{
  "schema_version": "v1.1",
  "summary": {
    "run_date": "2026-05-28",
    "catalog_scope": "all",
    "graded_count": 470,
    "skipped_existing_override_count": 0,
    "override_events_appended": 0,
    "trace_count": 470
  },
  "entries": [
    {
      "catalog_entry_id": "apoe_alzheimers|rs429358|insights|rs429358%3AT%2CT%20%7C%20rs7412%3AT%2CT",
      "rsid": "rs429358",
      "gene": "APOE (codon 112)",
      "module_id": "apoe_alzheimers",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Well-replicated",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Routine discussion",
      "feature_summary": {
        "citation_count": 1338,
        "tier1_citation_count": 3,
        "unique_cohort_count": 13,
        "effect_direction_agreement_pct": 89,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=APOE (codon 112), domain=apoe_alzheimers, citations=1338, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "apoe_alzheimers|rs429358|insights|rs429358%3AT%2CT%20%7C%20rs7412%3AC%2CT",
      "rsid": "rs429358",
      "gene": "APOE (codon 112)",
      "module_id": "apoe_alzheimers",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Well-replicated",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Routine discussion",
      "feature_summary": {
        "citation_count": 1338,
        "tier1_citation_count": 3,
        "unique_cohort_count": 13,
        "effect_direction_agreement_pct": 89,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=APOE (codon 112), domain=apoe_alzheimers, citations=1338, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "apoe_alzheimers|rs429358|insights|rs429358%3AT%2CT%20%7C%20rs7412%3AC%2CC",
      "rsid": "rs429358",
      "gene": "APOE (codon 112)",
      "module_id": "apoe_alzheimers",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Well-replicated",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Routine discussion",
      "feature_summary": {
        "citation_count": 1338,
        "tier1_citation_count": 3,
        "unique_cohort_count": 13,
        "effect_direction_agreement_pct": 89,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=APOE (codon 112), domain=apoe_alzheimers, citations=1338, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "apoe_alzheimers|rs429358|insights|rs429358%3AC%2CT%20%7C%20rs7412%3AC%2CC",
      "rsid": "rs429358",
      "gene": "APOE (codon 112)",
      "module_id": "apoe_alzheimers",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Well-replicated",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Routine discussion",
      "feature_summary": {
        "citation_count": 1338,
        "tier1_citation_count": 3,
        "unique_cohort_count": 13,
        "effect_direction_agreement_pct": 89,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=APOE (codon 112), domain=apoe_alzheimers, citations=1338, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "apoe_alzheimers|rs429358|insights|rs429358%3AC%2CC%20%7C%20rs7412%3AC%2CC",
      "rsid": "rs429358",
      "gene": "APOE (codon 112)",
      "module_id": "apoe_alzheimers",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Well-replicated",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Routine discussion",
      "feature_summary": {
        "citation_count": 1338,
        "tier1_citation_count": 3,
        "unique_cohort_count": 13,
        "effect_direction_agreement_pct": 89,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=APOE (codon 112), domain=apoe_alzheimers, citations=1338, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "apoe_alzheimers|rs429358|insights|rs429358%3AC%2CT%20%7C%20rs7412%3AC%2CT",
      "rsid": "rs429358",
      "gene": "APOE (codon 112)",
      "module_id": "apoe_alzheimers",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Well-replicated",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Routine discussion",
      "feature_summary": {
        "citation_count": 1338,
        "tier1_citation_count": 3,
        "unique_cohort_count": 13,
        "effect_direction_agreement_pct": 89,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=APOE (codon 112), domain=apoe_alzheimers, citations=1338, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "apoe_alzheimers|rs7412|genotypes|C%2CC",
      "rsid": "rs7412",
      "gene": "APOE (codon 158)",
      "module_id": "apoe_alzheimers",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 1041,
        "tier1_citation_count": 0,
        "unique_cohort_count": 41,
        "effect_direction_agreement_pct": 93,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=APOE (codon 158), domain=apoe_alzheimers, citations=1041, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "apoe_alzheimers|rs7412|genotypes|C%2CT",
      "rsid": "rs7412",
      "gene": "APOE (codon 158)",
      "module_id": "apoe_alzheimers",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 1041,
        "tier1_citation_count": 0,
        "unique_cohort_count": 41,
        "effect_direction_agreement_pct": 93,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=APOE (codon 158), domain=apoe_alzheimers, citations=1041, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "apoe_alzheimers|rs7412|genotypes|T%2CT",
      "rsid": "rs7412",
      "gene": "APOE (codon 158)",
      "module_id": "apoe_alzheimers",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 1041,
        "tier1_citation_count": 0,
        "unique_cohort_count": 41,
        "effect_direction_agreement_pct": 93,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=APOE (codon 158), domain=apoe_alzheimers, citations=1041, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "chr19_corridor|rs2075650|insights|G%2CG",
      "rsid": "rs2075650",
      "gene": "TOMM40",
      "module_id": "chr19_corridor",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 136,
        "tier1_citation_count": 1,
        "unique_cohort_count": 39,
        "effect_direction_agreement_pct": 73,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TOMM40, domain=chr19_corridor, citations=136, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "chr19_corridor|rs2075650|insights|A%2CG",
      "rsid": "rs2075650",
      "gene": "TOMM40",
      "module_id": "chr19_corridor",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 136,
        "tier1_citation_count": 1,
        "unique_cohort_count": 39,
        "effect_direction_agreement_pct": 73,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TOMM40, domain=chr19_corridor, citations=136, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "chr19_corridor|rs2075650|insights|A%2CA",
      "rsid": "rs2075650",
      "gene": "TOMM40",
      "module_id": "chr19_corridor",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 136,
        "tier1_citation_count": 1,
        "unique_cohort_count": 39,
        "effect_direction_agreement_pct": 73,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TOMM40, domain=chr19_corridor, citations=136, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "chr19_corridor|rs2075650|genotypes|G%2CG",
      "rsid": "rs2075650",
      "gene": "TOMM40",
      "module_id": "chr19_corridor",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 136,
        "tier1_citation_count": 1,
        "unique_cohort_count": 39,
        "effect_direction_agreement_pct": 73,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TOMM40, domain=chr19_corridor, citations=136, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "chr19_corridor|rs2075650|genotypes|G%2CA",
      "rsid": "rs2075650",
      "gene": "TOMM40",
      "module_id": "chr19_corridor",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 136,
        "tier1_citation_count": 1,
        "unique_cohort_count": 39,
        "effect_direction_agreement_pct": 73,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TOMM40, domain=chr19_corridor, citations=136, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "chr19_corridor|rs2075650|genotypes|A%2CA",
      "rsid": "rs2075650",
      "gene": "TOMM40",
      "module_id": "chr19_corridor",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 136,
        "tier1_citation_count": 1,
        "unique_cohort_count": 39,
        "effect_direction_agreement_pct": 73,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TOMM40, domain=chr19_corridor, citations=136, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs10455872|genotypes|A%2CA",
      "rsid": "rs10455872",
      "gene": "LPA",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 737,
        "tier1_citation_count": 0,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 96,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=LPA, domain=cardiovascular_lipid, citations=737, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs10455872|genotypes|A%2CG",
      "rsid": "rs10455872",
      "gene": "LPA",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 737,
        "tier1_citation_count": 0,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 96,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=LPA, domain=cardiovascular_lipid, citations=737, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs10455872|genotypes|G%2CG",
      "rsid": "rs10455872",
      "gene": "LPA",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 737,
        "tier1_citation_count": 0,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 96,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=LPA, domain=cardiovascular_lipid, citations=737, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs3798220|genotypes|C%2CC",
      "rsid": "rs3798220",
      "gene": "LPA",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 38,
        "tier1_citation_count": 0,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 88,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=LPA, domain=cardiovascular_lipid, citations=38, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs3798220|genotypes|C%2CT",
      "rsid": "rs3798220",
      "gene": "LPA",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 38,
        "tier1_citation_count": 0,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 88,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=LPA, domain=cardiovascular_lipid, citations=38, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs3798220|genotypes|T%2CT",
      "rsid": "rs3798220",
      "gene": "LPA",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 38,
        "tier1_citation_count": 0,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 88,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=LPA, domain=cardiovascular_lipid, citations=38, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs11591147|genotypes|G%2CG",
      "rsid": "rs11591147",
      "gene": "PCSK9",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Pathogenic"
      ],
      "strength": null,
      "conversation_context": "Authority-graded; condition-associated",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": null,
        "tier1_citation_count": null,
        "unique_cohort_count": null,
        "effect_direction_agreement_pct": null,
        "total_cohort_n": null
      },
      "class_assignment_basis": "Pathogenic per Pass 0 router and class grader consensus: gene=PCSK9, domain=cardiovascular_lipid, citations=n/a, cohort_n=n/a.",
      "override_flag": true,
      "override_trigger_codes": [
        "authority_contradicts_catalog_class"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs11591147|genotypes|G%2CT",
      "rsid": "rs11591147",
      "gene": "PCSK9",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Pathogenic"
      ],
      "strength": null,
      "conversation_context": "Authority-graded; condition-associated",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": null,
        "tier1_citation_count": null,
        "unique_cohort_count": null,
        "effect_direction_agreement_pct": null,
        "total_cohort_n": null
      },
      "class_assignment_basis": "Pathogenic per Pass 0 router and class grader consensus: gene=PCSK9, domain=cardiovascular_lipid, citations=n/a, cohort_n=n/a.",
      "override_flag": true,
      "override_trigger_codes": [
        "authority_contradicts_catalog_class"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs11591147|genotypes|T%2CT",
      "rsid": "rs11591147",
      "gene": "PCSK9",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Pathogenic"
      ],
      "strength": null,
      "conversation_context": "Authority-graded; condition-associated",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": null,
        "tier1_citation_count": null,
        "unique_cohort_count": null,
        "effect_direction_agreement_pct": null,
        "total_cohort_n": null
      },
      "class_assignment_basis": "Pathogenic per Pass 0 router and class grader consensus: gene=PCSK9, domain=cardiovascular_lipid, citations=n/a, cohort_n=n/a.",
      "override_flag": true,
      "override_trigger_codes": [
        "authority_contradicts_catalog_class"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs6511720|genotypes|T%2CT",
      "rsid": "rs6511720",
      "gene": "LDLR",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Pathogenic"
      ],
      "strength": null,
      "conversation_context": "Authority-graded; condition-associated",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": null,
        "tier1_citation_count": null,
        "unique_cohort_count": null,
        "effect_direction_agreement_pct": null,
        "total_cohort_n": null
      },
      "class_assignment_basis": "Pathogenic per Pass 0 router and class grader consensus: gene=LDLR, domain=cardiovascular_lipid, citations=n/a, cohort_n=n/a.",
      "override_flag": true,
      "override_trigger_codes": [
        "authority_contradicts_catalog_class"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs6511720|genotypes|T%2CG",
      "rsid": "rs6511720",
      "gene": "LDLR",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Pathogenic"
      ],
      "strength": null,
      "conversation_context": "Authority-graded; condition-associated",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": null,
        "tier1_citation_count": null,
        "unique_cohort_count": null,
        "effect_direction_agreement_pct": null,
        "total_cohort_n": null
      },
      "class_assignment_basis": "Pathogenic per Pass 0 router and class grader consensus: gene=LDLR, domain=cardiovascular_lipid, citations=n/a, cohort_n=n/a.",
      "override_flag": true,
      "override_trigger_codes": [
        "authority_contradicts_catalog_class"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs6511720|genotypes|G%2CG",
      "rsid": "rs6511720",
      "gene": "LDLR",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Pathogenic"
      ],
      "strength": null,
      "conversation_context": "Authority-graded; condition-associated",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": null,
        "tier1_citation_count": null,
        "unique_cohort_count": null,
        "effect_direction_agreement_pct": null,
        "total_cohort_n": null
      },
      "class_assignment_basis": "Pathogenic per Pass 0 router and class grader consensus: gene=LDLR, domain=cardiovascular_lipid, citations=n/a, cohort_n=n/a.",
      "override_flag": true,
      "override_trigger_codes": [
        "authority_contradicts_catalog_class"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs12916|genotypes|T%2CT",
      "rsid": "rs12916",
      "gene": "HMGCR",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 454,
        "tier1_citation_count": 0,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 98,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=HMGCR, domain=cardiovascular_lipid, citations=454, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs12916|genotypes|T%2CC",
      "rsid": "rs12916",
      "gene": "HMGCR",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 454,
        "tier1_citation_count": 0,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 98,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=HMGCR, domain=cardiovascular_lipid, citations=454, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs12916|genotypes|C%2CC",
      "rsid": "rs12916",
      "gene": "HMGCR",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 454,
        "tier1_citation_count": 0,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 98,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=HMGCR, domain=cardiovascular_lipid, citations=454, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs708272|genotypes|G%2CG",
      "rsid": "rs708272",
      "gene": "CETP (TaqIB)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 59,
        "tier1_citation_count": 0,
        "unique_cohort_count": 35,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CETP (TaqIB), domain=cardiovascular_lipid, citations=59, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs708272|genotypes|G%2CA",
      "rsid": "rs708272",
      "gene": "CETP (TaqIB)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 59,
        "tier1_citation_count": 0,
        "unique_cohort_count": 35,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CETP (TaqIB), domain=cardiovascular_lipid, citations=59, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs708272|genotypes|A%2CA",
      "rsid": "rs708272",
      "gene": "CETP (TaqIB)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 59,
        "tier1_citation_count": 0,
        "unique_cohort_count": 35,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CETP (TaqIB), domain=cardiovascular_lipid, citations=59, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs5882|genotypes|C%2CC",
      "rsid": "rs5882",
      "gene": "CETP (I405V)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 38,
        "tier1_citation_count": 0,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CETP (I405V), domain=cardiovascular_lipid, citations=38, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs5882|genotypes|C%2CT",
      "rsid": "rs5882",
      "gene": "CETP (I405V)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 38,
        "tier1_citation_count": 0,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CETP (I405V), domain=cardiovascular_lipid, citations=38, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs5882|genotypes|T%2CT",
      "rsid": "rs5882",
      "gene": "CETP (I405V)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 38,
        "tier1_citation_count": 0,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CETP (I405V), domain=cardiovascular_lipid, citations=38, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1333049|insights|G%2CG",
      "rsid": "rs1333049",
      "gene": "CDKN2B-AS1",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 54,
        "tier1_citation_count": 1,
        "unique_cohort_count": 41,
        "effect_direction_agreement_pct": 65,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CDKN2B-AS1, domain=cardiovascular_lipid, citations=54, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1333049|insights|G%2CC",
      "rsid": "rs1333049",
      "gene": "CDKN2B-AS1",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 54,
        "tier1_citation_count": 1,
        "unique_cohort_count": 41,
        "effect_direction_agreement_pct": 65,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CDKN2B-AS1, domain=cardiovascular_lipid, citations=54, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1333049|insights|C%2CC",
      "rsid": "rs1333049",
      "gene": "CDKN2B-AS1",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 54,
        "tier1_citation_count": 1,
        "unique_cohort_count": 41,
        "effect_direction_agreement_pct": 65,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CDKN2B-AS1, domain=cardiovascular_lipid, citations=54, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1333049|genotypes|G%2CG",
      "rsid": "rs1333049",
      "gene": "CDKN2B-AS1",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 54,
        "tier1_citation_count": 1,
        "unique_cohort_count": 41,
        "effect_direction_agreement_pct": 65,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CDKN2B-AS1, domain=cardiovascular_lipid, citations=54, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1333049|genotypes|G%2CC",
      "rsid": "rs1333049",
      "gene": "CDKN2B-AS1",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 54,
        "tier1_citation_count": 1,
        "unique_cohort_count": 41,
        "effect_direction_agreement_pct": 65,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CDKN2B-AS1, domain=cardiovascular_lipid, citations=54, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1333049|genotypes|C%2CC",
      "rsid": "rs1333049",
      "gene": "CDKN2B-AS1",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 54,
        "tier1_citation_count": 1,
        "unique_cohort_count": 41,
        "effect_direction_agreement_pct": 65,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CDKN2B-AS1, domain=cardiovascular_lipid, citations=54, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs10757278|insights|A%2CA",
      "rsid": "rs10757278",
      "gene": "CDKN2B-AS1",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 6,
        "tier1_citation_count": 2,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 75,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CDKN2B-AS1, domain=cardiovascular_lipid, citations=6, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs10757278|insights|A%2CG",
      "rsid": "rs10757278",
      "gene": "CDKN2B-AS1",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 6,
        "tier1_citation_count": 2,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 75,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CDKN2B-AS1, domain=cardiovascular_lipid, citations=6, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs10757278|insights|G%2CG",
      "rsid": "rs10757278",
      "gene": "CDKN2B-AS1",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 6,
        "tier1_citation_count": 2,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 75,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CDKN2B-AS1, domain=cardiovascular_lipid, citations=6, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs10757278|genotypes|A%2CA",
      "rsid": "rs10757278",
      "gene": "CDKN2B-AS1",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 6,
        "tier1_citation_count": 2,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 75,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CDKN2B-AS1, domain=cardiovascular_lipid, citations=6, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs10757278|genotypes|A%2CG",
      "rsid": "rs10757278",
      "gene": "CDKN2B-AS1",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 6,
        "tier1_citation_count": 2,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 75,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CDKN2B-AS1, domain=cardiovascular_lipid, citations=6, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs10757278|genotypes|G%2CG",
      "rsid": "rs10757278",
      "gene": "CDKN2B-AS1",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 6,
        "tier1_citation_count": 2,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 75,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CDKN2B-AS1, domain=cardiovascular_lipid, citations=6, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799983|insights|G%2CG",
      "rsid": "rs1799983",
      "gene": "NOS3 / eNOS (Glu298Asp)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 1,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 50,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=NOS3 / eNOS (Glu298Asp), domain=cardiovascular_lipid, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799983|insights|G%2CT",
      "rsid": "rs1799983",
