# Varia Editorial Event Log

**Schema version:** 1.2
**Format:** chronological append-only; newest entries at top of post-schema-header section.
**Per VEGS § 10:** every detector alert and editor response logged here.
**Sprint 76 (2026-08-18) forward fields:** Closed at; Reclassification. Historical entries keep the 1.1 field set. Detector outage days start tracking 2026-08-18 as a metrics-level field, not a per-entry rewrite.

Entry format:

```
## YYYY-MM-DDTHH:MM:SSZ | <detector-source> | <catalog-entry-id>

**Entry ID:** ...
**Alert class:** pathogenic | standard
**Change summary:** ...
**Detector trigger:** ...
**Editor action:** PENDING | <action taken with date>
**Action rationale:** PENDING | <link to commit / decision rationale>
**SLA status:** open <N> days | closed <N> days within SLA | closed <N> days SLA missed
**Closed at:** N/A | YYYY-MM-DDTHH:MM:SSZ
**Reclassification:** none | <from> -> <to> (<authority>)
**Auto-downgrade applied:** false | true at YYYY-MM-DDTHH:MM:SSZ
**Auto-downgrade reversed:** N/A | YYYY-MM-DDTHH:MM:SSZ
**Authority source:** <source-id>
**Rule invoked:** N/A | <vegs-rule>
**Override resolution status:** N/A | pending | resolved | reversed
**Alert resolution criteria:** authority_data_reviewed=true|false; schema_updates_applied=true|false; rationale_logged=true|false; historical_interpretations_archived_if_applicable=true|false
```


**Archived entries:** May 2026 structured entries and VEAS pipeline v0.2 bulk events moved to `state-archive/editorial-event-log-archive-2026-Q2.md` (2026-06-10 log rotation). Every line preserved; zero net loss verified.

## 2026-09-08T02:50:40Z | gwas_catalog | rs7412

**Entry ID:** gwas_catalog-e7734b384a92987c
**Alert class:** standard
**Change summary:** 1 new GWAS Catalog association(s) for rs7412: 223076783 (p=1e-143, beta 0.278)
**Detector trigger:** GWAS Catalog published association records for this variant that were absent at the previous check.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gwas_catalog
**Rule invoked:** vegs_new_gwas_association_review
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-09-08T02:50:40Z | gwas_catalog | rs6983267

**Entry ID:** gwas_catalog-c4c74756871df108
**Alert class:** standard
**Change summary:** 3 new GWAS Catalog association(s) for rs6983267: 223082151 (p=5e-10, OR 1.2151), 223082988 (p=8e-74, OR 1.239), 223170878 (p=2e-122, beta 0.151)
**Detector trigger:** GWAS Catalog published association records for this variant that were absent at the previous check.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gwas_catalog
**Rule invoked:** vegs_new_gwas_association_review
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-09-08T02:50:40Z | gwas_catalog | rs174537

**Entry ID:** gwas_catalog-699ab4360724946f
**Alert class:** standard
**Change summary:** 1 new GWAS Catalog association(s) for rs174537: 223170966 (p=2e-21, beta 0.0643)
**Detector trigger:** GWAS Catalog published association records for this variant that were absent at the previous check.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gwas_catalog
**Rule invoked:** vegs_new_gwas_association_review
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-09-08T02:50:40Z | gwas_catalog | rs10936599

**Entry ID:** gwas_catalog-9d357ed6e4865483
**Alert class:** standard
**Change summary:** 1 new GWAS Catalog association(s) for rs10936599: 223170690 (p=1e-13, beta 0.0533)
**Detector trigger:** GWAS Catalog published association records for this variant that were absent at the previous check.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gwas_catalog
**Rule invoked:** vegs_new_gwas_association_review
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-09-04T11:56:47Z | workflow_health | workflow:detector-gnomad-currency.yml

**Entry ID:** workflow_health-4d8fa8195d07add6
**Alert class:** standard
**Change summary:** detector-gnomad-currency.yml last run concluded 'failure' (0.1 days ago)
**Detector trigger:** Scheduled workflow health sweep found a workflow that is failing, stale, or has never run.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** github_actions
**Rule invoked:** vegs_scheduled_workflow_health
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-09-01T12:18:54Z | workflow_health | workflow:detector-clinvar-tsv.yml

