog:rs11136000-?",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "reference homozygote (non-carrier of protective T allele)"
        },
        {
          "mode": "number",
          "rsid": "rs11136000",
          "gene": "CLU / Clusterin",
          "genotype": "C,T",
          "value": 0.86,
          "metric": "OR",
          "trait": "Alzheimer's disease",
          "zygosity_basis": "per_allele",
          "pmid": "19734903",
          "verbatim_quote": "Two loci gave replicated evidence of association: one within CLU (also called APOJ), encoding clusterin or apolipoprotein J, on chromosome 8 (rs11136000, OR = 0.86, 95% CI 0.81-0.90, P = 7.5 x 10(-9) for combined data) and the other within CR1, encoding the complement component (3b/4b) receptor 1, on chromosome 1 (rs6656401, OR = 1.21, 95% CI 1.14-1.29, P = 3.7 x 10(-9) for combined data).",
          "effect_allele": "T",
          "direction": "protective",
          "direction_source": "gwas_catalog:rs11136000-?"
        },
        {
          "mode": "number",
          "rsid": "rs11136000",
          "gene": "CLU / Clusterin",
          "genotype": "T,T",
          "value": 0.86,
          "metric": "OR",
          "trait": "Alzheimer's disease",
          "zygosity_basis": "per_allele",
          "pmid": "19734903",
          "verbatim_quote": "Two loci gave replicated evidence of association: one within CLU (also called APOJ), encoding clusterin or apolipoprotein J, on chromosome 8 (rs11136000, OR = 0.86, 95% CI 0.81-0.90, P = 7.5 x 10(-9) for combined data) and the other within CR1, encoding the complement component (3b/4b) receptor 1, on chromosome 1 (rs6656401, OR = 1.21, 95% CI 1.14-1.29, P = 3.7 x 10(-9) for combined data).",
          "effect_allele": "T",
          "direction": "protective",
          "direction_source": "gwas_catalog:rs11136000-?"
        }
      ]
    },
    {
      "rsid": "rs1143679",
      "gene": "ITGAM",
      "verified": false,
      "effect_allele": "A",
      "direction": "none",
      "direction_source": "pmid:19286673",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "A,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs11591147",
      "gene": "PCSK9",
      "verified": true,
      "effect_allele": "T",
      "direction": "none",
      "direction_source": "editorial_determination:rs11591147-no-effect-estimate",
      "genotypes": [
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs12248560",
      "gene": "CYP2C19",
      "verified": true,
      "effect_allele": "C",
      "direction": "none",
      "direction_source": "cpic:CYP2C19*17",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "C,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs1333049",
      "gene": "CDKN2B-AS1",
      "verified": true,
      "effect_allele": "C",
      "direction": "risk",
      "direction_source": "gwas_catalog:rs1333049-C",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "cited figure withdrawn: 1.64 belongs to rs10757278, not this variant (see withheld_figures)"
        },
        {
          "genotype": "G,C",
          "mode": "framing_only",
          "reason": "carrier without displayable cited figure for this zygosity"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "reference homozygote (non-carrier)"
        }
      ]
    },
    {
      "rsid": "rs13387042",
      "gene": "2q35",
      "verified": false,
      "effect_allele": "A",
      "direction": "none",
      "direction_source": "pmid:19567422",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "A,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs1360780",
      "gene": "FKBP5",
      "verified": true,
      "effect_allele": "C",
      "direction": "none",
      "direction_source": "editorial_determination:rs1360780-no-effect-estimate",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "C,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs174537",
      "gene": "FADS1",
      "verified": true,
      "effect_allele": "G",
      "direction": "none",
      "direction_source": "editorial_determination:rs174537-no-displayable-estimate",
      "genotypes": [
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs1799945",
      "gene": "HFE",
      "verified": true,
      "effect_allele": "G",
      "direction": "none",
      "direction_source": "clinvar:HFE-H63D",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "C,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs1799963",
      "gene": "F2 / Prothrombin G20210A",
      "verified": true,
      "effect_allele": "A",
      "direction": "risk",
      "direction_source": "clinvar:Prothrombin-G20210A",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "PMID 8916933 reports per-A-allele OR 2.8 only; no homozygous point estimate with CI"
        },
        {
          "mode": "number",
          "rsid": "rs1799963",
          "gene": "F2 / Prothrombin G20210A",
          "genotype": "G,A",
          "value": 2.8,
          "metric": "OR",
          "trait": "venous thromboembolism",
          "zygosity_basis": "per_allele",
          "pmid": "8916933",