      "gene": "NOS3 / eNOS (Glu298Asp)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 1,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 50,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=NOS3 / eNOS (Glu298Asp), domain=cardiovascular_lipid, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799983|insights|T%2CT",
      "rsid": "rs1799983",
      "gene": "NOS3 / eNOS (Glu298Asp)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 1,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 50,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=NOS3 / eNOS (Glu298Asp), domain=cardiovascular_lipid, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799983|genotypes|G%2CG",
      "rsid": "rs1799983",
      "gene": "NOS3 / eNOS (Glu298Asp)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 1,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 50,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=NOS3 / eNOS (Glu298Asp), domain=cardiovascular_lipid, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799983|genotypes|G%2CT",
      "rsid": "rs1799983",
      "gene": "NOS3 / eNOS (Glu298Asp)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 1,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 50,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=NOS3 / eNOS (Glu298Asp), domain=cardiovascular_lipid, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799983|genotypes|T%2CT",
      "rsid": "rs1799983",
      "gene": "NOS3 / eNOS (Glu298Asp)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 1,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 50,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=NOS3 / eNOS (Glu298Asp), domain=cardiovascular_lipid, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs2070744|insights|T%2CT",
      "rsid": "rs2070744",
      "gene": "NOS3 / eNOS (promoter -786T/C)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 27,
        "tier1_citation_count": 0,
        "unique_cohort_count": 27,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=NOS3 / eNOS (promoter -786T/C), domain=cardiovascular_lipid, citations=27, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs2070744|insights|T%2CC",
      "rsid": "rs2070744",
      "gene": "NOS3 / eNOS (promoter -786T/C)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 27,
        "tier1_citation_count": 0,
        "unique_cohort_count": 27,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=NOS3 / eNOS (promoter -786T/C), domain=cardiovascular_lipid, citations=27, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs2070744|insights|C%2CC",
      "rsid": "rs2070744",
      "gene": "NOS3 / eNOS (promoter -786T/C)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 27,
        "tier1_citation_count": 0,
        "unique_cohort_count": 27,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=NOS3 / eNOS (promoter -786T/C), domain=cardiovascular_lipid, citations=27, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs2070744|genotypes|T%2CT",
      "rsid": "rs2070744",
      "gene": "NOS3 / eNOS (promoter -786T/C)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 27,
        "tier1_citation_count": 0,
        "unique_cohort_count": 27,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=NOS3 / eNOS (promoter -786T/C), domain=cardiovascular_lipid, citations=27, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs2070744|genotypes|T%2CC",
      "rsid": "rs2070744",
      "gene": "NOS3 / eNOS (promoter -786T/C)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 27,
        "tier1_citation_count": 0,
        "unique_cohort_count": 27,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=NOS3 / eNOS (promoter -786T/C), domain=cardiovascular_lipid, citations=27, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs2070744|genotypes|C%2CC",
      "rsid": "rs2070744",
      "gene": "NOS3 / eNOS (promoter -786T/C)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 27,
        "tier1_citation_count": 0,
        "unique_cohort_count": 27,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=NOS3 / eNOS (promoter -786T/C), domain=cardiovascular_lipid, citations=27, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs662|genotypes|G%2CG",
      "rsid": "rs662",
      "gene": "PON1 (Q192R)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 37,
        "tier1_citation_count": 0,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=PON1 (Q192R), domain=cardiovascular_lipid, citations=37, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs662|genotypes|G%2CA",
      "rsid": "rs662",
      "gene": "PON1 (Q192R)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 37,
        "tier1_citation_count": 0,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=PON1 (Q192R), domain=cardiovascular_lipid, citations=37, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs662|genotypes|A%2CA",
      "rsid": "rs662",
      "gene": "PON1 (Q192R)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 37,
        "tier1_citation_count": 0,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=PON1 (Q192R), domain=cardiovascular_lipid, citations=37, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs4149056|genotypes|T%2CT",
      "rsid": "rs4149056",
      "gene": "SLCO1B1 (OATP1B1 V174A)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 412,
        "tier1_citation_count": 0,
        "unique_cohort_count": 39,
        "effect_direction_agreement_pct": 97,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SLCO1B1 (OATP1B1 V174A), domain=cardiovascular_lipid, citations=412, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs4149056|genotypes|T%2CC",
      "rsid": "rs4149056",
      "gene": "SLCO1B1 (OATP1B1 V174A)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 412,
        "tier1_citation_count": 0,
        "unique_cohort_count": 39,
        "effect_direction_agreement_pct": 97,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SLCO1B1 (OATP1B1 V174A), domain=cardiovascular_lipid, citations=412, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs4149056|genotypes|C%2CC",
      "rsid": "rs4149056",
      "gene": "SLCO1B1 (OATP1B1 V174A)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 412,
        "tier1_citation_count": 0,
        "unique_cohort_count": 39,
        "effect_direction_agreement_pct": 97,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SLCO1B1 (OATP1B1 V174A), domain=cardiovascular_lipid, citations=412, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs9923231|insights|G%2CG",
      "rsid": "rs9923231",
      "gene": "VKORC1 (warfarin sensitivity)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 39,
        "tier1_citation_count": 0,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=VKORC1 (warfarin sensitivity), domain=cardiovascular_lipid, citations=39, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs9923231|insights|G%2CA",
      "rsid": "rs9923231",
      "gene": "VKORC1 (warfarin sensitivity)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 39,
        "tier1_citation_count": 0,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=VKORC1 (warfarin sensitivity), domain=cardiovascular_lipid, citations=39, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs9923231|insights|A%2CA",
      "rsid": "rs9923231",
      "gene": "VKORC1 (warfarin sensitivity)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 39,
        "tier1_citation_count": 0,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=VKORC1 (warfarin sensitivity), domain=cardiovascular_lipid, citations=39, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs9923231|genotypes|C%2CC",
      "rsid": "rs9923231",
      "gene": "VKORC1 (warfarin sensitivity)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 39,
        "tier1_citation_count": 0,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=VKORC1 (warfarin sensitivity), domain=cardiovascular_lipid, citations=39, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs9923231|genotypes|C%2CT",
      "rsid": "rs9923231",
      "gene": "VKORC1 (warfarin sensitivity)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 39,
        "tier1_citation_count": 0,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=VKORC1 (warfarin sensitivity), domain=cardiovascular_lipid, citations=39, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs9923231|genotypes|T%2CT",
      "rsid": "rs9923231",
      "gene": "VKORC1 (warfarin sensitivity)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 39,
        "tier1_citation_count": 0,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=VKORC1 (warfarin sensitivity), domain=cardiovascular_lipid, citations=39, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs693|genotypes|G%2CG",
      "rsid": "rs693",
      "gene": "APOB",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Pathogenic"
      ],
      "strength": null,
      "conversation_context": "Authority-graded; condition-associated",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": null,
        "tier1_citation_count": null,
        "unique_cohort_count": null,
        "effect_direction_agreement_pct": null,
        "total_cohort_n": null
      },
      "class_assignment_basis": "Pathogenic per Pass 0 router and class grader consensus: gene=APOB, domain=cardiovascular_lipid, citations=n/a, cohort_n=n/a.",
      "override_flag": true,
      "override_trigger_codes": [
        "authority_contradicts_catalog_class"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs693|genotypes|G%2CA",
      "rsid": "rs693",
      "gene": "APOB",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Pathogenic"
      ],
      "strength": null,
      "conversation_context": "Authority-graded; condition-associated",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": null,
        "tier1_citation_count": null,
        "unique_cohort_count": null,
        "effect_direction_agreement_pct": null,
        "total_cohort_n": null
      },
      "class_assignment_basis": "Pathogenic per Pass 0 router and class grader consensus: gene=APOB, domain=cardiovascular_lipid, citations=n/a, cohort_n=n/a.",
      "override_flag": true,
      "override_trigger_codes": [
        "authority_contradicts_catalog_class"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs693|genotypes|A%2CA",
      "rsid": "rs693",
      "gene": "APOB",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Pathogenic"
      ],
      "strength": null,
      "conversation_context": "Authority-graded; condition-associated",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": null,
        "tier1_citation_count": null,
        "unique_cohort_count": null,
        "effect_direction_agreement_pct": null,
        "total_cohort_n": null
      },
      "class_assignment_basis": "Pathogenic per Pass 0 router and class grader consensus: gene=APOB, domain=cardiovascular_lipid, citations=n/a, cohort_n=n/a.",
      "override_flag": true,
      "override_trigger_codes": [
        "authority_contradicts_catalog_class"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs6025|insights|G%2CG",
      "rsid": "rs6025",
      "gene": "F5 / Factor V Leiden",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 68,
        "tier1_citation_count": 1,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 52,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=F5 / Factor V Leiden, domain=cardiovascular_lipid, citations=68, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs6025|insights|G%2CA",
      "rsid": "rs6025",
      "gene": "F5 / Factor V Leiden",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 68,
        "tier1_citation_count": 1,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 52,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=F5 / Factor V Leiden, domain=cardiovascular_lipid, citations=68, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs6025|insights|A%2CA",
      "rsid": "rs6025",
      "gene": "F5 / Factor V Leiden",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 68,
        "tier1_citation_count": 1,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 52,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=F5 / Factor V Leiden, domain=cardiovascular_lipid, citations=68, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs6025|genotypes|G%2CG",
      "rsid": "rs6025",
      "gene": "F5 / Factor V Leiden",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 68,
        "tier1_citation_count": 1,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 52,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=F5 / Factor V Leiden, domain=cardiovascular_lipid, citations=68, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs6025|genotypes|G%2CA",
      "rsid": "rs6025",
      "gene": "F5 / Factor V Leiden",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 68,
        "tier1_citation_count": 1,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 52,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=F5 / Factor V Leiden, domain=cardiovascular_lipid, citations=68, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs6025|genotypes|A%2CA",
      "rsid": "rs6025",
      "gene": "F5 / Factor V Leiden",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 68,
        "tier1_citation_count": 1,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 52,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=F5 / Factor V Leiden, domain=cardiovascular_lipid, citations=68, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799963|insights|G%2CG",
      "rsid": "rs1799963",
      "gene": "F2 / Prothrombin G20210A",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 72,
        "tier1_citation_count": 0,
        "unique_cohort_count": 37,
        "effect_direction_agreement_pct": 79,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=F2 / Prothrombin G20210A, domain=cardiovascular_lipid, citations=72, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799963|insights|G%2CA",
      "rsid": "rs1799963",
      "gene": "F2 / Prothrombin G20210A",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 72,
        "tier1_citation_count": 0,
        "unique_cohort_count": 37,
        "effect_direction_agreement_pct": 79,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=F2 / Prothrombin G20210A, domain=cardiovascular_lipid, citations=72, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799963|insights|A%2CA",
      "rsid": "rs1799963",
      "gene": "F2 / Prothrombin G20210A",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 72,
        "tier1_citation_count": 0,
        "unique_cohort_count": 37,
        "effect_direction_agreement_pct": 79,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=F2 / Prothrombin G20210A, domain=cardiovascular_lipid, citations=72, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799963|genotypes|G%2CG",
      "rsid": "rs1799963",
      "gene": "F2 / Prothrombin G20210A",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 72,
        "tier1_citation_count": 0,
        "unique_cohort_count": 37,
        "effect_direction_agreement_pct": 79,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=F2 / Prothrombin G20210A, domain=cardiovascular_lipid, citations=72, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799963|genotypes|G%2CA",
      "rsid": "rs1799963",
      "gene": "F2 / Prothrombin G20210A",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 72,
        "tier1_citation_count": 0,
        "unique_cohort_count": 37,
        "effect_direction_agreement_pct": 79,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=F2 / Prothrombin G20210A, domain=cardiovascular_lipid, citations=72, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799963|genotypes|A%2CA",
      "rsid": "rs1799963",
      "gene": "F2 / Prothrombin G20210A",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 72,
        "tier1_citation_count": 0,
        "unique_cohort_count": 37,
        "effect_direction_agreement_pct": 79,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=F2 / Prothrombin G20210A, domain=cardiovascular_lipid, citations=72, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799945|insights|C%2CC",
      "rsid": "rs1799945",
      "gene": "HFE (C282Y)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 101,
        "tier1_citation_count": 1,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 98,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=HFE (C282Y), domain=cardiovascular_lipid, citations=101, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799945|insights|C%2CG",
      "rsid": "rs1799945",
      "gene": "HFE (C282Y)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 101,
        "tier1_citation_count": 1,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 98,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=HFE (C282Y), domain=cardiovascular_lipid, citations=101, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799945|insights|G%2CG",
      "rsid": "rs1799945",
      "gene": "HFE (C282Y)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 101,
        "tier1_citation_count": 1,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 98,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=HFE (C282Y), domain=cardiovascular_lipid, citations=101, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799945|genotypes|C%2CC",
      "rsid": "rs1799945",
      "gene": "HFE (C282Y)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 101,
        "tier1_citation_count": 1,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 98,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=HFE (C282Y), domain=cardiovascular_lipid, citations=101, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799945|genotypes|C%2CG",
      "rsid": "rs1799945",
      "gene": "HFE (C282Y)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 101,
        "tier1_citation_count": 1,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 98,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=HFE (C282Y), domain=cardiovascular_lipid, citations=101, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799945|genotypes|G%2CG",
      "rsid": "rs1799945",
      "gene": "HFE (C282Y)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 101,
        "tier1_citation_count": 1,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 98,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=HFE (C282Y), domain=cardiovascular_lipid, citations=101, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1800562|insights|G%2CG",
      "rsid": "rs1800562",
      "gene": "HFE (H63D)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 216,
        "tier1_citation_count": 1,
        "unique_cohort_count": 40,
        "effect_direction_agreement_pct": 93,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=HFE (H63D), domain=cardiovascular_lipid, citations=216, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1800562|insights|G%2CA",
      "rsid": "rs1800562",
      "gene": "HFE (H63D)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 216,
        "tier1_citation_count": 1,
        "unique_cohort_count": 40,
        "effect_direction_agreement_pct": 93,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=HFE (H63D), domain=cardiovascular_lipid, citations=216, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1800562|insights|A%2CA",
      "rsid": "rs1800562",
      "gene": "HFE (H63D)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 216,
        "tier1_citation_count": 1,
        "unique_cohort_count": 40,
        "effect_direction_agreement_pct": 93,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=HFE (H63D), domain=cardiovascular_lipid, citations=216, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1800562|genotypes|G%2CG",
      "rsid": "rs1800562",
      "gene": "HFE (H63D)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 216,
        "tier1_citation_count": 1,
        "unique_cohort_count": 40,
        "effect_direction_agreement_pct": 93,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=HFE (H63D), domain=cardiovascular_lipid, citations=216, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1800562|genotypes|G%2CA",
      "rsid": "rs1800562",
      "gene": "HFE (H63D)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 216,
        "tier1_citation_count": 1,
        "unique_cohort_count": 40,
        "effect_direction_agreement_pct": 93,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=HFE (H63D), domain=cardiovascular_lipid, citations=216, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1800562|genotypes|A%2CA",
      "rsid": "rs1800562",
      "gene": "HFE (H63D)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 216,
        "tier1_citation_count": 1,
        "unique_cohort_count": 40,
        "effect_direction_agreement_pct": 93,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=HFE (H63D), domain=cardiovascular_lipid, citations=216, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799752|insights|I%2CI",
      "rsid": "rs1799752",
      "gene": "ACE (Insertion/Deletion)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ACE (Insertion/Deletion), domain=cardiovascular_lipid, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799752|insights|I%2CD",
      "rsid": "rs1799752",
      "gene": "ACE (Insertion/Deletion)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ACE (Insertion/Deletion), domain=cardiovascular_lipid, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799752|insights|D%2CD",
      "rsid": "rs1799752",
      "gene": "ACE (Insertion/Deletion)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ACE (Insertion/Deletion), domain=cardiovascular_lipid, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799752|genotypes|A%2CA",
      "rsid": "rs1799752",
      "gene": "ACE (Insertion/Deletion)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ACE (Insertion/Deletion), domain=cardiovascular_lipid, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799752|genotypes|A%2CINDEL",
      "rsid": "rs1799752",
      "gene": "ACE (Insertion/Deletion)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ACE (Insertion/Deletion), domain=cardiovascular_lipid, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs1799752|genotypes|INDEL%2CINDEL",
      "rsid": "rs1799752",
      "gene": "ACE (Insertion/Deletion)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ACE (Insertion/Deletion), domain=cardiovascular_lipid, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs174537|insights|G%2CG",
      "rsid": "rs174537",
      "gene": "FADS1 (fatty acid desaturase 1)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 208,
        "tier1_citation_count": 0,
        "unique_cohort_count": 41,
        "effect_direction_agreement_pct": 96,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FADS1 (fatty acid desaturase 1), domain=cardiovascular_lipid, citations=208, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs174537|insights|G%2CT",
      "rsid": "rs174537",
      "gene": "FADS1 (fatty acid desaturase 1)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 208,
        "tier1_citation_count": 0,
        "unique_cohort_count": 41,
        "effect_direction_agreement_pct": 96,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FADS1 (fatty acid desaturase 1), domain=cardiovascular_lipid, citations=208, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs174537|insights|T%2CT",
      "rsid": "rs174537",
      "gene": "FADS1 (fatty acid desaturase 1)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 208,
        "tier1_citation_count": 0,
        "unique_cohort_count": 41,
        "effect_direction_agreement_pct": 96,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FADS1 (fatty acid desaturase 1), domain=cardiovascular_lipid, citations=208, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs174537|genotypes|G%2CG",
      "rsid": "rs174537",