**Entry ID:** workflow_health-5f3fe364b9560cd1
**Alert class:** standard
**Change summary:** detector-clinvar-tsv.yml last run concluded 'failure' (0.3 days ago)
**Detector trigger:** Scheduled workflow health sweep found a workflow that is failing, stale, or has never run.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** github_actions
**Rule invoked:** vegs_scheduled_workflow_health
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-25T01:01:25Z | gwas_catalog | rs7903146

**Entry ID:** gwas_catalog-4649975db8f714e5
**Alert class:** standard
**Change summary:** 2 new GWAS Catalog association(s) for rs7903146: 222833789 (p=3e-12, OR 1.04), 222840762 (p=3e-10, beta 0.0309)
**Detector trigger:** GWAS Catalog published association records for this variant that were absent at the previous check.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gwas_catalog
**Rule invoked:** vegs_new_gwas_association_review
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-25T01:01:25Z | gwas_catalog | rs7412

**Entry ID:** gwas_catalog-ecd11ef4f2595da1
**Alert class:** standard
**Change summary:** 3 new GWAS Catalog association(s) for rs7412: 222843990 (p=2e-107, beta 0.402), 222845602 (p=6e-223, beta 0.623), 222846416 (p=1e-91, beta 0.466)
**Detector trigger:** GWAS Catalog published association records for this variant that were absent at the previous check.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gwas_catalog
**Rule invoked:** vegs_new_gwas_association_review
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-25T01:01:25Z | gwas_catalog | rs6265

**Entry ID:** gwas_catalog-ae6cd4b0877fee75
**Alert class:** standard
**Change summary:** 1 new GWAS Catalog association(s) for rs6265: 222911023 (p=4.9999999999999996e-06, beta 0.0387)
**Detector trigger:** GWAS Catalog published association records for this variant that were absent at the previous check.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gwas_catalog
**Rule invoked:** vegs_new_gwas_association_review
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-25T01:01:25Z | gwas_catalog | rs429358

**Entry ID:** gwas_catalog-9dd2c59eb13ed854
**Alert class:** standard
**Change summary:** 10 new GWAS Catalog association(s) for rs429358: 222844982 (p=1e-39, beta 0.187), 222845457 (p=2e-50, beta 0.169), 222970969 (p=4e-06, beta 0.2557), and 7 more
**Detector trigger:** GWAS Catalog published association records for this variant that were absent at the previous check.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gwas_catalog
**Rule invoked:** vegs_new_gwas_association_review
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-25T01:01:25Z | gwas_catalog | rs4149056

**Entry ID:** gwas_catalog-df61550bb0b342e4
**Alert class:** standard
**Change summary:** 5 new GWAS Catalog association(s) for rs4149056: 222844715 (p=2.9999999999999997e-44, beta 0.19), 223044046 (p=1e-11, no effect size), 223044096 (p=1e-14, no effect size), and 2 more
**Detector trigger:** GWAS Catalog published association records for this variant that were absent at the previous check.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gwas_catalog
**Rule invoked:** vegs_new_gwas_association_review
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-25T01:01:25Z | gwas_catalog | rs2476601

**Entry ID:** gwas_catalog-857e2550c0aa9f3e
**Alert class:** standard
**Change summary:** 1 new GWAS Catalog association(s) for rs2476601: 222840578 (p=2e-08, OR 1.0325)
**Detector trigger:** GWAS Catalog published association records for this variant that were absent at the previous check.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gwas_catalog
**Rule invoked:** vegs_new_gwas_association_review
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-25T01:01:25Z | gwas_catalog | rs1801133

**Entry ID:** gwas_catalog-d46f45c2ebab360f
**Alert class:** standard
**Change summary:** 1 new GWAS Catalog association(s) for rs1801133: 222845103 (p=8e-38, beta 0.172)
**Detector trigger:** GWAS Catalog published association records for this variant that were absent at the previous check.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gwas_catalog
**Rule invoked:** vegs_new_gwas_association_review
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-25T01:01:25Z | gwas_catalog | rs1800562