          "verbatim_quote": "In a population-based case-control study, the 20210 A allele was identified as a common allele (allele frequency, 1.2%; 95% confidence interval, 0.5% to 1.8%), which increased the risk of venous thrombosis almost threefold {odds ratio, 2.8; 95% confidence interval, 1.4 to 5.6}.",
          "effect_allele": "A",
          "direction": "risk",
          "direction_source": "clinvar:Prothrombin-G20210A"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "reference homozygote (non-carrier)"
        }
      ]
    },
    {
      "rsid": "rs1799983",
      "gene": "NOS3 / eNOS",
      "verified": true,
      "effect_allele": "T",
      "direction": "risk",
      "direction_source": "gwas_catalog:rs1799983-T",
      "genotypes": [
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "reference homozygote (non-carrier)"
        },
        {
          "genotype": "G,T",
          "mode": "framing_only",
          "reason": "carrier without displayable cited figure for this zygosity"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "dual_source adjudication rule 3: PMID 10510054 hom OR 4.2 (single angiographic cohort) not replicated at GWAS per-allele OR ~1.05"
        }
      ]
    },
    {
      "rsid": "rs1800497",
      "gene": "ANKK1/DRD2",
      "verified": true,
      "effect_allele": "G",
      "direction": "none",
      "direction_source": "pmid:1969501",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs1800562",
      "gene": "HFE",
      "verified": true,
      "effect_allele": "A",
      "direction": "risk",
      "direction_source": "clinvar:HFE-C282Y",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "carrier without displayable cited figure for this zygosity"
        },
        {
          "genotype": "G,A",
          "mode": "framing_only",
          "reason": "carrier without displayable cited figure for this zygosity"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "reference homozygote (non-carrier)"
        }
      ]
    },
    {
      "rsid": "rs1800795",
      "gene": "IL6",
      "verified": true,
      "effect_allele": "C",
      "direction": "none",
      "direction_source": "editorial_determination:rs1800795-no-effect-estimate",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs1801131",
      "gene": "MTHFR",
      "verified": true,
      "effect_allele": "G",
      "direction": "none",
      "direction_source": "editorial_determination:rs1801131-no-displayable-estimate",
      "genotypes": [
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs1801133",
      "gene": "MTHFR",
      "verified": true,
      "effect_allele": "A",
      "direction": "risk",
      "direction_source": "pmid:12387655",
      "genotypes": [
        {
          "mode": "number",
          "rsid": "rs1801133",
          "gene": "MTHFR",
          "genotype": "A,A",
          "value": 1.16,
          "metric": "OR",
          "trait": "coronary heart disease",
          "zygosity_basis": "hom_comparison",
          "pmid": "12387655",
          "verbatim_quote": "Data synthesis Individuals with the MTHFR 677 TT genotype had a 16% (OR, 1.16; 95% confidence interval [CI], 1.05-1.28) higher odds of CHD compared with individuals with the CC genotype.",
          "effect_allele": "A",
          "direction": "risk",
          "direction_source": "pmid:12387655"
        },
        {
          "genotype": "G,A",
          "mode": "framing_only",
          "reason": "carrier without displayable cited figure for this zygosity"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "reference homozygote (non-carrier)"
        }
      ]
    },
    {
      "rsid": "rs1859962",
      "gene": "17q24.3",
      "verified": false,
      "effect_allele": "G",
      "direction": "none",
      "direction_source": "gwas_catalog:rs1859962-G",
      "genotypes": [
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs2070744",
      "gene": "NOS3 / eNOS",
      "verified": true,
      "effect_allele": "T",
      "direction": "none",
      "direction_source": "editorial_determination:rs2070744-no-effect-estimate",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs2075650",
      "gene": "TOMM40",
      "verified": true,
      "effect_allele": "A",
      "direction": "none",
      "direction_source": "editorial_determination:rs2075650-no-displayable-estimate",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs2253310",
      "gene": "FOXO3",
      "verified": true,
      "effect_allele": "G",
      "direction": "none",
      "direction_source": "pmid:18765803",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "reference; no G longevity allele"
        },
        {
          "genotype": "C,G",
          "mode": "framing_only",
          "reason": "one G longevity allele; qualitative framing"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "homozygous G longevity tag; qualitative framing"
        }
      ]
    },
    {
      "rsid": "rs2476601",
      "gene": "PTPN22",
      "verified": false,
      "effect_allele": "A",
      "direction": "none",
      "direction_source": "pmid:15208781",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "A,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs2494732",