      "gene": "FADS1 (fatty acid desaturase 1)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 208,
        "tier1_citation_count": 0,
        "unique_cohort_count": 41,
        "effect_direction_agreement_pct": 96,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FADS1 (fatty acid desaturase 1), domain=cardiovascular_lipid, citations=208, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs174537|genotypes|G%2CT",
      "rsid": "rs174537",
      "gene": "FADS1 (fatty acid desaturase 1)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 208,
        "tier1_citation_count": 0,
        "unique_cohort_count": 41,
        "effect_direction_agreement_pct": 96,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FADS1 (fatty acid desaturase 1), domain=cardiovascular_lipid, citations=208, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "cardiovascular_lipid|rs174537|genotypes|T%2CT",
      "rsid": "rs174537",
      "gene": "FADS1 (fatty acid desaturase 1)",
      "module_id": "cardiovascular_lipid",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 208,
        "tier1_citation_count": 0,
        "unique_cohort_count": 41,
        "effect_direction_agreement_pct": 96,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FADS1 (fatty acid desaturase 1), domain=cardiovascular_lipid, citations=208, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs75932628|insights|C%2CC",
      "rsid": "rs75932628",
      "gene": "TREM2 (R47H)",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Well-replicated",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Routine discussion",
      "feature_summary": {
        "citation_count": 12,
        "tier1_citation_count": 2,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TREM2 (R47H), domain=alzheimers_clearance, citations=12, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs75932628|insights|C%2CA",
      "rsid": "rs75932628",
      "gene": "TREM2 (R47H)",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Well-replicated",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Routine discussion",
      "feature_summary": {
        "citation_count": 12,
        "tier1_citation_count": 2,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TREM2 (R47H), domain=alzheimers_clearance, citations=12, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs75932628|genotypes|G%2CG",
      "rsid": "rs75932628",
      "gene": "TREM2 (R47H)",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Well-replicated",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Routine discussion",
      "feature_summary": {
        "citation_count": 12,
        "tier1_citation_count": 2,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TREM2 (R47H), domain=alzheimers_clearance, citations=12, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs75932628|genotypes|G%2CA",
      "rsid": "rs75932628",
      "gene": "TREM2 (R47H)",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Well-replicated",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Routine discussion",
      "feature_summary": {
        "citation_count": 12,
        "tier1_citation_count": 2,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TREM2 (R47H), domain=alzheimers_clearance, citations=12, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs75932628|genotypes|A%2CA",
      "rsid": "rs75932628",
      "gene": "TREM2 (R47H)",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Well-replicated",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Routine discussion",
      "feature_summary": {
        "citation_count": 12,
        "tier1_citation_count": 2,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TREM2 (R47H), domain=alzheimers_clearance, citations=12, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs11136000|insights|T%2CT",
      "rsid": "rs11136000",
      "gene": "CLU / Clusterin",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Mixed evidence",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 6,
        "tier1_citation_count": 3,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 67,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CLU / Clusterin, domain=alzheimers_clearance, citations=6, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs11136000|insights|C%2CT",
      "rsid": "rs11136000",
      "gene": "CLU / Clusterin",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Mixed evidence",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 6,
        "tier1_citation_count": 3,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 67,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CLU / Clusterin, domain=alzheimers_clearance, citations=6, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs11136000|insights|C%2CC",
      "rsid": "rs11136000",
      "gene": "CLU / Clusterin",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Mixed evidence",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 6,
        "tier1_citation_count": 3,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 67,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CLU / Clusterin, domain=alzheimers_clearance, citations=6, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs11136000|genotypes|C%2CC",
      "rsid": "rs11136000",
      "gene": "CLU / Clusterin",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Mixed evidence",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 6,
        "tier1_citation_count": 3,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 67,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CLU / Clusterin, domain=alzheimers_clearance, citations=6, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs11136000|genotypes|C%2CT",
      "rsid": "rs11136000",
      "gene": "CLU / Clusterin",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Mixed evidence",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 6,
        "tier1_citation_count": 3,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 67,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CLU / Clusterin, domain=alzheimers_clearance, citations=6, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs11136000|genotypes|T%2CT",
      "rsid": "rs11136000",
      "gene": "CLU / Clusterin",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Mixed evidence",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 6,
        "tier1_citation_count": 3,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 67,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CLU / Clusterin, domain=alzheimers_clearance, citations=6, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs3851179|insights|G%2CG",
      "rsid": "rs3851179",
      "gene": "PICALM",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Mixed evidence",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 10,
        "tier1_citation_count": 2,
        "unique_cohort_count": 6,
        "effect_direction_agreement_pct": 50,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=PICALM, domain=alzheimers_clearance, citations=10, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs3851179|insights|G%2CA",
      "rsid": "rs3851179",
      "gene": "PICALM",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Mixed evidence",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 10,
        "tier1_citation_count": 2,
        "unique_cohort_count": 6,
        "effect_direction_agreement_pct": 50,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=PICALM, domain=alzheimers_clearance, citations=10, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs3851179|insights|A%2CA",
      "rsid": "rs3851179",
      "gene": "PICALM",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Mixed evidence",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 10,
        "tier1_citation_count": 2,
        "unique_cohort_count": 6,
        "effect_direction_agreement_pct": 50,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=PICALM, domain=alzheimers_clearance, citations=10, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs3851179|genotypes|A%2CA",
      "rsid": "rs3851179",
      "gene": "PICALM",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Mixed evidence",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 10,
        "tier1_citation_count": 2,
        "unique_cohort_count": 6,
        "effect_direction_agreement_pct": 50,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=PICALM, domain=alzheimers_clearance, citations=10, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs3851179|genotypes|A%2CG",
      "rsid": "rs3851179",
      "gene": "PICALM",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Mixed evidence",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 10,
        "tier1_citation_count": 2,
        "unique_cohort_count": 6,
        "effect_direction_agreement_pct": 50,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=PICALM, domain=alzheimers_clearance, citations=10, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs3851179|genotypes|G%2CG",
      "rsid": "rs3851179",
      "gene": "PICALM",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Mixed evidence",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 10,
        "tier1_citation_count": 2,
        "unique_cohort_count": 6,
        "effect_direction_agreement_pct": 50,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=PICALM, domain=alzheimers_clearance, citations=10, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs7561528|insights|G%2CG",
      "rsid": "rs7561528",
      "gene": "BIN1",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 1,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=BIN1, domain=alzheimers_clearance, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs7561528|insights|G%2CA",
      "rsid": "rs7561528",
      "gene": "BIN1",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 1,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=BIN1, domain=alzheimers_clearance, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs7561528|insights|A%2CA",
      "rsid": "rs7561528",
      "gene": "BIN1",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 1,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=BIN1, domain=alzheimers_clearance, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs7561528|genotypes|A%2CA",
      "rsid": "rs7561528",
      "gene": "BIN1",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 1,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=BIN1, domain=alzheimers_clearance, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs7561528|genotypes|A%2CG",
      "rsid": "rs7561528",
      "gene": "BIN1",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 1,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=BIN1, domain=alzheimers_clearance, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs7561528|genotypes|G%2CG",
      "rsid": "rs7561528",
      "gene": "BIN1",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 1,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=BIN1, domain=alzheimers_clearance, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs6656401|insights|G%2CG",
      "rsid": "rs6656401",
      "gene": "CR1 (Complement Receptor 1)",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Well-replicated",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Routine discussion",
      "feature_summary": {
        "citation_count": 14,
        "tier1_citation_count": 2,
        "unique_cohort_count": 6,
        "effect_direction_agreement_pct": 82,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CR1 (Complement Receptor 1), domain=alzheimers_clearance, citations=14, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs6656401|insights|G%2CA",
      "rsid": "rs6656401",
      "gene": "CR1 (Complement Receptor 1)",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Well-replicated",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Routine discussion",
      "feature_summary": {
        "citation_count": 14,
        "tier1_citation_count": 2,
        "unique_cohort_count": 6,
        "effect_direction_agreement_pct": 82,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CR1 (Complement Receptor 1), domain=alzheimers_clearance, citations=14, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs6656401|insights|A%2CA",
      "rsid": "rs6656401",
      "gene": "CR1 (Complement Receptor 1)",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Well-replicated",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Routine discussion",
      "feature_summary": {
        "citation_count": 14,
        "tier1_citation_count": 2,
        "unique_cohort_count": 6,
        "effect_direction_agreement_pct": 82,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CR1 (Complement Receptor 1), domain=alzheimers_clearance, citations=14, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs6656401|genotypes|A%2CA",
      "rsid": "rs6656401",
      "gene": "CR1 (Complement Receptor 1)",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Well-replicated",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Routine discussion",
      "feature_summary": {
        "citation_count": 14,
        "tier1_citation_count": 2,
        "unique_cohort_count": 6,
        "effect_direction_agreement_pct": 82,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CR1 (Complement Receptor 1), domain=alzheimers_clearance, citations=14, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs6656401|genotypes|A%2CG",
      "rsid": "rs6656401",
      "gene": "CR1 (Complement Receptor 1)",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Well-replicated",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Routine discussion",
      "feature_summary": {
        "citation_count": 14,
        "tier1_citation_count": 2,
        "unique_cohort_count": 6,
        "effect_direction_agreement_pct": 82,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CR1 (Complement Receptor 1), domain=alzheimers_clearance, citations=14, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs6656401|genotypes|G%2CG",
      "rsid": "rs6656401",
      "gene": "CR1 (Complement Receptor 1)",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Well-replicated",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Routine discussion",
      "feature_summary": {
        "citation_count": 14,
        "tier1_citation_count": 2,
        "unique_cohort_count": 6,
        "effect_direction_agreement_pct": 82,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CR1 (Complement Receptor 1), domain=alzheimers_clearance, citations=14, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs3764650|insights|T%2CT",
      "rsid": "rs3764650",
      "gene": "ABCA7",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 6,
        "tier1_citation_count": 2,
        "unique_cohort_count": 6,
        "effect_direction_agreement_pct": 75,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ABCA7, domain=alzheimers_clearance, citations=6, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs3764650|insights|T%2CG",
      "rsid": "rs3764650",
      "gene": "ABCA7",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 6,
        "tier1_citation_count": 2,
        "unique_cohort_count": 6,
        "effect_direction_agreement_pct": 75,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ABCA7, domain=alzheimers_clearance, citations=6, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs3764650|insights|G%2CG",
      "rsid": "rs3764650",
      "gene": "ABCA7",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 6,
        "tier1_citation_count": 2,
        "unique_cohort_count": 6,
        "effect_direction_agreement_pct": 75,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ABCA7, domain=alzheimers_clearance, citations=6, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs3764650|genotypes|G%2CG",
      "rsid": "rs3764650",
      "gene": "ABCA7",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 6,
        "tier1_citation_count": 2,
        "unique_cohort_count": 6,
        "effect_direction_agreement_pct": 75,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ABCA7, domain=alzheimers_clearance, citations=6, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs3764650|genotypes|G%2CT",
      "rsid": "rs3764650",
      "gene": "ABCA7",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 6,
        "tier1_citation_count": 2,
        "unique_cohort_count": 6,
        "effect_direction_agreement_pct": 75,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ABCA7, domain=alzheimers_clearance, citations=6, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs3764650|genotypes|T%2CT",
      "rsid": "rs3764650",
      "gene": "ABCA7",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 6,
        "tier1_citation_count": 2,
        "unique_cohort_count": 6,
        "effect_direction_agreement_pct": 75,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ABCA7, domain=alzheimers_clearance, citations=6, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs641120|insights|T%2CT",
      "rsid": "rs641120",
      "gene": "SORL1",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 26,
        "tier1_citation_count": 1,
        "unique_cohort_count": 26,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SORL1, domain=alzheimers_clearance, citations=26, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs641120|insights|C%2CT",
      "rsid": "rs641120",
      "gene": "SORL1",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 26,
        "tier1_citation_count": 1,
        "unique_cohort_count": 26,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SORL1, domain=alzheimers_clearance, citations=26, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs641120|insights|C%2CC",
      "rsid": "rs641120",
      "gene": "SORL1",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 26,
        "tier1_citation_count": 1,
        "unique_cohort_count": 26,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SORL1, domain=alzheimers_clearance, citations=26, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs641120|genotypes|C%2CC",
      "rsid": "rs641120",
      "gene": "SORL1",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 26,
        "tier1_citation_count": 1,
        "unique_cohort_count": 26,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SORL1, domain=alzheimers_clearance, citations=26, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs641120|genotypes|C%2CT",
      "rsid": "rs641120",
      "gene": "SORL1",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 26,
        "tier1_citation_count": 1,
        "unique_cohort_count": 26,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SORL1, domain=alzheimers_clearance, citations=26, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "alzheimers_clearance|rs641120|genotypes|T%2CT",
      "rsid": "rs641120",
      "gene": "SORL1",
      "module_id": "alzheimers_clearance",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 26,
        "tier1_citation_count": 1,
        "unique_cohort_count": 26,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SORL1, domain=alzheimers_clearance, citations=26, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs4680|insights|G%2CG",
      "rsid": "rs4680",
      "gene": "COMT (Val158Met)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 69,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 97,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=COMT (Val158Met), domain=neuro_pharmacogenomics, citations=69, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs4680|insights|G%2CA",
      "rsid": "rs4680",
      "gene": "COMT (Val158Met)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 69,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 97,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=COMT (Val158Met), domain=neuro_pharmacogenomics, citations=69, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs4680|insights|A%2CA",
      "rsid": "rs4680",
      "gene": "COMT (Val158Met)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 69,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 97,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=COMT (Val158Met), domain=neuro_pharmacogenomics, citations=69, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs4680|genotypes|G%2CG",
      "rsid": "rs4680",
      "gene": "COMT (Val158Met)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 69,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 97,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=COMT (Val158Met), domain=neuro_pharmacogenomics, citations=69, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs4680|genotypes|G%2CA",
      "rsid": "rs4680",
      "gene": "COMT (Val158Met)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 69,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 97,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=COMT (Val158Met), domain=neuro_pharmacogenomics, citations=69, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs4680|genotypes|A%2CA",
      "rsid": "rs4680",
      "gene": "COMT (Val158Met)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 69,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 97,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=COMT (Val158Met), domain=neuro_pharmacogenomics, citations=69, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs3749034|insights|G%2CG",
      "rsid": "rs3749034",
      "gene": "GAD1 (GAD67)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 28,
        "tier1_citation_count": 0,
        "unique_cohort_count": 28,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=GAD1 (GAD67), domain=neuro_pharmacogenomics, citations=28, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs3749034|insights|G%2CA",
      "rsid": "rs3749034",
      "gene": "GAD1 (GAD67)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 28,
        "tier1_citation_count": 0,
        "unique_cohort_count": 28,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=GAD1 (GAD67), domain=neuro_pharmacogenomics, citations=28, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs3749034|insights|A%2CA",
      "rsid": "rs3749034",
      "gene": "GAD1 (GAD67)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 28,
        "tier1_citation_count": 0,
        "unique_cohort_count": 28,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=GAD1 (GAD67), domain=neuro_pharmacogenomics, citations=28, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs3749034|genotypes|A%2CA",
      "rsid": "rs3749034",
      "gene": "GAD1 (GAD67)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 28,
        "tier1_citation_count": 0,
        "unique_cohort_count": 28,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=GAD1 (GAD67), domain=neuro_pharmacogenomics, citations=28, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs3749034|genotypes|A%2CG",
      "rsid": "rs3749034",
      "gene": "GAD1 (GAD67)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 28,
        "tier1_citation_count": 0,
        "unique_cohort_count": 28,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=GAD1 (GAD67), domain=neuro_pharmacogenomics, citations=28, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs3749034|genotypes|G%2CG",
      "rsid": "rs3749034",
      "gene": "GAD1 (GAD67)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 28,
        "tier1_citation_count": 0,
        "unique_cohort_count": 28,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=GAD1 (GAD67), domain=neuro_pharmacogenomics, citations=28, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs6265|insights|G%2CG",
      "rsid": "rs6265",
      "gene": "BDNF (Val66Met)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 111,
        "tier1_citation_count": 1,
        "unique_cohort_count": 40,