**Entry ID:** gwas_catalog-d4619fd2ce27545d
**Alert class:** standard
**Change summary:** 3 new GWAS Catalog association(s) for rs1800562: 223044516 (p=6.000000000000001e-13, beta 0.019), 223044772 (p=6e-14, no effect size), 223044982 (p=2e-13, beta 0.12)
**Detector trigger:** GWAS Catalog published association records for this variant that were absent at the previous check.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gwas_catalog
**Rule invoked:** vegs_new_gwas_association_review
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-25T01:01:25Z | gwas_catalog | rs1799945

**Entry ID:** gwas_catalog-b7e2885ba9ed478a
**Alert class:** standard
**Change summary:** 1 new GWAS Catalog association(s) for rs1799945: 222913458 (p=5e-14, beta 0.1668)
**Detector trigger:** GWAS Catalog published association records for this variant that were absent at the previous check.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gwas_catalog
**Rule invoked:** vegs_new_gwas_association_review
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-24T07:54:22Z | workflow_health | workflow:sources-review-registry.yml

**Entry ID:** workflow_health-92481d3f736f1101
**Alert class:** standard
**Change summary:** sources-review-registry.yml last run concluded 'failure' (0.0 days ago)
**Detector trigger:** Scheduled workflow health sweep found a workflow that is failing, stale, or has never run.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** github_actions
**Rule invoked:** vegs_scheduled_workflow_health
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-23T01:01:50Z | clinvar | cardiovascular_lipid|rs1799963|genotypes|A%2CA

**Entry ID:** clinvar-2b188fa983230ed2
**Alert class:** standard
**Change summary:** ClinVar Miner conflicting SCV count changed from 0 to 1.
**Detector trigger:** ClinVar Miner conflict-report count changed for tracked VCV.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** clinvar
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-23T01:01:50Z | clinvar | cardiovascular_lipid|rs1799963|genotypes|G%2CA

**Entry ID:** clinvar-a0ee555b8cf55c19
**Alert class:** standard
**Change summary:** ClinVar Miner conflicting SCV count changed from 0 to 1.
**Detector trigger:** ClinVar Miner conflict-report count changed for tracked VCV.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** clinvar
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-23T01:01:50Z | clinvar | cardiovascular_lipid|rs1799963|genotypes|G%2CG

**Entry ID:** clinvar-43cb758f55a6d2a8
**Alert class:** standard
**Change summary:** ClinVar Miner conflicting SCV count changed from 0 to 1.
**Detector trigger:** ClinVar Miner conflict-report count changed for tracked VCV.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** clinvar
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-23T01:01:50Z | clinvar | cardiovascular_lipid|rs1799963|insights|A%2CA

**Entry ID:** clinvar-7775476ae5a09d08
**Alert class:** standard
**Change summary:** ClinVar Miner conflicting SCV count changed from 0 to 1.
**Detector trigger:** ClinVar Miner conflict-report count changed for tracked VCV.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** clinvar
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-23T01:01:50Z | clinvar | cardiovascular_lipid|rs1799963|insights|G%2CA

**Entry ID:** clinvar-f668992c07345863
**Alert class:** standard
**Change summary:** ClinVar Miner conflicting SCV count changed from 0 to 1.
**Detector trigger:** ClinVar Miner conflict-report count changed for tracked VCV.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** clinvar
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-23T01:01:50Z | clinvar | cardiovascular_lipid|rs1799963|insights|G%2CG

**Entry ID:** clinvar-c5dbc033882de12b
**Alert class:** standard
**Change summary:** ClinVar Miner conflicting SCV count changed from 0 to 1.
**Detector trigger:** ClinVar Miner conflict-report count changed for tracked VCV.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** clinvar
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-23T01:01:50Z | clinvar | cardiovascular_lipid|rs6025|genotypes|T%2CT

**Entry ID:** clinvar-6b2642e2c20e8182
**Alert class:** standard
**Change summary:** ClinVar Miner conflicting SCV count changed from 0 to 1.
**Detector trigger:** ClinVar Miner conflict-report count changed for tracked VCV.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** clinvar
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-23T01:01:50Z | clinvar | cardiovascular_lipid|rs6025|genotypes|C%2CT