      "gene": "AKT1",
      "verified": true,
      "effect_allele": "C",
      "direction": "none",
      "direction_source": "editorial_determination:rs2494732-no-effect-estimate",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "C,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs2736100",
      "gene": "TERT",
      "verified": true,
      "effect_allele": "C",
      "direction": "none",
      "direction_source": "gwas_catalog:rs2736100-C",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "C,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs2802292",
      "gene": "FOXO3",
      "verified": true,
      "effect_allele": "G",
      "direction": "protective",
      "direction_source": "pmid:18765803",
      "genotypes": [
        {
          "mode": "number",
          "rsid": "rs2802292",
          "gene": "FOXO3",
          "genotype": "G,G",
          "value": 2.75,
          "metric": "OR",
          "trait": "human longevity",
          "zygosity_basis": "hom_comparison",
          "pmid": "18765803",
          "verbatim_quote": "The OR for homozygous minor vs. homozygous major alleles between the cases and controls was 2.75 (P = 0.00009; adjusted P = 0.00135).",
          "effect_allele": "G",
          "direction": "protective",
          "direction_source": "pmid:18765803"
        },
        {
          "genotype": "T,G",
          "mode": "framing_only",
          "reason": "carrier without displayable cited figure for this zygosity"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "reference homozygote (non-carrier)"
        }
      ]
    },
    {
      "rsid": "rs2981582",
      "gene": "FGFR2",
      "verified": false,
      "effect_allele": "A",
      "direction": "none",
      "direction_source": "gwas_catalog:rs2981582-A",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "A,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs3764650",
      "gene": "ABCA7",
      "verified": true,
      "effect_allele": "G",
      "direction": "none",
      "direction_source": "gwas_catalog:rs3764650-?",
      "genotypes": [
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs3798220",
      "gene": "LPA",
      "verified": true,
      "effect_allele": "C",
      "direction": "risk",
      "direction_source": "pmid:20032323",
      "genotypes": [
        {
          "mode": "number",
          "rsid": "rs3798220",
          "gene": "LPA",
          "genotype": "C,C",
          "value": 1.92,
          "metric": "OR",
          "trait": "coronary artery disease",
          "zygosity_basis": "per_allele",
          "pmid": "20032323",
          "verbatim_quote": "We identified a common variant (rs10455872) at the LPA locus with an odds ratio for coronary disease of 1.70 (95% confidence interval [CI], 1.49 to 1.95) and another independent variant (rs3798220) with an odds ratio of 1.92 (95% CI, 1.48 to 2.49).",
          "effect_allele": "C",
          "direction": "risk",
          "direction_source": "pmid:20032323"
        },
        {
          "mode": "number",
          "rsid": "rs3798220",
          "gene": "LPA",
          "genotype": "C,T",
          "value": "(absent)",
          "metric": "(absent)",
          "trait": "(absent)",
          "zygosity_basis": "(absent)",
          "pmid": "(absent)",
          "verbatim_quote": "(absent)",
          "effect_allele": "C",
          "direction": "risk",
          "direction_source": "pmid:20032323"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "reference homozygote (non-carrier)"
        }
      ]
    },
    {
      "rsid": "rs3803662",
      "gene": "TOX3",
      "verified": false,
      "effect_allele": "A",
      "direction": "none",
      "direction_source": "gwas_catalog:rs3803662-T",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs3814113",
      "gene": "BNC2",
      "verified": false,
      "effect_allele": "C",
      "direction": "none",
      "direction_source": "pmid:19648919",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "C,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs3851179",
      "gene": "PICALM",
      "verified": true,
      "effect_allele": "T",
      "direction": "protective",
      "direction_source": "gwas_catalog:rs3851179-T",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "reference homozygote (non-carrier of protective T allele)"
        },
        {
          "mode": "number",
          "rsid": "rs3851179",
          "gene": "PICALM",
          "genotype": "C,T",
          "value": 0.86,
          "metric": "OR",
          "trait": "Alzheimer's disease",
          "zygosity_basis": "per_allele",
          "pmid": "19734902",
          "verbatim_quote": "These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86).",
          "effect_allele": "T",
          "direction": "protective",
          "direction_source": "gwas_catalog:rs3851179-T"
        },
        {
          "mode": "number",
          "rsid": "rs3851179",
          "gene": "PICALM",
          "genotype": "T,T",
          "value": 0.86,
          "metric": "OR",