        "effect_direction_agreement_pct": 94,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=BDNF (Val66Met), domain=neuro_pharmacogenomics, citations=111, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs6265|insights|G%2CA",
      "rsid": "rs6265",
      "gene": "BDNF (Val66Met)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 111,
        "tier1_citation_count": 1,
        "unique_cohort_count": 40,
        "effect_direction_agreement_pct": 94,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=BDNF (Val66Met), domain=neuro_pharmacogenomics, citations=111, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs6265|insights|A%2CA",
      "rsid": "rs6265",
      "gene": "BDNF (Val66Met)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 111,
        "tier1_citation_count": 1,
        "unique_cohort_count": 40,
        "effect_direction_agreement_pct": 94,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=BDNF (Val66Met), domain=neuro_pharmacogenomics, citations=111, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs6265|genotypes|G%2CG",
      "rsid": "rs6265",
      "gene": "BDNF (Val66Met)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 111,
        "tier1_citation_count": 1,
        "unique_cohort_count": 40,
        "effect_direction_agreement_pct": 94,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=BDNF (Val66Met), domain=neuro_pharmacogenomics, citations=111, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs6265|genotypes|G%2CA",
      "rsid": "rs6265",
      "gene": "BDNF (Val66Met)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 111,
        "tier1_citation_count": 1,
        "unique_cohort_count": 40,
        "effect_direction_agreement_pct": 94,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=BDNF (Val66Met), domain=neuro_pharmacogenomics, citations=111, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs6265|genotypes|A%2CA",
      "rsid": "rs6265",
      "gene": "BDNF (Val66Met)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 111,
        "tier1_citation_count": 1,
        "unique_cohort_count": 40,
        "effect_direction_agreement_pct": 94,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=BDNF (Val66Met), domain=neuro_pharmacogenomics, citations=111, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1044396|insights|C%2CC",
      "rsid": "rs1044396",
      "gene": "CHRNA4 (nicotinic acetylcholine receptor alpha-4)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CHRNA4 (nicotinic acetylcholine receptor alpha-4), domain=neuro_pharmacogenomics, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1044396|insights|C%2CT",
      "rsid": "rs1044396",
      "gene": "CHRNA4 (nicotinic acetylcholine receptor alpha-4)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CHRNA4 (nicotinic acetylcholine receptor alpha-4), domain=neuro_pharmacogenomics, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1044396|insights|T%2CT",
      "rsid": "rs1044396",
      "gene": "CHRNA4 (nicotinic acetylcholine receptor alpha-4)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CHRNA4 (nicotinic acetylcholine receptor alpha-4), domain=neuro_pharmacogenomics, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1044396|genotypes|C%2CC",
      "rsid": "rs1044396",
      "gene": "CHRNA4 (nicotinic acetylcholine receptor alpha-4)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CHRNA4 (nicotinic acetylcholine receptor alpha-4), domain=neuro_pharmacogenomics, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1044396|genotypes|C%2CT",
      "rsid": "rs1044396",
      "gene": "CHRNA4 (nicotinic acetylcholine receptor alpha-4)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CHRNA4 (nicotinic acetylcholine receptor alpha-4), domain=neuro_pharmacogenomics, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1044396|genotypes|T%2CT",
      "rsid": "rs1044396",
      "gene": "CHRNA4 (nicotinic acetylcholine receptor alpha-4)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CHRNA4 (nicotinic acetylcholine receptor alpha-4), domain=neuro_pharmacogenomics, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1801260|insights|T%2CT",
      "rsid": "rs1801260",
      "gene": "CLOCK",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CLOCK, domain=neuro_pharmacogenomics, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1801260|insights|T%2CC",
      "rsid": "rs1801260",
      "gene": "CLOCK",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CLOCK, domain=neuro_pharmacogenomics, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1801260|insights|C%2CC",
      "rsid": "rs1801260",
      "gene": "CLOCK",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CLOCK, domain=neuro_pharmacogenomics, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1801260|genotypes|A%2CA",
      "rsid": "rs1801260",
      "gene": "CLOCK",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CLOCK, domain=neuro_pharmacogenomics, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1801260|genotypes|A%2CG",
      "rsid": "rs1801260",
      "gene": "CLOCK",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CLOCK, domain=neuro_pharmacogenomics, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1801260|genotypes|G%2CG",
      "rsid": "rs1801260",
      "gene": "CLOCK",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CLOCK, domain=neuro_pharmacogenomics, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs5751876|insights|C%2CC",
      "rsid": "rs5751876",
      "gene": "ADORA2A (A2A adenosine receptor)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 2,
        "tier1_citation_count": 1,
        "unique_cohort_count": 2,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ADORA2A (A2A adenosine receptor), domain=neuro_pharmacogenomics, citations=2, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs5751876|insights|C%2CT",
      "rsid": "rs5751876",
      "gene": "ADORA2A (A2A adenosine receptor)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 2,
        "tier1_citation_count": 1,
        "unique_cohort_count": 2,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ADORA2A (A2A adenosine receptor), domain=neuro_pharmacogenomics, citations=2, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs5751876|insights|T%2CT",
      "rsid": "rs5751876",
      "gene": "ADORA2A (A2A adenosine receptor)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 2,
        "tier1_citation_count": 1,
        "unique_cohort_count": 2,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ADORA2A (A2A adenosine receptor), domain=neuro_pharmacogenomics, citations=2, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs5751876|genotypes|T%2CT",
      "rsid": "rs5751876",
      "gene": "ADORA2A (A2A adenosine receptor)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 2,
        "tier1_citation_count": 1,
        "unique_cohort_count": 2,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ADORA2A (A2A adenosine receptor), domain=neuro_pharmacogenomics, citations=2, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs5751876|genotypes|T%2CC",
      "rsid": "rs5751876",
      "gene": "ADORA2A (A2A adenosine receptor)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 2,
        "tier1_citation_count": 1,
        "unique_cohort_count": 2,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ADORA2A (A2A adenosine receptor), domain=neuro_pharmacogenomics, citations=2, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs5751876|genotypes|C%2CC",
      "rsid": "rs5751876",
      "gene": "ADORA2A (A2A adenosine receptor)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 2,
        "tier1_citation_count": 1,
        "unique_cohort_count": 2,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ADORA2A (A2A adenosine receptor), domain=neuro_pharmacogenomics, citations=2, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs762551|insights|A%2CA",
      "rsid": "rs762551",
      "gene": "CYP1A2 (caffeine/drug metabolism)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 35,
        "tier1_citation_count": 1,
        "unique_cohort_count": 35,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP1A2 (caffeine/drug metabolism), domain=neuro_pharmacogenomics, citations=35, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs762551|insights|A%2CC",
      "rsid": "rs762551",
      "gene": "CYP1A2 (caffeine/drug metabolism)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 35,
        "tier1_citation_count": 1,
        "unique_cohort_count": 35,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP1A2 (caffeine/drug metabolism), domain=neuro_pharmacogenomics, citations=35, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs762551|insights|C%2CC",
      "rsid": "rs762551",
      "gene": "CYP1A2 (caffeine/drug metabolism)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 35,
        "tier1_citation_count": 1,
        "unique_cohort_count": 35,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP1A2 (caffeine/drug metabolism), domain=neuro_pharmacogenomics, citations=35, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs762551|genotypes|A%2CA",
      "rsid": "rs762551",
      "gene": "CYP1A2 (caffeine/drug metabolism)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 35,
        "tier1_citation_count": 1,
        "unique_cohort_count": 35,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP1A2 (caffeine/drug metabolism), domain=neuro_pharmacogenomics, citations=35, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs762551|genotypes|A%2CC",
      "rsid": "rs762551",
      "gene": "CYP1A2 (caffeine/drug metabolism)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 35,
        "tier1_citation_count": 1,
        "unique_cohort_count": 35,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP1A2 (caffeine/drug metabolism), domain=neuro_pharmacogenomics, citations=35, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs762551|genotypes|C%2CC",
      "rsid": "rs762551",
      "gene": "CYP1A2 (caffeine/drug metabolism)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 35,
        "tier1_citation_count": 1,
        "unique_cohort_count": 35,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP1A2 (caffeine/drug metabolism), domain=neuro_pharmacogenomics, citations=35, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs12248560|genotypes|C%2CC",
      "rsid": "rs12248560",
      "gene": "CYP2C19 (*17 rapid metabolizer allele)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP2C19 (*17 rapid metabolizer allele), domain=neuro_pharmacogenomics, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs12248560|genotypes|C%2CT",
      "rsid": "rs12248560",
      "gene": "CYP2C19 (*17 rapid metabolizer allele)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP2C19 (*17 rapid metabolizer allele), domain=neuro_pharmacogenomics, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs12248560|genotypes|T%2CT",
      "rsid": "rs12248560",
      "gene": "CYP2C19 (*17 rapid metabolizer allele)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP2C19 (*17 rapid metabolizer allele), domain=neuro_pharmacogenomics, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1057910|insights|A%2CA",
      "rsid": "rs1057910",
      "gene": "CYP2C9 (*3 poor metabolizer allele)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 35,
        "tier1_citation_count": 0,
        "unique_cohort_count": 35,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP2C9 (*3 poor metabolizer allele), domain=neuro_pharmacogenomics, citations=35, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1057910|insights|A%2CC",
      "rsid": "rs1057910",
      "gene": "CYP2C9 (*3 poor metabolizer allele)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 35,
        "tier1_citation_count": 0,
        "unique_cohort_count": 35,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP2C9 (*3 poor metabolizer allele), domain=neuro_pharmacogenomics, citations=35, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1057910|insights|C%2CC",
      "rsid": "rs1057910",
      "gene": "CYP2C9 (*3 poor metabolizer allele)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 35,
        "tier1_citation_count": 0,
        "unique_cohort_count": 35,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP2C9 (*3 poor metabolizer allele), domain=neuro_pharmacogenomics, citations=35, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1057910|genotypes|A%2CA",
      "rsid": "rs1057910",
      "gene": "CYP2C9 (*3 poor metabolizer allele)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 35,
        "tier1_citation_count": 0,
        "unique_cohort_count": 35,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP2C9 (*3 poor metabolizer allele), domain=neuro_pharmacogenomics, citations=35, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1057910|genotypes|A%2CC",
      "rsid": "rs1057910",
      "gene": "CYP2C9 (*3 poor metabolizer allele)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 35,
        "tier1_citation_count": 0,
        "unique_cohort_count": 35,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP2C9 (*3 poor metabolizer allele), domain=neuro_pharmacogenomics, citations=35, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1057910|genotypes|C%2CC",
      "rsid": "rs1057910",
      "gene": "CYP2C9 (*3 poor metabolizer allele)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 35,
        "tier1_citation_count": 0,
        "unique_cohort_count": 35,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP2C9 (*3 poor metabolizer allele), domain=neuro_pharmacogenomics, citations=35, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs2032582|genotypes|G%2CG",
      "rsid": "rs2032582",
      "gene": "ABCB1 / MDR1 / P-glycoprotein",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 30,
        "tier1_citation_count": 0,
        "unique_cohort_count": 30,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ABCB1 / MDR1 / P-glycoprotein, domain=neuro_pharmacogenomics, citations=30, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs2032582|genotypes|G%2CT",
      "rsid": "rs2032582",
      "gene": "ABCB1 / MDR1 / P-glycoprotein",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 30,
        "tier1_citation_count": 0,
        "unique_cohort_count": 30,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ABCB1 / MDR1 / P-glycoprotein, domain=neuro_pharmacogenomics, citations=30, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs2032582|genotypes|T%2CT",
      "rsid": "rs2032582",
      "gene": "ABCB1 / MDR1 / P-glycoprotein",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 30,
        "tier1_citation_count": 0,
        "unique_cohort_count": 30,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ABCB1 / MDR1 / P-glycoprotein, domain=neuro_pharmacogenomics, citations=30, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs324420|insights|C%2CC",
      "rsid": "rs324420",
      "gene": "FAAH (fatty acid amide hydrolase)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 76,
        "tier1_citation_count": 0,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FAAH (fatty acid amide hydrolase), domain=neuro_pharmacogenomics, citations=76, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs324420|insights|C%2CA",
      "rsid": "rs324420",
      "gene": "FAAH (fatty acid amide hydrolase)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 76,
        "tier1_citation_count": 0,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FAAH (fatty acid amide hydrolase), domain=neuro_pharmacogenomics, citations=76, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs324420|insights|A%2CA",
      "rsid": "rs324420",
      "gene": "FAAH (fatty acid amide hydrolase)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 76,
        "tier1_citation_count": 0,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FAAH (fatty acid amide hydrolase), domain=neuro_pharmacogenomics, citations=76, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs324420|genotypes|A%2CA",
      "rsid": "rs324420",
      "gene": "FAAH (fatty acid amide hydrolase)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 76,
        "tier1_citation_count": 0,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FAAH (fatty acid amide hydrolase), domain=neuro_pharmacogenomics, citations=76, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs324420|genotypes|A%2CC",
      "rsid": "rs324420",
      "gene": "FAAH (fatty acid amide hydrolase)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 76,
        "tier1_citation_count": 0,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FAAH (fatty acid amide hydrolase), domain=neuro_pharmacogenomics, citations=76, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs324420|genotypes|C%2CC",
      "rsid": "rs324420",
      "gene": "FAAH (fatty acid amide hydrolase)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 76,
        "tier1_citation_count": 0,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FAAH (fatty acid amide hydrolase), domain=neuro_pharmacogenomics, citations=76, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs2494732|genotypes|C%2CC",
      "rsid": "rs2494732",
      "gene": "AKT1",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 29,
        "tier1_citation_count": 0,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=AKT1, domain=neuro_pharmacogenomics, citations=29, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs2494732|genotypes|C%2CT",
      "rsid": "rs2494732",
      "gene": "AKT1",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 29,
        "tier1_citation_count": 0,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=AKT1, domain=neuro_pharmacogenomics, citations=29, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs2494732|genotypes|T%2CT",
      "rsid": "rs2494732",
      "gene": "AKT1",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 29,
        "tier1_citation_count": 0,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=AKT1, domain=neuro_pharmacogenomics, citations=29, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1800497|insights|C%2CC",
      "rsid": "rs1800497",
      "gene": "ANKK1/DRD2 (Taq1A)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 1,
        "unique_cohort_count": 33,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ANKK1/DRD2 (Taq1A), domain=neuro_pharmacogenomics, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1800497|insights|C%2CT",
      "rsid": "rs1800497",
      "gene": "ANKK1/DRD2 (Taq1A)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 1,
        "unique_cohort_count": 33,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ANKK1/DRD2 (Taq1A), domain=neuro_pharmacogenomics, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1800497|insights|T%2CT",
      "rsid": "rs1800497",
      "gene": "ANKK1/DRD2 (Taq1A)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 1,
        "unique_cohort_count": 33,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ANKK1/DRD2 (Taq1A), domain=neuro_pharmacogenomics, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1800497|genotypes|G%2CG",
      "rsid": "rs1800497",
      "gene": "ANKK1/DRD2 (Taq1A)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 1,
        "unique_cohort_count": 33,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ANKK1/DRD2 (Taq1A), domain=neuro_pharmacogenomics, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1800497|genotypes|G%2CA",
      "rsid": "rs1800497",
      "gene": "ANKK1/DRD2 (Taq1A)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 1,
        "unique_cohort_count": 33,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ANKK1/DRD2 (Taq1A), domain=neuro_pharmacogenomics, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1800497|genotypes|A%2CA",
      "rsid": "rs1800497",
      "gene": "ANKK1/DRD2 (Taq1A)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 1,
        "unique_cohort_count": 33,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ANKK1/DRD2 (Taq1A), domain=neuro_pharmacogenomics, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1360780|insights|C%2CC",
      "rsid": "rs1360780",
      "gene": "FKBP5 (stress response / HPA axis)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 2,
        "tier1_citation_count": 1,
        "unique_cohort_count": 2,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FKBP5 (stress response / HPA axis), domain=neuro_pharmacogenomics, citations=2, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1360780|insights|C%2CT",
      "rsid": "rs1360780",
      "gene": "FKBP5 (stress response / HPA axis)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 2,
        "tier1_citation_count": 1,
        "unique_cohort_count": 2,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FKBP5 (stress response / HPA axis), domain=neuro_pharmacogenomics, citations=2, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1360780|insights|T%2CT",
      "rsid": "rs1360780",
      "gene": "FKBP5 (stress response / HPA axis)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 2,
        "tier1_citation_count": 1,
        "unique_cohort_count": 2,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FKBP5 (stress response / HPA axis), domain=neuro_pharmacogenomics, citations=2, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1360780|genotypes|C%2CC",
      "rsid": "rs1360780",
      "gene": "FKBP5 (stress response / HPA axis)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 2,
        "tier1_citation_count": 1,
        "unique_cohort_count": 2,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FKBP5 (stress response / HPA axis), domain=neuro_pharmacogenomics, citations=2, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1360780|genotypes|C%2CT",
      "rsid": "rs1360780",
      "gene": "FKBP5 (stress response / HPA axis)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 2,
        "tier1_citation_count": 1,
        "unique_cohort_count": 2,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FKBP5 (stress response / HPA axis), domain=neuro_pharmacogenomics, citations=2, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1360780|genotypes|T%2CT",
      "rsid": "rs1360780",
      "gene": "FKBP5 (stress response / HPA axis)",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 2,
        "tier1_citation_count": 1,
        "unique_cohort_count": 2,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FKBP5 (stress response / HPA axis), domain=neuro_pharmacogenomics, citations=2, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1130233|insights|A%2CA",
      "rsid": "rs1130233",
      "gene": "AKT1",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 26,
        "tier1_citation_count": 0,
        "unique_cohort_count": 26,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=AKT1, domain=neuro_pharmacogenomics, citations=26, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1130233|insights|A%2CG",
      "rsid": "rs1130233",
      "gene": "AKT1",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 26,
        "tier1_citation_count": 0,
        "unique_cohort_count": 26,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=AKT1, domain=neuro_pharmacogenomics, citations=26, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1130233|insights|G%2CG",
      "rsid": "rs1130233",
      "gene": "AKT1",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 26,
        "tier1_citation_count": 0,
        "unique_cohort_count": 26,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=AKT1, domain=neuro_pharmacogenomics, citations=26, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs4244285|insights|G%2CG",
      "rsid": "rs4244285",
      "gene": "CYP2C19",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Pharmacogenomic"
      ],
      "strength": null,
      "conversation_context": "Authority-graded; medication-relevant",