**Entry ID:** clinvar-c83700bd0bf7ecf5
**Alert class:** standard
**Change summary:** ClinVar Miner conflicting SCV count changed from 0 to 1.
**Detector trigger:** ClinVar Miner conflict-report count changed for tracked VCV.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** clinvar
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-23T01:01:50Z | clinvar | cardiovascular_lipid|rs6025|genotypes|C%2CC

**Entry ID:** clinvar-49b7288a2d22013d
**Alert class:** standard
**Change summary:** ClinVar Miner conflicting SCV count changed from 0 to 1.
**Detector trigger:** ClinVar Miner conflict-report count changed for tracked VCV.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** clinvar
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-23T01:01:50Z | clinvar | cardiovascular_lipid|rs6025|insights|T%2CT

**Entry ID:** clinvar-54e8e09702115674
**Alert class:** standard
**Change summary:** ClinVar Miner conflicting SCV count changed from 0 to 1.
**Detector trigger:** ClinVar Miner conflict-report count changed for tracked VCV.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** clinvar
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-23T01:01:50Z | clinvar | cardiovascular_lipid|rs6025|insights|C%2CT

**Entry ID:** clinvar-c46d7739dd1feae5
**Alert class:** standard
**Change summary:** ClinVar Miner conflicting SCV count changed from 0 to 1.
**Detector trigger:** ClinVar Miner conflict-report count changed for tracked VCV.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** clinvar
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-23T01:01:50Z | clinvar | cardiovascular_lipid|rs6025|insights|C%2CC

**Entry ID:** clinvar-0338093cd2e2f933
**Alert class:** standard
**Change summary:** ClinVar Miner conflicting SCV count changed from 0 to 1.
**Detector trigger:** ClinVar Miner conflict-report count changed for tracked VCV.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** clinvar
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-23T01:01:50Z | clinvar | cardiovascular_lipid|rs11591147|genotypes|T%2CT

**Entry ID:** clinvar-1cc315cb1f246bf9
**Alert class:** standard
**Change summary:** ClinVar Miner conflicting SCV count changed from 0 to 1.
**Detector trigger:** ClinVar Miner conflict-report count changed for tracked VCV.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** clinvar
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-23T01:01:50Z | clinvar | cardiovascular_lipid|rs11591147|genotypes|G%2CT

**Entry ID:** clinvar-05a34788438c2f6d
**Alert class:** standard
**Change summary:** ClinVar Miner conflicting SCV count changed from 0 to 1.
**Detector trigger:** ClinVar Miner conflict-report count changed for tracked VCV.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** clinvar
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-23T01:01:50Z | clinvar | cardiovascular_lipid|rs11591147|genotypes|G%2CG

**Entry ID:** clinvar-f8ff4414c0092805
**Alert class:** standard
**Change summary:** ClinVar Miner conflicting SCV count changed from 0 to 1.
**Detector trigger:** ClinVar Miner conflict-report count changed for tracked VCV.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** clinvar
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T07:34:26Z | workflow_health | workflow:catalog-deep-checks.yml

**Entry ID:** workflow_health-c87bf50979c8b3cd
**Alert class:** standard
**Change summary:** catalog-deep-checks.yml last run concluded 'failure' (0.2 days ago)
**Detector trigger:** Scheduled workflow health sweep found a workflow that is failing, stale, or has never run.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** github_actions
**Rule invoked:** vegs_scheduled_workflow_health
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|A%2CA

**Entry ID:** cpic-4f381c5e469afa5a
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CA

**Entry ID:** cpic-2e36868525bb34ef
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CG

**Entry ID:** cpic-1a7f33257fc72d6f
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|C%2CC

**Entry ID:** cpic-f4e8500ff7b097fc
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CC

**Entry ID:** cpic-2451f3770fc52c64
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CA

**Entry ID:** cpic-1c73a070571488db
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | neuro_pharmacogenomics|rs1057910|insights|C%2CC