          "trait": "Alzheimer's disease",
          "zygosity_basis": "per_allele",
          "pmid": "19734902",
          "verbatim_quote": "These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86).",
          "effect_allele": "T",
          "direction": "protective",
          "direction_source": "gwas_catalog:rs3851179-T"
        }
      ]
    },
    {
      "rsid": "rs4149056",
      "gene": "SLCO1B1",
      "verified": true,
      "effect_allele": "C",
      "direction": "risk",
      "direction_source": "cpic:SLCO1B1-statin-myopathy",
      "genotypes": [
        {
          "mode": "number",
          "rsid": "rs4149056",
          "gene": "SLCO1B1",
          "genotype": "C,C",
          "value": 4.5,
          "metric": "OR",
          "trait": "statin-induced myopathy",
          "zygosity_basis": "per_allele",
          "pmid": "18650507",
          "verbatim_quote": "The odds ratio for myopathy was 4.5 (95% confidence interval [CI], 2.6 to 7.7) per copy of the C allele, and 16.9 (95% CI, 4.7 to 61.1) in CC as compared with TT homozygotes.",
          "effect_allele": "C",
          "direction": "risk",
          "direction_source": "cpic:SLCO1B1-statin-myopathy"
        },
        {
          "mode": "number",
          "rsid": "rs4149056",
          "gene": "SLCO1B1",
          "genotype": "T,C",
          "value": 4.5,
          "metric": "OR",
          "trait": "statin-induced myopathy",
          "zygosity_basis": "per_allele",
          "pmid": "18650507",
          "verbatim_quote": "The odds ratio for myopathy was 4.5 (95% confidence interval [CI], 2.6 to 7.7) per copy of the C allele, and 16.9 (95% CI, 4.7 to 61.1) in CC as compared with TT homozygotes.",
          "effect_allele": "C",
          "direction": "risk",
          "direction_source": "cpic:SLCO1B1-statin-myopathy"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "reference homozygote (non-carrier)"
        }
      ]
    },
    {
      "rsid": "rs4244285",
      "gene": "CYP2C19",
      "verified": true,
      "effect_allele": "A",
      "direction": "none",
      "direction_source": "cpic:CYP2C19*2",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs429358",
      "gene": "APOE",
      "verified": true,
      "effect_allele": "(absent)",
      "direction": "none",
      "direction_source": "pmid:9343467",
      "genotypes": []
    },
    {
      "rsid": "rs4420638",
      "gene": "APOC1",
      "verified": true,
      "effect_allele": "G",
      "direction": "none",
      "direction_source": "editorial_determination:rs4420638-no-displayable-estimate",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "A,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs4430796",
      "gene": "HNF1B",
      "verified": false,
      "effect_allele": "G",
      "direction": "none",
      "direction_source": "pmid:18701471",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs4779584",
      "gene": "GREM1",
      "verified": false,
      "effect_allele": "T",
      "direction": "none",
      "direction_source": "pmid:21655089",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs4946936",
      "gene": "FOXO3",
      "verified": true,
      "effect_allele": "T",
      "direction": "none",
      "direction_source": "editorial_determination:rs4946936-no-displayable-estimate",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "C,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs4988235",
      "gene": "LCT / MCM6",
      "verified": true,
      "effect_allele": "A",
      "direction": "none",
      "direction_source": "pmid:11788828",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "homozygous persistence; qualitative trait framing"
        },
        {
          "genotype": "G,A",
          "mode": "framing_only",
          "reason": "heterozygous persistence; qualitative trait framing"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "non-persistence reference"
        }
      ]
    },
    {
      "rsid": "rs505922",
      "gene": "ABO",
      "verified": false,
      "effect_allele": "C",
      "direction": "none",
      "direction_source": "pmid:19648918",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "C,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs564481",
      "gene": "KL",
      "verified": true,
      "effect_allele": "C",
      "direction": "none",
      "direction_source": "editorial_determination:rs564481-no-displayable-estimate",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs5751876",
      "gene": "ADORA2A",
      "verified": true,
      "effect_allele": "T",
      "direction": "none",
      "direction_source": "editorial_determination:rs5751876-no-effect-estimate",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs6025",
      "gene": "F5 / Factor V Leiden",
      "verified": true,
      "effect_allele": "T",
      "direction": "risk",
      "direction_source": "clinvar:RCV000000123",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "reference homozygote (non-carrier)"
        },
        {
          "mode": "number",
          "rsid": "rs6025",
          "gene": "F5 / Factor V Leiden",