      "conversation_priority": "Institutionally flagged",
      "feature_summary": {
        "citation_count": null,
        "tier1_citation_count": null,
        "unique_cohort_count": null,
        "effect_direction_agreement_pct": null,
        "total_cohort_n": null
      },
      "class_assignment_basis": "Pharmacogenomic per Pass 0 router and class grader consensus: gene=CYP2C19, domain=neuro_pharmacogenomics, citations=n/a, cohort_n=n/a.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs4244285|insights|G%2CA",
      "rsid": "rs4244285",
      "gene": "CYP2C19",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Pharmacogenomic"
      ],
      "strength": null,
      "conversation_context": "Authority-graded; medication-relevant",
      "conversation_priority": "Institutionally flagged",
      "feature_summary": {
        "citation_count": null,
        "tier1_citation_count": null,
        "unique_cohort_count": null,
        "effect_direction_agreement_pct": null,
        "total_cohort_n": null
      },
      "class_assignment_basis": "Pharmacogenomic per Pass 0 router and class grader consensus: gene=CYP2C19, domain=neuro_pharmacogenomics, citations=n/a, cohort_n=n/a.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs4244285|insights|A%2CA",
      "rsid": "rs4244285",
      "gene": "CYP2C19",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Pharmacogenomic"
      ],
      "strength": null,
      "conversation_context": "Authority-graded; medication-relevant",
      "conversation_priority": "Institutionally flagged",
      "feature_summary": {
        "citation_count": null,
        "tier1_citation_count": null,
        "unique_cohort_count": null,
        "effect_direction_agreement_pct": null,
        "total_cohort_n": null
      },
      "class_assignment_basis": "Pharmacogenomic per Pass 0 router and class grader consensus: gene=CYP2C19, domain=neuro_pharmacogenomics, citations=n/a, cohort_n=n/a.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1045642|insights|C%2CC",
      "rsid": "rs1045642",
      "gene": "ABCB1",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 29,
        "tier1_citation_count": 1,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ABCB1, domain=neuro_pharmacogenomics, citations=29, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1045642|insights|C%2CT",
      "rsid": "rs1045642",
      "gene": "ABCB1",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 29,
        "tier1_citation_count": 1,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ABCB1, domain=neuro_pharmacogenomics, citations=29, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "neuro_pharmacogenomics|rs1045642|insights|T%2CT",
      "rsid": "rs1045642",
      "gene": "ABCB1",
      "module_id": "neuro_pharmacogenomics",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 29,
        "tier1_citation_count": 1,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=ABCB1, domain=neuro_pharmacogenomics, citations=29, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs4646|genotypes|A%2CA",
      "rsid": "rs4646",
      "gene": "CYP19A1 / Aromatase",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 0,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP19A1 / Aromatase, domain=hormonal_androgen, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs4646|genotypes|A%2CC",
      "rsid": "rs4646",
      "gene": "CYP19A1 / Aromatase",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 0,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP19A1 / Aromatase, domain=hormonal_androgen, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs4646|genotypes|C%2CC",
      "rsid": "rs4646",
      "gene": "CYP19A1 / Aromatase",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 0,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP19A1 / Aromatase, domain=hormonal_androgen, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs523349|insights|C%2CC",
      "rsid": "rs523349",
      "gene": "SRD5A2 (5-alpha reductase type 2 / DHT conversion)",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 1,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SRD5A2 (5-alpha reductase type 2 / DHT conversion), domain=hormonal_androgen, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs523349|insights|C%2CG",
      "rsid": "rs523349",
      "gene": "SRD5A2 (5-alpha reductase type 2 / DHT conversion)",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 1,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SRD5A2 (5-alpha reductase type 2 / DHT conversion), domain=hormonal_androgen, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs523349|insights|G%2CG",
      "rsid": "rs523349",
      "gene": "SRD5A2 (5-alpha reductase type 2 / DHT conversion)",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 1,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SRD5A2 (5-alpha reductase type 2 / DHT conversion), domain=hormonal_androgen, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs523349|genotypes|G%2CG",
      "rsid": "rs523349",
      "gene": "SRD5A2 (5-alpha reductase type 2 / DHT conversion)",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 1,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SRD5A2 (5-alpha reductase type 2 / DHT conversion), domain=hormonal_androgen, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs523349|genotypes|G%2CC",
      "rsid": "rs523349",
      "gene": "SRD5A2 (5-alpha reductase type 2 / DHT conversion)",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 1,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SRD5A2 (5-alpha reductase type 2 / DHT conversion), domain=hormonal_androgen, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs523349|genotypes|C%2CC",
      "rsid": "rs523349",
      "gene": "SRD5A2 (5-alpha reductase type 2 / DHT conversion)",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 1,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SRD5A2 (5-alpha reductase type 2 / DHT conversion), domain=hormonal_androgen, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs743572|insights|T%2CT",
      "rsid": "rs743572",
      "gene": "CYP17A1 (17-alpha hydroxylase / steroid synthesis)",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 0,
        "unique_cohort_count": 33,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP17A1 (17-alpha hydroxylase / steroid synthesis), domain=hormonal_androgen, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs743572|insights|T%2CC",
      "rsid": "rs743572",
      "gene": "CYP17A1 (17-alpha hydroxylase / steroid synthesis)",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 0,
        "unique_cohort_count": 33,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP17A1 (17-alpha hydroxylase / steroid synthesis), domain=hormonal_androgen, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs743572|insights|C%2CC",
      "rsid": "rs743572",
      "gene": "CYP17A1 (17-alpha hydroxylase / steroid synthesis)",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 0,
        "unique_cohort_count": 33,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP17A1 (17-alpha hydroxylase / steroid synthesis), domain=hormonal_androgen, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs743572|genotypes|A%2CA",
      "rsid": "rs743572",
      "gene": "CYP17A1 (17-alpha hydroxylase / steroid synthesis)",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 0,
        "unique_cohort_count": 33,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP17A1 (17-alpha hydroxylase / steroid synthesis), domain=hormonal_androgen, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs743572|genotypes|A%2CC",
      "rsid": "rs743572",
      "gene": "CYP17A1 (17-alpha hydroxylase / steroid synthesis)",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 0,
        "unique_cohort_count": 33,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP17A1 (17-alpha hydroxylase / steroid synthesis), domain=hormonal_androgen, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs743572|genotypes|C%2CC",
      "rsid": "rs743572",
      "gene": "CYP17A1 (17-alpha hydroxylase / steroid synthesis)",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 0,
        "unique_cohort_count": 33,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP17A1 (17-alpha hydroxylase / steroid synthesis), domain=hormonal_androgen, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs2228570|insights|A%2CA",
      "rsid": "rs2228570",
      "gene": "VDR (Fok1 / Vitamin D receptor)",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 30,
        "tier1_citation_count": 0,
        "unique_cohort_count": 30,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=VDR (Fok1 / Vitamin D receptor), domain=hormonal_androgen, citations=30, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs2228570|insights|A%2CG",
      "rsid": "rs2228570",
      "gene": "VDR (Fok1 / Vitamin D receptor)",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 30,
        "tier1_citation_count": 0,
        "unique_cohort_count": 30,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=VDR (Fok1 / Vitamin D receptor), domain=hormonal_androgen, citations=30, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs2228570|insights|G%2CG",
      "rsid": "rs2228570",
      "gene": "VDR (Fok1 / Vitamin D receptor)",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 30,
        "tier1_citation_count": 0,
        "unique_cohort_count": 30,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=VDR (Fok1 / Vitamin D receptor), domain=hormonal_androgen, citations=30, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs2228570|genotypes|A%2CA",
      "rsid": "rs2228570",
      "gene": "VDR (Fok1 / Vitamin D receptor)",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 30,
        "tier1_citation_count": 0,
        "unique_cohort_count": 30,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=VDR (Fok1 / Vitamin D receptor), domain=hormonal_androgen, citations=30, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs2228570|genotypes|A%2CG",
      "rsid": "rs2228570",
      "gene": "VDR (Fok1 / Vitamin D receptor)",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 30,
        "tier1_citation_count": 0,
        "unique_cohort_count": 30,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=VDR (Fok1 / Vitamin D receptor), domain=hormonal_androgen, citations=30, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs2228570|genotypes|G%2CG",
      "rsid": "rs2228570",
      "gene": "VDR (Fok1 / Vitamin D receptor)",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 30,
        "tier1_citation_count": 0,
        "unique_cohort_count": 30,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=VDR (Fok1 / Vitamin D receptor), domain=hormonal_androgen, citations=30, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs700518|insights|A%2CA",
      "rsid": "rs700518",
      "gene": "CYP19A1",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 0,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP19A1, domain=hormonal_androgen, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs700518|insights|A%2CG",
      "rsid": "rs700518",
      "gene": "CYP19A1",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 0,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP19A1, domain=hormonal_androgen, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "hormonal_androgen|rs700518|insights|G%2CG",
      "rsid": "rs700518",
      "gene": "CYP19A1",
      "module_id": "hormonal_androgen",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 0,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CYP19A1, domain=hormonal_androgen, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2802292|insights|T%2CT",
      "rsid": "rs2802292",
      "gene": "FOXO3 (longevity-associated)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 36,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FOXO3 (longevity-associated), domain=longevity_telomere, citations=36, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2802292|insights|G%2CT",
      "rsid": "rs2802292",
      "gene": "FOXO3 (longevity-associated)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 36,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FOXO3 (longevity-associated), domain=longevity_telomere, citations=36, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2802292|insights|G%2CG",
      "rsid": "rs2802292",
      "gene": "FOXO3 (longevity-associated)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 36,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FOXO3 (longevity-associated), domain=longevity_telomere, citations=36, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2802292|genotypes|T%2CT",
      "rsid": "rs2802292",
      "gene": "FOXO3 (longevity-associated)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 36,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FOXO3 (longevity-associated), domain=longevity_telomere, citations=36, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2802292|genotypes|T%2CG",
      "rsid": "rs2802292",
      "gene": "FOXO3 (longevity-associated)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 36,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FOXO3 (longevity-associated), domain=longevity_telomere, citations=36, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2802292|genotypes|G%2CG",
      "rsid": "rs2802292",
      "gene": "FOXO3 (longevity-associated)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 36,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FOXO3 (longevity-associated), domain=longevity_telomere, citations=36, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs4946936|insights|A%2CA",
      "rsid": "rs4946936",
      "gene": "FOXO3 (longevity-associated)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 30,
        "tier1_citation_count": 1,
        "unique_cohort_count": 27,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FOXO3 (longevity-associated), domain=longevity_telomere, citations=30, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs4946936|insights|A%2CG",
      "rsid": "rs4946936",
      "gene": "FOXO3 (longevity-associated)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 30,
        "tier1_citation_count": 1,
        "unique_cohort_count": 27,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FOXO3 (longevity-associated), domain=longevity_telomere, citations=30, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs4946936|insights|G%2CG",
      "rsid": "rs4946936",
      "gene": "FOXO3 (longevity-associated)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 30,
        "tier1_citation_count": 1,
        "unique_cohort_count": 27,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FOXO3 (longevity-associated), domain=longevity_telomere, citations=30, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs4946936|genotypes|C%2CC",
      "rsid": "rs4946936",
      "gene": "FOXO3 (longevity-associated)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 30,
        "tier1_citation_count": 1,
        "unique_cohort_count": 27,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FOXO3 (longevity-associated), domain=longevity_telomere, citations=30, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs4946936|genotypes|C%2CT",
      "rsid": "rs4946936",
      "gene": "FOXO3 (longevity-associated)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 30,
        "tier1_citation_count": 1,
        "unique_cohort_count": 27,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FOXO3 (longevity-associated), domain=longevity_telomere, citations=30, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs4946936|genotypes|T%2CT",
      "rsid": "rs4946936",
      "gene": "FOXO3 (longevity-associated)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 30,
        "tier1_citation_count": 1,
        "unique_cohort_count": 27,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FOXO3 (longevity-associated), domain=longevity_telomere, citations=30, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2253310|insights|C%2CC",
      "rsid": "rs2253310",
      "gene": "FOXO3 (longevity-associated)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 40,
        "tier1_citation_count": 1,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FOXO3 (longevity-associated), domain=longevity_telomere, citations=40, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2253310|insights|C%2CT",
      "rsid": "rs2253310",
      "gene": "FOXO3 (longevity-associated)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 40,
        "tier1_citation_count": 1,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FOXO3 (longevity-associated), domain=longevity_telomere, citations=40, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2253310|insights|T%2CT",
      "rsid": "rs2253310",
      "gene": "FOXO3 (longevity-associated)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 40,
        "tier1_citation_count": 1,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FOXO3 (longevity-associated), domain=longevity_telomere, citations=40, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2253310|genotypes|C%2CC",
      "rsid": "rs2253310",
      "gene": "FOXO3 (longevity-associated)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 40,
        "tier1_citation_count": 1,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FOXO3 (longevity-associated), domain=longevity_telomere, citations=40, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2253310|genotypes|C%2CT",
      "rsid": "rs2253310",
      "gene": "FOXO3 (longevity-associated)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 40,
        "tier1_citation_count": 1,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FOXO3 (longevity-associated), domain=longevity_telomere, citations=40, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2253310|genotypes|T%2CT",
      "rsid": "rs2253310",
      "gene": "FOXO3 (longevity-associated)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 40,
        "tier1_citation_count": 1,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FOXO3 (longevity-associated), domain=longevity_telomere, citations=40, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs3758391|insights|C%2CC",
      "rsid": "rs3758391",
      "gene": "SIRT1 (sirtuin 1 / NAD+ metabolism)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 29,
        "tier1_citation_count": 0,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SIRT1 (sirtuin 1 / NAD+ metabolism), domain=longevity_telomere, citations=29, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs3758391|insights|C%2CT",
      "rsid": "rs3758391",
      "gene": "SIRT1 (sirtuin 1 / NAD+ metabolism)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 29,
        "tier1_citation_count": 0,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SIRT1 (sirtuin 1 / NAD+ metabolism), domain=longevity_telomere, citations=29, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs3758391|insights|T%2CT",
      "rsid": "rs3758391",
      "gene": "SIRT1 (sirtuin 1 / NAD+ metabolism)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 29,
        "tier1_citation_count": 0,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SIRT1 (sirtuin 1 / NAD+ metabolism), domain=longevity_telomere, citations=29, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs3758391|genotypes|T%2CT",
      "rsid": "rs3758391",
      "gene": "SIRT1 (sirtuin 1 / NAD+ metabolism)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 29,
        "tier1_citation_count": 0,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SIRT1 (sirtuin 1 / NAD+ metabolism), domain=longevity_telomere, citations=29, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs3758391|genotypes|T%2CC",
      "rsid": "rs3758391",
      "gene": "SIRT1 (sirtuin 1 / NAD+ metabolism)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 29,
        "tier1_citation_count": 0,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SIRT1 (sirtuin 1 / NAD+ metabolism), domain=longevity_telomere, citations=29, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs3758391|genotypes|C%2CC",
      "rsid": "rs3758391",
      "gene": "SIRT1 (sirtuin 1 / NAD+ metabolism)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 29,
        "tier1_citation_count": 0,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SIRT1 (sirtuin 1 / NAD+ metabolism), domain=longevity_telomere, citations=29, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2229765|insights|A%2CA",
      "rsid": "rs2229765",
      "gene": "IGF1R (insulin-like growth factor 1 receptor)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 28,
        "tier1_citation_count": 0,
        "unique_cohort_count": 28,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IGF1R (insulin-like growth factor 1 receptor), domain=longevity_telomere, citations=28, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2229765|insights|A%2CG",
      "rsid": "rs2229765",
      "gene": "IGF1R (insulin-like growth factor 1 receptor)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 28,
        "tier1_citation_count": 0,
        "unique_cohort_count": 28,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IGF1R (insulin-like growth factor 1 receptor), domain=longevity_telomere, citations=28, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2229765|insights|G%2CG",
      "rsid": "rs2229765",
      "gene": "IGF1R (insulin-like growth factor 1 receptor)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 28,
        "tier1_citation_count": 0,
        "unique_cohort_count": 28,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IGF1R (insulin-like growth factor 1 receptor), domain=longevity_telomere, citations=28, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2229765|genotypes|A%2CA",
      "rsid": "rs2229765",
      "gene": "IGF1R (insulin-like growth factor 1 receptor)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 28,
        "tier1_citation_count": 0,
        "unique_cohort_count": 28,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IGF1R (insulin-like growth factor 1 receptor), domain=longevity_telomere, citations=28, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2229765|genotypes|A%2CG",
      "rsid": "rs2229765",
      "gene": "IGF1R (insulin-like growth factor 1 receptor)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 28,
        "tier1_citation_count": 0,
        "unique_cohort_count": 28,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IGF1R (insulin-like growth factor 1 receptor), domain=longevity_telomere, citations=28, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2229765|genotypes|G%2CG",
      "rsid": "rs2229765",
      "gene": "IGF1R (insulin-like growth factor 1 receptor)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 28,
        "tier1_citation_count": 0,
        "unique_cohort_count": 28,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IGF1R (insulin-like growth factor 1 receptor), domain=longevity_telomere, citations=28, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2736100|insights|A%2CA",
      "rsid": "rs2736100",
      "gene": "TERT (telomerase reverse transcriptase)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Mixed evidence",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 88,
        "tier1_citation_count": 1,
        "unique_cohort_count": 39,
        "effect_direction_agreement_pct": 57,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TERT (telomerase reverse transcriptase), domain=longevity_telomere, citations=88, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2736100|insights|A%2CC",
      "rsid": "rs2736100",
      "gene": "TERT (telomerase reverse transcriptase)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Mixed evidence",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 88,