          "genotype": "C,T",
          "value": 3.5,
          "metric": "RR",
          "trait": "venous thrombosis",
          "zygosity_basis": "het",
          "pmid": "7877648",
          "verbatim_quote": "This increased risk was seen with primary venous thrombosis (relative risk, 3.5; 95 percent confidence interval, 1.5 to 8.4; P = 0.004) but not with secondary venous thrombosis (relative risk, 1.7; 95 percent confidence interval, 0.6 to 5.3; P = 0.3), and it was most apparent among older men.",
          "effect_allele": "T",
          "direction": "risk",
          "direction_source": "clinvar:RCV000000123"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "carrier without displayable cited figure for this zygosity"
        }
      ]
    },
    {
      "rsid": "rs6265",
      "gene": "BDNF",
      "verified": true,
      "effect_allele": "T",
      "direction": "none",
      "direction_source": "editorial_determination:rs6265-no-effect-estimate",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "C,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs641120",
      "gene": "SORL1",
      "verified": true,
      "effect_allele": "(absent)",
      "direction": "none",
      "direction_source": "editorial_determination:rs641120-no-single-direction",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs6511720",
      "gene": "LDLR",
      "verified": true,
      "effect_allele": "T",
      "direction": "none",
      "direction_source": "gwas_catalog:rs6511720-T",
      "genotypes": [
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs6656401",
      "gene": "CR1",
      "verified": true,
      "effect_allele": "A",
      "direction": "risk",
      "direction_source": "gwas_catalog:rs6656401-A",
      "genotypes": [
        {
          "mode": "number",
          "rsid": "rs6656401",
          "gene": "CR1",
          "genotype": "A,A",
          "value": 1.21,
          "metric": "OR",
          "trait": "Alzheimer's disease",
          "zygosity_basis": "het",
          "pmid": "19734903",
          "verbatim_quote": "Two loci gave replicated evidence of association: one within CLU (also called APOJ), encoding clusterin or apolipoprotein J, on chromosome 8 (rs11136000, OR = 0.86, 95% CI 0.81-0.90, P = 7.5 x 10(-9) for combined data) and the other within CR1, encoding the complement component (3b/4b) receptor 1, on chromosome 1 (rs6656401, OR = 1.21, 95% CI 1.14-1.29, P = 3.7 x 10(-9) for combined data).",
          "effect_allele": "A",
          "direction": "risk",
          "direction_source": "gwas_catalog:rs6656401-A"
        },
        {
          "mode": "number",
          "rsid": "rs6656401",
          "gene": "CR1",
          "genotype": "A,G",
          "value": 1.21,
          "metric": "OR",
          "trait": "Alzheimer's disease",
          "zygosity_basis": "het",
          "pmid": "19734903",
          "verbatim_quote": "Two loci gave replicated evidence of association: one within CLU (also called APOJ), encoding clusterin or apolipoprotein J, on chromosome 8 (rs11136000, OR = 0.86, 95% CI 0.81-0.90, P = 7.5 x 10(-9) for combined data) and the other within CR1, encoding the complement component (3b/4b) receptor 1, on chromosome 1 (rs6656401, OR = 1.21, 95% CI 1.14-1.29, P = 3.7 x 10(-9) for combined data).",
          "effect_allele": "A",
          "direction": "risk",
          "direction_source": "gwas_catalog:rs6656401-A"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "reference homozygote (non-carrier)"
        }
      ]
    },
    {
      "rsid": "rs693",
      "gene": "APOB",
      "verified": true,
      "effect_allele": "A",
      "direction": "none",
      "direction_source": "gwas_catalog:rs693-A",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs6983267",
      "gene": "8q24",
      "verified": false,
      "effect_allele": "G",
      "direction": "none",
      "direction_source": "pmid:17618284",
      "genotypes": [
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs7412",
      "gene": "APOE",
      "verified": true,
      "effect_allele": "(absent)",
      "direction": "none",
      "direction_source": "pmid:9343467",
      "genotypes": []
    },
    {
      "rsid": "rs7561528",
      "gene": "BIN1",
      "verified": true,
      "effect_allele": "(absent)",
      "direction": "none",
      "direction_source": "gwas_catalog:rs7561528-A",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "A,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs7574865",
      "gene": "STAT4",
      "verified": false,
      "effect_allele": "T",
      "direction": "none",
      "direction_source": "pmid:17804842",
      "genotypes": [
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs75932628",
      "gene": "TREM2",
      "verified": true,
      "effect_allele": "T",
      "direction": "risk",
      "direction_source": "pmid:23150908",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "reference homozygote (non-carrier)"
        },
        {
          "mode": "number",
          "rsid": "rs75932628",
          "gene": "TREM2",
          "genotype": "C,T",