        "tier1_citation_count": 1,
        "unique_cohort_count": 39,
        "effect_direction_agreement_pct": 57,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TERT (telomerase reverse transcriptase), domain=longevity_telomere, citations=88, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2736100|insights|C%2CC",
      "rsid": "rs2736100",
      "gene": "TERT (telomerase reverse transcriptase)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Mixed evidence",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 88,
        "tier1_citation_count": 1,
        "unique_cohort_count": 39,
        "effect_direction_agreement_pct": 57,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TERT (telomerase reverse transcriptase), domain=longevity_telomere, citations=88, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2736100|genotypes|C%2CC",
      "rsid": "rs2736100",
      "gene": "TERT (telomerase reverse transcriptase)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Mixed evidence",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 88,
        "tier1_citation_count": 1,
        "unique_cohort_count": 39,
        "effect_direction_agreement_pct": 57,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TERT (telomerase reverse transcriptase), domain=longevity_telomere, citations=88, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2736100|genotypes|C%2CA",
      "rsid": "rs2736100",
      "gene": "TERT (telomerase reverse transcriptase)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Mixed evidence",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 88,
        "tier1_citation_count": 1,
        "unique_cohort_count": 39,
        "effect_direction_agreement_pct": 57,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TERT (telomerase reverse transcriptase), domain=longevity_telomere, citations=88, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs2736100|genotypes|A%2CA",
      "rsid": "rs2736100",
      "gene": "TERT (telomerase reverse transcriptase)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Mixed evidence",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 88,
        "tier1_citation_count": 1,
        "unique_cohort_count": 39,
        "effect_direction_agreement_pct": 57,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TERT (telomerase reverse transcriptase), domain=longevity_telomere, citations=88, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs10936599|insights|T%2CT",
      "rsid": "rs10936599",
      "gene": "TERC (telomerase RNA component)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 51,
        "tier1_citation_count": 1,
        "unique_cohort_count": 40,
        "effect_direction_agreement_pct": 59,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TERC (telomerase RNA component), domain=longevity_telomere, citations=51, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs10936599|insights|T%2CC",
      "rsid": "rs10936599",
      "gene": "TERC (telomerase RNA component)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 51,
        "tier1_citation_count": 1,
        "unique_cohort_count": 40,
        "effect_direction_agreement_pct": 59,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TERC (telomerase RNA component), domain=longevity_telomere, citations=51, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs10936599|insights|C%2CC",
      "rsid": "rs10936599",
      "gene": "TERC (telomerase RNA component)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 51,
        "tier1_citation_count": 1,
        "unique_cohort_count": 40,
        "effect_direction_agreement_pct": 59,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TERC (telomerase RNA component), domain=longevity_telomere, citations=51, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs10936599|genotypes|T%2CT",
      "rsid": "rs10936599",
      "gene": "TERC (telomerase RNA component)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 51,
        "tier1_citation_count": 1,
        "unique_cohort_count": 40,
        "effect_direction_agreement_pct": 59,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TERC (telomerase RNA component), domain=longevity_telomere, citations=51, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs10936599|genotypes|T%2CC",
      "rsid": "rs10936599",
      "gene": "TERC (telomerase RNA component)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 51,
        "tier1_citation_count": 1,
        "unique_cohort_count": 40,
        "effect_direction_agreement_pct": 59,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TERC (telomerase RNA component), domain=longevity_telomere, citations=51, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs10936599|genotypes|C%2CC",
      "rsid": "rs10936599",
      "gene": "TERC (telomerase RNA component)",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 51,
        "tier1_citation_count": 1,
        "unique_cohort_count": 40,
        "effect_direction_agreement_pct": 59,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TERC (telomerase RNA component), domain=longevity_telomere, citations=51, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs9536314|insights|C%2CC",
      "rsid": "rs9536314",
      "gene": "KL",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 1,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KL, domain=longevity_telomere, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs9536314|insights|C%2CG",
      "rsid": "rs9536314",
      "gene": "KL",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 1,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KL, domain=longevity_telomere, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs9536314|insights|G%2CG",
      "rsid": "rs9536314",
      "gene": "KL",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 1,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KL, domain=longevity_telomere, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs9536314|genotypes|T%2CT",
      "rsid": "rs9536314",
      "gene": "KL",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 1,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KL, domain=longevity_telomere, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs9536314|genotypes|T%2CG",
      "rsid": "rs9536314",
      "gene": "KL",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 1,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KL, domain=longevity_telomere, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs9536314|genotypes|G%2CG",
      "rsid": "rs9536314",
      "gene": "KL",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 1,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KL, domain=longevity_telomere, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs9527025|insights|C%2CC",
      "rsid": "rs9527025",
      "gene": "KL",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 29,
        "tier1_citation_count": 1,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KL, domain=longevity_telomere, citations=29, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs9527025|insights|C%2CT",
      "rsid": "rs9527025",
      "gene": "KL",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 29,
        "tier1_citation_count": 1,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KL, domain=longevity_telomere, citations=29, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs9527025|insights|T%2CT",
      "rsid": "rs9527025",
      "gene": "KL",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 29,
        "tier1_citation_count": 1,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KL, domain=longevity_telomere, citations=29, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs9527025|genotypes|A%2CA",
      "rsid": "rs9527025",
      "gene": "KL",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 29,
        "tier1_citation_count": 1,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KL, domain=longevity_telomere, citations=29, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs9527025|genotypes|A%2CG",
      "rsid": "rs9527025",
      "gene": "KL",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 29,
        "tier1_citation_count": 1,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KL, domain=longevity_telomere, citations=29, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs9527025|genotypes|G%2CG",
      "rsid": "rs9527025",
      "gene": "KL",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 29,
        "tier1_citation_count": 1,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KL, domain=longevity_telomere, citations=29, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs564481|insights|A%2CA",
      "rsid": "rs564481",
      "gene": "KL",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 26,
        "tier1_citation_count": 1,
        "unique_cohort_count": 26,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KL, domain=longevity_telomere, citations=26, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs564481|insights|A%2CG",
      "rsid": "rs564481",
      "gene": "KL",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 26,
        "tier1_citation_count": 1,
        "unique_cohort_count": 26,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KL, domain=longevity_telomere, citations=26, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs564481|insights|G%2CG",
      "rsid": "rs564481",
      "gene": "KL",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 26,
        "tier1_citation_count": 1,
        "unique_cohort_count": 26,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KL, domain=longevity_telomere, citations=26, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs564481|genotypes|T%2CT",
      "rsid": "rs564481",
      "gene": "KL",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 26,
        "tier1_citation_count": 1,
        "unique_cohort_count": 26,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KL, domain=longevity_telomere, citations=26, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs564481|genotypes|T%2CC",
      "rsid": "rs564481",
      "gene": "KL",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 26,
        "tier1_citation_count": 1,
        "unique_cohort_count": 26,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KL, domain=longevity_telomere, citations=26, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "longevity_telomere|rs564481|genotypes|C%2CC",
      "rsid": "rs564481",
      "gene": "KL",
      "module_id": "longevity_telomere",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 26,
        "tier1_citation_count": 1,
        "unique_cohort_count": 26,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KL, domain=longevity_telomere, citations=26, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1800795|insights|G%2CG",
      "rsid": "rs1800795",
      "gene": "IL6",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 7,
        "tier1_citation_count": 1,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IL6, domain=inflammation, citations=7, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1800795|insights|G%2CC",
      "rsid": "rs1800795",
      "gene": "IL6",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 7,
        "tier1_citation_count": 1,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IL6, domain=inflammation, citations=7, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1800795|insights|C%2CC",
      "rsid": "rs1800795",
      "gene": "IL6",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 7,
        "tier1_citation_count": 1,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IL6, domain=inflammation, citations=7, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1800795|genotypes|G%2CG",
      "rsid": "rs1800795",
      "gene": "IL6",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 7,
        "tier1_citation_count": 1,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IL6, domain=inflammation, citations=7, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1800795|genotypes|G%2CC",
      "rsid": "rs1800795",
      "gene": "IL6",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 7,
        "tier1_citation_count": 1,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IL6, domain=inflammation, citations=7, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1800795|genotypes|C%2CC",
      "rsid": "rs1800795",
      "gene": "IL6",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 7,
        "tier1_citation_count": 1,
        "unique_cohort_count": 5,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IL6, domain=inflammation, citations=7, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1800587|genotypes|C%2CC",
      "rsid": "rs1800587",
      "gene": "IL1A",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 0,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IL1A, domain=inflammation, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1800587|genotypes|C%2CT",
      "rsid": "rs1800587",
      "gene": "IL1A",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 0,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IL1A, domain=inflammation, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1800587|genotypes|T%2CT",
      "rsid": "rs1800587",
      "gene": "IL1A",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 0,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IL1A, domain=inflammation, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1143634|genotypes|C%2CC",
      "rsid": "rs1143634",
      "gene": "IL1B",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 0,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IL1B, domain=inflammation, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1143634|genotypes|C%2CT",
      "rsid": "rs1143634",
      "gene": "IL1B",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 0,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IL1B, domain=inflammation, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1143634|genotypes|T%2CT",
      "rsid": "rs1143634",
      "gene": "IL1B",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 0,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IL1B, domain=inflammation, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs16944|genotypes|A%2CA",
      "rsid": "rs16944",
      "gene": "IL1B",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 29,
        "tier1_citation_count": 0,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IL1B, domain=inflammation, citations=29, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs16944|genotypes|A%2CG",
      "rsid": "rs16944",
      "gene": "IL1B",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 29,
        "tier1_citation_count": 0,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IL1B, domain=inflammation, citations=29, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs16944|genotypes|G%2CG",
      "rsid": "rs16944",
      "gene": "IL1B",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 29,
        "tier1_citation_count": 0,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IL1B, domain=inflammation, citations=29, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1800896|insights|A%2CA",
      "rsid": "rs1800896",
      "gene": "IL10",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 26,
        "tier1_citation_count": 0,
        "unique_cohort_count": 26,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IL10, domain=inflammation, citations=26, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1800896|insights|A%2CG",
      "rsid": "rs1800896",
      "gene": "IL10",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 26,
        "tier1_citation_count": 0,
        "unique_cohort_count": 26,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IL10, domain=inflammation, citations=26, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1800896|insights|G%2CG",
      "rsid": "rs1800896",
      "gene": "IL10",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 26,
        "tier1_citation_count": 0,
        "unique_cohort_count": 26,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IL10, domain=inflammation, citations=26, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1800896|genotypes|A%2CA",
      "rsid": "rs1800896",
      "gene": "IL10",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 26,
        "tier1_citation_count": 0,
        "unique_cohort_count": 26,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IL10, domain=inflammation, citations=26, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1800896|genotypes|A%2CG",
      "rsid": "rs1800896",
      "gene": "IL10",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 26,
        "tier1_citation_count": 0,
        "unique_cohort_count": 26,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IL10, domain=inflammation, citations=26, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1800896|genotypes|G%2CG",
      "rsid": "rs1800896",
      "gene": "IL10",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 26,
        "tier1_citation_count": 0,
        "unique_cohort_count": 26,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IL10, domain=inflammation, citations=26, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1800629|insights|G%2CG",
      "rsid": "rs1800629",
      "gene": "TNF",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 0,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TNF, domain=inflammation, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1800629|insights|G%2CA",
      "rsid": "rs1800629",
      "gene": "TNF",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 0,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TNF, domain=inflammation, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1800629|insights|A%2CA",
      "rsid": "rs1800629",
      "gene": "TNF",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 0,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TNF, domain=inflammation, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1800629|genotypes|G%2CG",
      "rsid": "rs1800629",
      "gene": "TNF",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 0,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TNF, domain=inflammation, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1800629|genotypes|G%2CA",
      "rsid": "rs1800629",
      "gene": "TNF",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 0,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TNF, domain=inflammation, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1800629|genotypes|A%2CA",
      "rsid": "rs1800629",
      "gene": "TNF",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 0,
        "unique_cohort_count": 29,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TNF, domain=inflammation, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs4880|insights|C%2CC",
      "rsid": "rs4880",
      "gene": "SOD2 / MnSOD (Val16Ala, mitochondrial targeting)",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 30,
        "tier1_citation_count": 0,
        "unique_cohort_count": 30,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SOD2 / MnSOD (Val16Ala, mitochondrial targeting), domain=inflammation, citations=30, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs4880|insights|C%2CT",
      "rsid": "rs4880",
      "gene": "SOD2 / MnSOD (Val16Ala, mitochondrial targeting)",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 30,
        "tier1_citation_count": 0,
        "unique_cohort_count": 30,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SOD2 / MnSOD (Val16Ala, mitochondrial targeting), domain=inflammation, citations=30, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs4880|insights|T%2CT",
      "rsid": "rs4880",
      "gene": "SOD2 / MnSOD (Val16Ala, mitochondrial targeting)",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 30,
        "tier1_citation_count": 0,
        "unique_cohort_count": 30,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SOD2 / MnSOD (Val16Ala, mitochondrial targeting), domain=inflammation, citations=30, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs4880|genotypes|T%2CT",
      "rsid": "rs4880",
      "gene": "SOD2 / MnSOD (Val16Ala, mitochondrial targeting)",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 30,
        "tier1_citation_count": 0,
        "unique_cohort_count": 30,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SOD2 / MnSOD (Val16Ala, mitochondrial targeting), domain=inflammation, citations=30, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs4880|genotypes|T%2CC",
      "rsid": "rs4880",
      "gene": "SOD2 / MnSOD (Val16Ala, mitochondrial targeting)",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 30,
        "tier1_citation_count": 0,
        "unique_cohort_count": 30,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SOD2 / MnSOD (Val16Ala, mitochondrial targeting), domain=inflammation, citations=30, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs4880|genotypes|C%2CC",
      "rsid": "rs4880",
      "gene": "SOD2 / MnSOD (Val16Ala, mitochondrial targeting)",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 30,
        "tier1_citation_count": 0,
        "unique_cohort_count": 30,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=SOD2 / MnSOD (Val16Ala, mitochondrial targeting), domain=inflammation, citations=30, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1205|insights|C%2CC",
      "rsid": "rs1205",
      "gene": "CRP",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 1,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CRP, domain=inflammation, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1205|insights|C%2CT",
      "rsid": "rs1205",
      "gene": "CRP",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 1,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CRP, domain=inflammation, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1205|insights|T%2CT",
      "rsid": "rs1205",
      "gene": "CRP",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 1,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CRP, domain=inflammation, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1695|insights|A%2CA",
      "rsid": "rs1695",
      "gene": "GSTP1",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 0,
        "unique_cohort_count": 30,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=GSTP1, domain=inflammation, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1695|insights|A%2CG",
      "rsid": "rs1695",
      "gene": "GSTP1",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 0,
        "unique_cohort_count": 30,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=GSTP1, domain=inflammation, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs1695|insights|G%2CG",
      "rsid": "rs1695",
      "gene": "GSTP1",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 0,
        "unique_cohort_count": 30,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=GSTP1, domain=inflammation, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs4986790|insights|G%2CG",
      "rsid": "rs4986790",
      "gene": "TLR4",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 38,
        "tier1_citation_count": 0,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TLR4, domain=inflammation, citations=38, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs4986790|insights|G%2CA",
      "rsid": "rs4986790",
      "gene": "TLR4",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 38,
        "tier1_citation_count": 0,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TLR4, domain=inflammation, citations=38, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "inflammation|rs4986790|insights|A%2CA",
      "rsid": "rs4986790",
      "gene": "TLR4",
      "module_id": "inflammation",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 38,
        "tier1_citation_count": 0,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TLR4, domain=inflammation, citations=38, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1801133|insights|C%2CC",
      "rsid": "rs1801133",
      "gene": "MTHFR (C677T)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 79,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 91,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTHFR (C677T), domain=methylation_detox, citations=79, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1801133|insights|C%2CT",
      "rsid": "rs1801133",
      "gene": "MTHFR (C677T)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 79,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 91,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTHFR (C677T), domain=methylation_detox, citations=79, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1801133|insights|T%2CT",
      "rsid": "rs1801133",
      "gene": "MTHFR (C677T)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 79,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 91,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTHFR (C677T), domain=methylation_detox, citations=79, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1801133|genotypes|G%2CG",
      "rsid": "rs1801133",
      "gene": "MTHFR (C677T)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 79,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 91,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTHFR (C677T), domain=methylation_detox, citations=79, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1801133|genotypes|G%2CA",
      "rsid": "rs1801133",
      "gene": "MTHFR (C677T)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 79,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 91,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTHFR (C677T), domain=methylation_detox, citations=79, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1801133|genotypes|A%2CA",
      "rsid": "rs1801133",
      "gene": "MTHFR (C677T)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 79,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 91,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTHFR (C677T), domain=methylation_detox, citations=79, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1801131|insights|A%2CA",
      "rsid": "rs1801131",
      "gene": "MTHFR (A1298C)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 1,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTHFR (A1298C), domain=methylation_detox, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1801131|insights|A%2CC",
      "rsid": "rs1801131",
      "gene": "MTHFR (A1298C)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 1,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTHFR (A1298C), domain=methylation_detox, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1801131|insights|C%2CC",
      "rsid": "rs1801131",
      "gene": "MTHFR (A1298C)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 1,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTHFR (A1298C), domain=methylation_detox, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1801131|genotypes|T%2CT",
      "rsid": "rs1801131",
      "gene": "MTHFR (A1298C)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 1,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTHFR (A1298C), domain=methylation_detox, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1801131|genotypes|T%2CG",
      "rsid": "rs1801131",
      "gene": "MTHFR (A1298C)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 1,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTHFR (A1298C), domain=methylation_detox, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1801131|genotypes|G%2CG",
      "rsid": "rs1801131",
      "gene": "MTHFR (A1298C)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 1,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTHFR (A1298C), domain=methylation_detox, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1805087|insights|A%2CA",
      "rsid": "rs1805087",
      "gene": "MTR (methionine synthase A2756G)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 0,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTR (methionine synthase A2756G), domain=methylation_detox, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1805087|insights|A%2CG",
      "rsid": "rs1805087",
      "gene": "MTR (methionine synthase A2756G)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 0,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTR (methionine synthase A2756G), domain=methylation_detox, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1805087|insights|G%2CG",
      "rsid": "rs1805087",
      "gene": "MTR (methionine synthase A2756G)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 0,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTR (methionine synthase A2756G), domain=methylation_detox, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1805087|genotypes|A%2CA",
      "rsid": "rs1805087",
      "gene": "MTR (methionine synthase A2756G)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 0,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTR (methionine synthase A2756G), domain=methylation_detox, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1805087|genotypes|A%2CG",
      "rsid": "rs1805087",
      "gene": "MTR (methionine synthase A2756G)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 0,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTR (methionine synthase A2756G), domain=methylation_detox, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1805087|genotypes|G%2CG",
      "rsid": "rs1805087",
      "gene": "MTR (methionine synthase A2756G)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 34,
        "tier1_citation_count": 0,
        "unique_cohort_count": 34,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTR (methionine synthase A2756G), domain=methylation_detox, citations=34, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1801394|insights|A%2CA",
      "rsid": "rs1801394",
      "gene": "MTRR (methionine synthase reductase A66G)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 0,
        "unique_cohort_count": 33,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTRR (methionine synthase reductase A66G), domain=methylation_detox, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1801394|insights|A%2CG",
      "rsid": "rs1801394",
      "gene": "MTRR (methionine synthase reductase A66G)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 0,
        "unique_cohort_count": 33,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTRR (methionine synthase reductase A66G), domain=methylation_detox, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1801394|insights|G%2CG",
      "rsid": "rs1801394",
      "gene": "MTRR (methionine synthase reductase A66G)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 0,
        "unique_cohort_count": 33,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTRR (methionine synthase reductase A66G), domain=methylation_detox, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1801394|genotypes|A%2CA",
      "rsid": "rs1801394",
      "gene": "MTRR (methionine synthase reductase A66G)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 0,
        "unique_cohort_count": 33,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTRR (methionine synthase reductase A66G), domain=methylation_detox, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1801394|genotypes|A%2CG",
      "rsid": "rs1801394",
      "gene": "MTRR (methionine synthase reductase A66G)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 0,
        "unique_cohort_count": 33,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTRR (methionine synthase reductase A66G), domain=methylation_detox, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs1801394|genotypes|G%2CG",
      "rsid": "rs1801394",
      "gene": "MTRR (methionine synthase reductase A66G)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 0,
        "unique_cohort_count": 33,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTRR (methionine synthase reductase A66G), domain=methylation_detox, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs234706|insights|C%2CC",
      "rsid": "rs234706",
      "gene": "CBS (cystathionine beta-synthase)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 25,
        "tier1_citation_count": 0,
        "unique_cohort_count": 25,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CBS (cystathionine beta-synthase), domain=methylation_detox, citations=25, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs234706|insights|C%2CT",
      "rsid": "rs234706",
      "gene": "CBS (cystathionine beta-synthase)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 25,
        "tier1_citation_count": 0,
        "unique_cohort_count": 25,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CBS (cystathionine beta-synthase), domain=methylation_detox, citations=25, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs234706|insights|T%2CT",
      "rsid": "rs234706",
      "gene": "CBS (cystathionine beta-synthase)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 25,
        "tier1_citation_count": 0,
        "unique_cohort_count": 25,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CBS (cystathionine beta-synthase), domain=methylation_detox, citations=25, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs234706|genotypes|G%2CG",
      "rsid": "rs234706",
      "gene": "CBS (cystathionine beta-synthase)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 25,
        "tier1_citation_count": 0,
        "unique_cohort_count": 25,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CBS (cystathionine beta-synthase), domain=methylation_detox, citations=25, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs234706|genotypes|G%2CA",
      "rsid": "rs234706",
      "gene": "CBS (cystathionine beta-synthase)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 25,
        "tier1_citation_count": 0,
        "unique_cohort_count": 25,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CBS (cystathionine beta-synthase), domain=methylation_detox, citations=25, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs234706|genotypes|A%2CA",
      "rsid": "rs234706",
      "gene": "CBS (cystathionine beta-synthase)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 25,
        "tier1_citation_count": 0,
        "unique_cohort_count": 25,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=CBS (cystathionine beta-synthase), domain=methylation_detox, citations=25, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs3733890|insights|G%2CG",
      "rsid": "rs3733890",
      "gene": "BHMT (betaine-homocysteine methyltransferase)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=BHMT (betaine-homocysteine methyltransferase), domain=methylation_detox, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs3733890|insights|G%2CA",
      "rsid": "rs3733890",
      "gene": "BHMT (betaine-homocysteine methyltransferase)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=BHMT (betaine-homocysteine methyltransferase), domain=methylation_detox, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs3733890|insights|A%2CA",
      "rsid": "rs3733890",
      "gene": "BHMT (betaine-homocysteine methyltransferase)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=BHMT (betaine-homocysteine methyltransferase), domain=methylation_detox, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs3733890|genotypes|A%2CA",
      "rsid": "rs3733890",
      "gene": "BHMT (betaine-homocysteine methyltransferase)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=BHMT (betaine-homocysteine methyltransferase), domain=methylation_detox, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs3733890|genotypes|A%2CG",
      "rsid": "rs3733890",
      "gene": "BHMT (betaine-homocysteine methyltransferase)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=BHMT (betaine-homocysteine methyltransferase), domain=methylation_detox, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs3733890|genotypes|G%2CG",
      "rsid": "rs3733890",
      "gene": "BHMT (betaine-homocysteine methyltransferase)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 100,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=BHMT (betaine-homocysteine methyltransferase), domain=methylation_detox, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs601338|insights|G%2CG",
      "rsid": "rs601338",
      "gene": "FUT2 (secretor status / B12 absorption / gut microbiome)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 200,
        "tier1_citation_count": 1,
        "unique_cohort_count": 37,
        "effect_direction_agreement_pct": 88,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FUT2 (secretor status / B12 absorption / gut microbiome), domain=methylation_detox, citations=200, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs601338|insights|G%2CA",
      "rsid": "rs601338",
      "gene": "FUT2 (secretor status / B12 absorption / gut microbiome)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 200,
        "tier1_citation_count": 1,
        "unique_cohort_count": 37,
        "effect_direction_agreement_pct": 88,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FUT2 (secretor status / B12 absorption / gut microbiome), domain=methylation_detox, citations=200, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs601338|insights|A%2CA",
      "rsid": "rs601338",
      "gene": "FUT2 (secretor status / B12 absorption / gut microbiome)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 200,
        "tier1_citation_count": 1,
        "unique_cohort_count": 37,
        "effect_direction_agreement_pct": 88,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FUT2 (secretor status / B12 absorption / gut microbiome), domain=methylation_detox, citations=200, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs601338|genotypes|G%2CG",
      "rsid": "rs601338",
      "gene": "FUT2 (secretor status / B12 absorption / gut microbiome)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 200,
        "tier1_citation_count": 1,
        "unique_cohort_count": 37,
        "effect_direction_agreement_pct": 88,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FUT2 (secretor status / B12 absorption / gut microbiome), domain=methylation_detox, citations=200, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs601338|genotypes|G%2CA",
      "rsid": "rs601338",
      "gene": "FUT2 (secretor status / B12 absorption / gut microbiome)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 200,
        "tier1_citation_count": 1,
        "unique_cohort_count": 37,
        "effect_direction_agreement_pct": 88,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FUT2 (secretor status / B12 absorption / gut microbiome), domain=methylation_detox, citations=200, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "methylation_detox|rs601338|genotypes|A%2CA",
      "rsid": "rs601338",
      "gene": "FUT2 (secretor status / B12 absorption / gut microbiome)",
      "module_id": "methylation_detox",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 200,
        "tier1_citation_count": 1,
        "unique_cohort_count": 37,
        "effect_direction_agreement_pct": 88,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FUT2 (secretor status / B12 absorption / gut microbiome), domain=methylation_detox, citations=200, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs7903146|insights|C%2CC",
      "rsid": "rs7903146",
      "gene": "TCF7L2",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 376,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 84,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TCF7L2, domain=metabolic_diabetes, citations=376, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs7903146|insights|C%2CT",
      "rsid": "rs7903146",
      "gene": "TCF7L2",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 376,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 84,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TCF7L2, domain=metabolic_diabetes, citations=376, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs7903146|insights|T%2CT",
      "rsid": "rs7903146",
      "gene": "TCF7L2",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 376,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 84,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TCF7L2, domain=metabolic_diabetes, citations=376, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs7903146|genotypes|C%2CC",
      "rsid": "rs7903146",
      "gene": "TCF7L2",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 376,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 84,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TCF7L2, domain=metabolic_diabetes, citations=376, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs7903146|genotypes|C%2CT",
      "rsid": "rs7903146",
      "gene": "TCF7L2",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 376,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 84,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TCF7L2, domain=metabolic_diabetes, citations=376, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs7903146|genotypes|T%2CT",
      "rsid": "rs7903146",
      "gene": "TCF7L2",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 376,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 84,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=TCF7L2, domain=metabolic_diabetes, citations=376, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs5219|insights|C%2CC",
      "rsid": "rs5219",
      "gene": "KCNJ11 (Kir6.2 / KATP channel E23K)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 54,
        "tier1_citation_count": 1,
        "unique_cohort_count": 37,
        "effect_direction_agreement_pct": 55,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KCNJ11 (Kir6.2 / KATP channel E23K), domain=metabolic_diabetes, citations=54, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs5219|insights|C%2CT",
      "rsid": "rs5219",
      "gene": "KCNJ11 (Kir6.2 / KATP channel E23K)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 54,
        "tier1_citation_count": 1,
        "unique_cohort_count": 37,
        "effect_direction_agreement_pct": 55,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KCNJ11 (Kir6.2 / KATP channel E23K), domain=metabolic_diabetes, citations=54, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs5219|insights|T%2CT",
      "rsid": "rs5219",
      "gene": "KCNJ11 (Kir6.2 / KATP channel E23K)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 54,
        "tier1_citation_count": 1,
        "unique_cohort_count": 37,
        "effect_direction_agreement_pct": 55,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KCNJ11 (Kir6.2 / KATP channel E23K), domain=metabolic_diabetes, citations=54, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs5219|genotypes|A%2CA",
      "rsid": "rs5219",
      "gene": "KCNJ11 (Kir6.2 / KATP channel E23K)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 54,
        "tier1_citation_count": 1,
        "unique_cohort_count": 37,
        "effect_direction_agreement_pct": 55,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KCNJ11 (Kir6.2 / KATP channel E23K), domain=metabolic_diabetes, citations=54, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs5219|genotypes|A%2CG",
      "rsid": "rs5219",
      "gene": "KCNJ11 (Kir6.2 / KATP channel E23K)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 54,
        "tier1_citation_count": 1,
        "unique_cohort_count": 37,
        "effect_direction_agreement_pct": 55,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KCNJ11 (Kir6.2 / KATP channel E23K), domain=metabolic_diabetes, citations=54, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs5219|genotypes|G%2CG",
      "rsid": "rs5219",
      "gene": "KCNJ11 (Kir6.2 / KATP channel E23K)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 54,
        "tier1_citation_count": 1,
        "unique_cohort_count": 37,
        "effect_direction_agreement_pct": 55,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=KCNJ11 (Kir6.2 / KATP channel E23K), domain=metabolic_diabetes, citations=54, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs4402960|insights|G%2CG",
      "rsid": "rs4402960",
      "gene": "IGF2BP2",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 44,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 82,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IGF2BP2, domain=metabolic_diabetes, citations=44, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs4402960|insights|G%2CT",
      "rsid": "rs4402960",
      "gene": "IGF2BP2",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 44,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 82,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IGF2BP2, domain=metabolic_diabetes, citations=44, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs4402960|insights|T%2CT",
      "rsid": "rs4402960",
      "gene": "IGF2BP2",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 44,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 82,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IGF2BP2, domain=metabolic_diabetes, citations=44, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs4402960|genotypes|T%2CT",
      "rsid": "rs4402960",
      "gene": "IGF2BP2",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 44,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 82,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IGF2BP2, domain=metabolic_diabetes, citations=44, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs4402960|genotypes|T%2CG",
      "rsid": "rs4402960",
      "gene": "IGF2BP2",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 44,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 82,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IGF2BP2, domain=metabolic_diabetes, citations=44, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs4402960|genotypes|G%2CG",
      "rsid": "rs4402960",
      "gene": "IGF2BP2",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 44,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 82,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=IGF2BP2, domain=metabolic_diabetes, citations=44, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs9939609|insights|T%2CT",
      "rsid": "rs9939609",
      "gene": "FTO (fat mass and obesity associated)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 43,
        "tier1_citation_count": 1,
        "unique_cohort_count": 35,
        "effect_direction_agreement_pct": 62,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FTO (fat mass and obesity associated), domain=metabolic_diabetes, citations=43, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs9939609|insights|A%2CT",
      "rsid": "rs9939609",
      "gene": "FTO (fat mass and obesity associated)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 43,
        "tier1_citation_count": 1,
        "unique_cohort_count": 35,
        "effect_direction_agreement_pct": 62,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FTO (fat mass and obesity associated), domain=metabolic_diabetes, citations=43, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs9939609|insights|A%2CA",
      "rsid": "rs9939609",
      "gene": "FTO (fat mass and obesity associated)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 43,
        "tier1_citation_count": 1,
        "unique_cohort_count": 35,
        "effect_direction_agreement_pct": 62,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FTO (fat mass and obesity associated), domain=metabolic_diabetes, citations=43, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs9939609|genotypes|T%2CT",
      "rsid": "rs9939609",