          "value": 2.92,
          "metric": "OR",
          "trait": "Alzheimer's disease",
          "zygosity_basis": "per_allele",
          "pmid": "23150908",
          "verbatim_quote": "Results A rare missense mutation (rs75932628-T) in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2), which was predicted to result in an R47H substitution, was found to confer a significant risk of Alzheimer's disease in Iceland (odds ratio, 2.92; 95% confidence interval [CI], 2.09 to 4.09; P=3.42×10(-10)).",
          "effect_allele": "T",
          "direction": "risk",
          "direction_source": "pmid:23150908"
        },
        {
          "mode": "number",
          "rsid": "rs75932628",
          "gene": "TREM2",
          "genotype": "T,T",
          "value": 2.92,
          "metric": "OR",
          "trait": "Alzheimer's disease",
          "zygosity_basis": "per_allele",
          "pmid": "23150908",
          "verbatim_quote": "Results A rare missense mutation (rs75932628-T) in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2), which was predicted to result in an R47H substitution, was found to confer a significant risk of Alzheimer's disease in Iceland (odds ratio, 2.92; 95% confidence interval [CI], 2.09 to 4.09; P=3.42×10(-10)).",
          "effect_allele": "T",
          "direction": "risk",
          "direction_source": "pmid:23150908"
        }
      ]
    },
    {
      "rsid": "rs762551",
      "gene": "CYP1A2",
      "verified": true,
      "effect_allele": "C",
      "direction": "none",
      "direction_source": "editorial_determination:rs762551-no-effect-estimate",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "A,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs7903146",
      "gene": "TCF7L2",
      "verified": true,
      "effect_allele": "T",
      "direction": "risk",
      "direction_source": "gwas_catalog:rs7903146-T",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "reference homozygote (non-carrier)"
        },
        {
          "mode": "number",
          "rsid": "rs7903146",
          "gene": "TCF7L2",
          "genotype": "C,T",
          "value": 1.45,
          "metric": "RR",
          "trait": "type 2 diabetes",
          "zygosity_basis": "het",
          "pmid": "16415884",
          "verbatim_quote": "Compared with non-carriers, heterozygous and homozygous carriers of the at-risk alleles (38% and 7% of the population, respectively) have relative risks of 1.45 and 2.41.",
          "effect_allele": "T",
          "direction": "risk",
          "direction_source": "gwas_catalog:rs7903146-T"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "carrier without displayable cited figure for this zygosity"
        }
      ]
    },
    {
      "rsid": "rs910873",
      "gene": "ASIP",
      "verified": false,
      "effect_allele": "G",
      "direction": "none",
      "direction_source": "pmid:18488026",
      "genotypes": [
        {
          "genotype": "A,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,A",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs9527025",
      "gene": "KL",
      "verified": true,
      "effect_allele": "C",
      "direction": "disadvantage",
      "direction_source": "pmid:11792841",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "homozygous KL-VS; overdominance; cited figure not displayed"
        },
        {
          "genotype": "C,G",
          "mode": "framing_only",
          "reason": "heterozygote advantage genotype; qualitative display"
        },
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "reference homozygote (non-carrier of KL-VS C allele)"
        }
      ]
    },
    {
      "rsid": "rs9536314",
      "gene": "KL",
      "verified": true,
      "effect_allele": "G",
      "direction": "disadvantage",
      "direction_source": "pmid:11792841",
      "genotypes": [
        {
          "genotype": "G,G",
          "mode": "framing_only",
          "reason": "homozygous KL-VS; overdominance; cited figure not displayed"
        },
        {
          "genotype": "T,G",
          "mode": "framing_only",
          "reason": "heterozygote advantage genotype; qualitative display"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "reference homozygote (non-carrier of KL-VS G allele)"
        }
      ]
    },
    {
      "rsid": "rs9543325",
      "gene": "13q22.1",
      "verified": false,
      "effect_allele": "C",
      "direction": "none",
      "direction_source": "pmid:20101243",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "C,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    },
    {
      "rsid": "rs9923231",
      "gene": "VKORC1",
      "verified": true,
      "effect_allele": "T",
      "direction": "none",
      "direction_source": "cpic:VKORC1-warfarin",
      "genotypes": [
        {
          "genotype": "C,C",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "C,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        },
        {
          "genotype": "T,T",
          "mode": "framing_only",
          "reason": "authoritatively pinned framing-only"
        }
      ]
    }
  ]
}