      "gene": "FTO (fat mass and obesity associated)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 43,
        "tier1_citation_count": 1,
        "unique_cohort_count": 35,
        "effect_direction_agreement_pct": 62,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FTO (fat mass and obesity associated), domain=metabolic_diabetes, citations=43, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs9939609|genotypes|T%2CA",
      "rsid": "rs9939609",
      "gene": "FTO (fat mass and obesity associated)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 43,
        "tier1_citation_count": 1,
        "unique_cohort_count": 35,
        "effect_direction_agreement_pct": 62,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FTO (fat mass and obesity associated), domain=metabolic_diabetes, citations=43, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs9939609|genotypes|A%2CA",
      "rsid": "rs9939609",
      "gene": "FTO (fat mass and obesity associated)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": null,
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 43,
        "tier1_citation_count": 1,
        "unique_cohort_count": 35,
        "effect_direction_agreement_pct": 62,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=FTO (fat mass and obesity associated), domain=metabolic_diabetes, citations=43, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "risk-ambiguous-thresholds",
        "risk-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs1801282|insights|C%2CC",
      "rsid": "rs1801282",
      "gene": "PPARG (Pro12Ala)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 100,
        "tier1_citation_count": 1,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 84,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=PPARG (Pro12Ala), domain=metabolic_diabetes, citations=100, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs1801282|insights|C%2CG",
      "rsid": "rs1801282",
      "gene": "PPARG (Pro12Ala)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 100,
        "tier1_citation_count": 1,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 84,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=PPARG (Pro12Ala), domain=metabolic_diabetes, citations=100, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs1801282|insights|G%2CG",
      "rsid": "rs1801282",
      "gene": "PPARG (Pro12Ala)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 100,
        "tier1_citation_count": 1,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 84,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=PPARG (Pro12Ala), domain=metabolic_diabetes, citations=100, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs1801282|genotypes|G%2CG",
      "rsid": "rs1801282",
      "gene": "PPARG (Pro12Ala)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 100,
        "tier1_citation_count": 1,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 84,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=PPARG (Pro12Ala), domain=metabolic_diabetes, citations=100, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs1801282|genotypes|G%2CC",
      "rsid": "rs1801282",
      "gene": "PPARG (Pro12Ala)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 100,
        "tier1_citation_count": 1,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 84,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=PPARG (Pro12Ala), domain=metabolic_diabetes, citations=100, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs1801282|genotypes|C%2CC",
      "rsid": "rs1801282",
      "gene": "PPARG (Pro12Ala)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 100,
        "tier1_citation_count": 1,
        "unique_cohort_count": 38,
        "effect_direction_agreement_pct": 84,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=PPARG (Pro12Ala), domain=metabolic_diabetes, citations=100, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs10830963|insights|C%2CC",
      "rsid": "rs10830963",
      "gene": "MTNR1B (melatonin receptor 1B)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 201,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 86,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTNR1B (melatonin receptor 1B), domain=metabolic_diabetes, citations=201, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs10830963|insights|C%2CG",
      "rsid": "rs10830963",
      "gene": "MTNR1B (melatonin receptor 1B)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 201,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 86,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTNR1B (melatonin receptor 1B), domain=metabolic_diabetes, citations=201, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs10830963|insights|G%2CG",
      "rsid": "rs10830963",
      "gene": "MTNR1B (melatonin receptor 1B)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 201,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 86,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTNR1B (melatonin receptor 1B), domain=metabolic_diabetes, citations=201, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs10830963|genotypes|C%2CC",
      "rsid": "rs10830963",
      "gene": "MTNR1B (melatonin receptor 1B)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 201,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 86,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTNR1B (melatonin receptor 1B), domain=metabolic_diabetes, citations=201, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs10830963|genotypes|C%2CG",
      "rsid": "rs10830963",
      "gene": "MTNR1B (melatonin receptor 1B)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 201,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 86,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTNR1B (melatonin receptor 1B), domain=metabolic_diabetes, citations=201, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs10830963|genotypes|G%2CG",
      "rsid": "rs10830963",
      "gene": "MTNR1B (melatonin receptor 1B)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 201,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 86,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=MTNR1B (melatonin receptor 1B), domain=metabolic_diabetes, citations=201, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs4988235|insights|T%2CT",
      "rsid": "rs4988235",
      "gene": "LCT / MCM6 (lactase persistence)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 100,
        "tier1_citation_count": 1,
        "unique_cohort_count": 39,
        "effect_direction_agreement_pct": 98,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=LCT / MCM6 (lactase persistence), domain=metabolic_diabetes, citations=100, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs4988235|insights|C%2CT",
      "rsid": "rs4988235",
      "gene": "LCT / MCM6 (lactase persistence)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 100,
        "tier1_citation_count": 1,
        "unique_cohort_count": 39,
        "effect_direction_agreement_pct": 98,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=LCT / MCM6 (lactase persistence), domain=metabolic_diabetes, citations=100, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs4988235|insights|C%2CC",
      "rsid": "rs4988235",
      "gene": "LCT / MCM6 (lactase persistence)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 100,
        "tier1_citation_count": 1,
        "unique_cohort_count": 39,
        "effect_direction_agreement_pct": 98,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=LCT / MCM6 (lactase persistence), domain=metabolic_diabetes, citations=100, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs4988235|genotypes|T%2CT",
      "rsid": "rs4988235",
      "gene": "LCT / MCM6 (lactase persistence)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 100,
        "tier1_citation_count": 1,
        "unique_cohort_count": 39,
        "effect_direction_agreement_pct": 98,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=LCT / MCM6 (lactase persistence), domain=metabolic_diabetes, citations=100, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs4988235|genotypes|T%2CC",
      "rsid": "rs4988235",
      "gene": "LCT / MCM6 (lactase persistence)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 100,
        "tier1_citation_count": 1,
        "unique_cohort_count": 39,
        "effect_direction_agreement_pct": 98,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=LCT / MCM6 (lactase persistence), domain=metabolic_diabetes, citations=100, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "metabolic_diabetes|rs4988235|genotypes|C%2CC",
      "rsid": "rs4988235",
      "gene": "LCT / MCM6 (lactase persistence)",
      "module_id": "metabolic_diabetes",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 100,
        "tier1_citation_count": 1,
        "unique_cohort_count": 39,
        "effect_direction_agreement_pct": 98,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=LCT / MCM6 (lactase persistence), domain=metabolic_diabetes, citations=100, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "physical_performance|rs1815739|insights|C%2CC",
      "rsid": "rs1815739",
      "gene": "ACTN3 (R577X)",
      "module_id": "physical_performance",
      "variant_class": [
        "Trait/lifestyle"
      ],
      "strength": "Consistent",
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 41,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 75,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Trait/lifestyle per Pass 0 router and class grader consensus: gene=ACTN3 (R577X), domain=physical_performance, citations=41, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "trait-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "physical_performance|rs1815739|insights|C%2CT",
      "rsid": "rs1815739",
      "gene": "ACTN3 (R577X)",
      "module_id": "physical_performance",
      "variant_class": [
        "Trait/lifestyle"
      ],
      "strength": "Consistent",
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 41,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 75,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Trait/lifestyle per Pass 0 router and class grader consensus: gene=ACTN3 (R577X), domain=physical_performance, citations=41, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "trait-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "physical_performance|rs1815739|insights|T%2CT",
      "rsid": "rs1815739",
      "gene": "ACTN3 (R577X)",
      "module_id": "physical_performance",
      "variant_class": [
        "Trait/lifestyle"
      ],
      "strength": "Consistent",
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 41,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 75,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Trait/lifestyle per Pass 0 router and class grader consensus: gene=ACTN3 (R577X), domain=physical_performance, citations=41, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "trait-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "physical_performance|rs1815739|genotypes|C%2CC",
      "rsid": "rs1815739",
      "gene": "ACTN3 (R577X)",
      "module_id": "physical_performance",
      "variant_class": [
        "Trait/lifestyle"
      ],
      "strength": "Consistent",
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 41,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 75,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Trait/lifestyle per Pass 0 router and class grader consensus: gene=ACTN3 (R577X), domain=physical_performance, citations=41, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "trait-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "physical_performance|rs1815739|genotypes|C%2CT",
      "rsid": "rs1815739",
      "gene": "ACTN3 (R577X)",
      "module_id": "physical_performance",
      "variant_class": [
        "Trait/lifestyle"
      ],
      "strength": "Consistent",
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 41,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 75,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Trait/lifestyle per Pass 0 router and class grader consensus: gene=ACTN3 (R577X), domain=physical_performance, citations=41, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "trait-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "physical_performance|rs1815739|genotypes|T%2CT",
      "rsid": "rs1815739",
      "gene": "ACTN3 (R577X)",
      "module_id": "physical_performance",
      "variant_class": [
        "Trait/lifestyle"
      ],
      "strength": "Consistent",
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 41,
        "tier1_citation_count": 1,
        "unique_cohort_count": 36,
        "effect_direction_agreement_pct": 75,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Trait/lifestyle per Pass 0 router and class grader consensus: gene=ACTN3 (R577X), domain=physical_performance, citations=41, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "trait-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "physical_performance|rs12722|genotypes|C%2CC",
      "rsid": "rs12722",
      "gene": "COL5A1 (collagen type V alpha 1)",
      "module_id": "physical_performance",
      "variant_class": [
        "Trait/lifestyle"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 0,
        "unique_cohort_count": 33,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Trait/lifestyle per Pass 0 router and class grader consensus: gene=COL5A1 (collagen type V alpha 1), domain=physical_performance, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "trait-ambiguous-thresholds",
        "trait-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "physical_performance|rs12722|genotypes|C%2CT",
      "rsid": "rs12722",
      "gene": "COL5A1 (collagen type V alpha 1)",
      "module_id": "physical_performance",
      "variant_class": [
        "Trait/lifestyle"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 0,
        "unique_cohort_count": 33,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Trait/lifestyle per Pass 0 router and class grader consensus: gene=COL5A1 (collagen type V alpha 1), domain=physical_performance, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "trait-ambiguous-thresholds",
        "trait-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "physical_performance|rs12722|genotypes|T%2CT",
      "rsid": "rs12722",
      "gene": "COL5A1 (collagen type V alpha 1)",
      "module_id": "physical_performance",
      "variant_class": [
        "Trait/lifestyle"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 33,
        "tier1_citation_count": 0,
        "unique_cohort_count": 33,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Trait/lifestyle per Pass 0 router and class grader consensus: gene=COL5A1 (collagen type V alpha 1), domain=physical_performance, citations=33, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "trait-ambiguous-thresholds",
        "trait-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "physical_performance|rs8192678|insights|G%2CG",
      "rsid": "rs8192678",
      "gene": "PPARGC1A / PGC-1α (Gly482Ser)",
      "module_id": "physical_performance",
      "variant_class": [
        "Trait/lifestyle"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Trait/lifestyle per Pass 0 router and class grader consensus: gene=PPARGC1A / PGC-1α (Gly482Ser), domain=physical_performance, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "trait-ambiguous-thresholds",
        "trait-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "physical_performance|rs8192678|insights|G%2CA",
      "rsid": "rs8192678",
      "gene": "PPARGC1A / PGC-1α (Gly482Ser)",
      "module_id": "physical_performance",
      "variant_class": [
        "Trait/lifestyle"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Trait/lifestyle per Pass 0 router and class grader consensus: gene=PPARGC1A / PGC-1α (Gly482Ser), domain=physical_performance, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "trait-ambiguous-thresholds",
        "trait-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "physical_performance|rs8192678|insights|A%2CA",
      "rsid": "rs8192678",
      "gene": "PPARGC1A / PGC-1α (Gly482Ser)",
      "module_id": "physical_performance",
      "variant_class": [
        "Trait/lifestyle"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Trait/lifestyle per Pass 0 router and class grader consensus: gene=PPARGC1A / PGC-1α (Gly482Ser), domain=physical_performance, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "trait-ambiguous-thresholds",
        "trait-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "physical_performance|rs8192678|genotypes|G%2CG",
      "rsid": "rs8192678",
      "gene": "PPARGC1A / PGC-1α (Gly482Ser)",
      "module_id": "physical_performance",
      "variant_class": [
        "Trait/lifestyle"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Trait/lifestyle per Pass 0 router and class grader consensus: gene=PPARGC1A / PGC-1α (Gly482Ser), domain=physical_performance, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "trait-ambiguous-thresholds",
        "trait-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "physical_performance|rs8192678|genotypes|G%2CA",
      "rsid": "rs8192678",
      "gene": "PPARGC1A / PGC-1α (Gly482Ser)",
      "module_id": "physical_performance",
      "variant_class": [
        "Trait/lifestyle"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Trait/lifestyle per Pass 0 router and class grader consensus: gene=PPARGC1A / PGC-1α (Gly482Ser), domain=physical_performance, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "trait-ambiguous-thresholds",
        "trait-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "physical_performance|rs8192678|genotypes|A%2CA",
      "rsid": "rs8192678",
      "gene": "PPARGC1A / PGC-1α (Gly482Ser)",
      "module_id": "physical_performance",
      "variant_class": [
        "Trait/lifestyle"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 31,
        "tier1_citation_count": 0,
        "unique_cohort_count": 31,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Trait/lifestyle per Pass 0 router and class grader consensus: gene=PPARGC1A / PGC-1α (Gly482Ser), domain=physical_performance, citations=31, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "trait-ambiguous-thresholds",
        "trait-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "physical_performance|rs1799752|insights|I%2CI",
      "rsid": "rs1799752",
      "gene": "ACE",
      "module_id": "physical_performance",
      "variant_class": [
        "Trait/lifestyle"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 1,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Trait/lifestyle per Pass 0 router and class grader consensus: gene=ACE, domain=physical_performance, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "trait-ambiguous-thresholds",
        "trait-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "physical_performance|rs1799752|insights|I%2CD",
      "rsid": "rs1799752",
      "gene": "ACE",
      "module_id": "physical_performance",
      "variant_class": [
        "Trait/lifestyle"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 1,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Trait/lifestyle per Pass 0 router and class grader consensus: gene=ACE, domain=physical_performance, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "trait-ambiguous-thresholds",
        "trait-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "physical_performance|rs1799752|insights|D%2CD",
      "rsid": "rs1799752",
      "gene": "ACE",
      "module_id": "physical_performance",
      "variant_class": [
        "Trait/lifestyle"
      ],
      "strength": null,
      "conversation_context": "Educational; no authority framework",
      "conversation_priority": "Evidence insufficient to characterize",
      "feature_summary": {
        "citation_count": 32,
        "tier1_citation_count": 1,
        "unique_cohort_count": 32,
        "effect_direction_agreement_pct": 0,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Trait/lifestyle per Pass 0 router and class grader consensus: gene=ACE, domain=physical_performance, citations=32, cohort_n=0.",
      "override_flag": true,
      "override_trigger_codes": [
        "trait-ambiguous-thresholds",
        "trait-low-direction-extraction"
      ],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "apoc1_haplotype|rs4420638|insights|A%2CA",
      "rsid": "rs4420638",
      "gene": "APOC1 (H2 haplotype proxy)",
      "module_id": "apoc1_haplotype",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 226,
        "tier1_citation_count": 1,
        "unique_cohort_count": 10,
        "effect_direction_agreement_pct": 86,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=APOC1 (H2 haplotype proxy), domain=apoc1_haplotype, citations=226, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "apoc1_haplotype|rs4420638|insights|A%2CG",
      "rsid": "rs4420638",
      "gene": "APOC1 (H2 haplotype proxy)",
      "module_id": "apoc1_haplotype",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 226,
        "tier1_citation_count": 1,
        "unique_cohort_count": 10,
        "effect_direction_agreement_pct": 86,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=APOC1 (H2 haplotype proxy), domain=apoc1_haplotype, citations=226, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "apoc1_haplotype|rs4420638|insights|G%2CG",
      "rsid": "rs4420638",
      "gene": "APOC1 (H2 haplotype proxy)",
      "module_id": "apoc1_haplotype",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 226,
        "tier1_citation_count": 1,
        "unique_cohort_count": 10,
        "effect_direction_agreement_pct": 86,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=APOC1 (H2 haplotype proxy), domain=apoc1_haplotype, citations=226, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "apoc1_haplotype|rs4420638|genotypes|A%2CA",
      "rsid": "rs4420638",
      "gene": "APOC1 (H2 haplotype proxy)",
      "module_id": "apoc1_haplotype",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 226,
        "tier1_citation_count": 1,
        "unique_cohort_count": 10,
        "effect_direction_agreement_pct": 86,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=APOC1 (H2 haplotype proxy), domain=apoc1_haplotype, citations=226, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "apoc1_haplotype|rs4420638|genotypes|A%2CG",
      "rsid": "rs4420638",
      "gene": "APOC1 (H2 haplotype proxy)",
      "module_id": "apoc1_haplotype",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 226,
        "tier1_citation_count": 1,
        "unique_cohort_count": 10,
        "effect_direction_agreement_pct": 86,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=APOC1 (H2 haplotype proxy), domain=apoc1_haplotype, citations=226, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    },
    {
      "catalog_entry_id": "apoc1_haplotype|rs4420638|genotypes|G%2CG",
      "rsid": "rs4420638",
      "gene": "APOC1 (H2 haplotype proxy)",
      "module_id": "apoc1_haplotype",
      "variant_class": [
        "Risk-modifier"
      ],
      "strength": "Consistent",
      "conversation_context": "Guideline-referenced; physician-discussion-common",
      "conversation_priority": "Background context",
      "feature_summary": {
        "citation_count": 226,
        "tier1_citation_count": 1,
        "unique_cohort_count": 10,
        "effect_direction_agreement_pct": 86,
        "total_cohort_n": 0
      },
      "class_assignment_basis": "Risk-modifier per Pass 0 router and class grader consensus: gene=APOC1 (H2 haplotype proxy), domain=apoc1_haplotype, citations=226, cohort_n=0.",
      "override_flag": false,
      "override_trigger_codes": [],
      "last_graded_at": "2026-05-28",
      "evidence_revision_id": "2026-05-27"
    }
  ]
}