**Entry ID:** cpic-b299102d77e88849
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CC

**Entry ID:** cpic-7ac4b4dea0d7a8b9
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CA

**Entry ID:** cpic-cf65d34c3b1a0d9d
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|T%2CT

**Entry ID:** cpic-0d0b72e62a5a17f9
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CT

**Entry ID:** cpic-62e71452b6d57255
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CC

**Entry ID:** cpic-24eb52e952ea7f5c
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | cardiovascular_lipid|rs9923231|genotypes|T%2CT

**Entry ID:** cpic-71b6df048162f485
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | cardiovascular_lipid|rs9923231|genotypes|C%2CT

**Entry ID:** cpic-a1bb58ca683b70b8
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | cardiovascular_lipid|rs9923231|genotypes|C%2CC

**Entry ID:** cpic-c2e98cce37e7d6e6
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | cardiovascular_lipid|rs9923231|insights|T%2CT

**Entry ID:** cpic-97a2f1e03f93c5a9
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | cardiovascular_lipid|rs9923231|insights|C%2CT

**Entry ID:** cpic-1691188ff5828816
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | cardiovascular_lipid|rs9923231|insights|C%2CC

**Entry ID:** cpic-9eb1a212150c800f
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | cardiovascular_lipid|rs4149056|genotypes|C%2CC

**Entry ID:** cpic-7f6f623e2b041e43
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | cardiovascular_lipid|rs4149056|genotypes|T%2CC

**Entry ID:** cpic-9815515082d8f611
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | cardiovascular_lipid|rs4149056|genotypes|T%2CT

**Entry ID:** cpic-39b2de4be283a37d
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-19T01:19:24Z | cpic | catalog-wide

**Entry ID:** cpic-16385318d1db741e
**Alert class:** pathogenic
**Change summary:** CPIC data schema version changed from v1.60.0 to v1.60.1.
**Detector trigger:** CPIC data release/version field changed; halt affected variant surfacing pending reconciliation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Closed at:** N/A
**Reclassification:** none
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** vegs_section_10_detector_2_schema_version_change
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-18T07:33:50Z | workflow_health | workflow:sources-review-registry.yml

**Entry ID:** workflow_health-c551bd7e54ce8bc3
**Alert class:** standard
**Change summary:** sources-review-registry.yml has never run
**Detector trigger:** Scheduled workflow health sweep found a workflow that is failing, stale, or has never run.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** github_actions
**Rule invoked:** vegs_scheduled_workflow_health
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-18T07:33:50Z | workflow_health | workflow:catalog-integrity.yml

**Entry ID:** workflow_health-14fd6020bd710bd2
**Alert class:** standard
**Change summary:** catalog-integrity.yml last run concluded 'failure' (0.2 days ago)
**Detector trigger:** Scheduled workflow health sweep found a workflow that is failing, stale, or has never run.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** github_actions
**Rule invoked:** vegs_scheduled_workflow_health
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-17T17:17:13Z | gnomad_currency | rs6983267

**Entry ID:** gnomad_currency-c20ea08f5209f954
**Alert class:** standard
**Change summary:** rs6983267 gnomAD global AF drifted 34.5% relative (catalog 0.38150387800709873, live 0.25; threshold 20%)
**Detector trigger:** Live gnomAD global allele frequency differs from the catalog-stored value by more than the drift threshold.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gnomad
**Rule invoked:** vegs_gnomad_frequency_drift
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-16T01:00:36Z | clinvar | cardiovascular_lipid|rs11591147|genotypes|T%2CT

**Entry ID:** clinvar-3b64093594490cb3
**Alert class:** standard
**Change summary:** ClinVar Miner conflicting SCV count changed from 1 to 0.
**Detector trigger:** ClinVar Miner conflict-report count changed for tracked VCV.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** clinvar
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-16T01:00:36Z | clinvar | cardiovascular_lipid|rs11591147|genotypes|G%2CT

**Entry ID:** clinvar-4fe8f2b54692e639
**Alert class:** standard
**Change summary:** ClinVar Miner conflicting SCV count changed from 1 to 0.
**Detector trigger:** ClinVar Miner conflict-report count changed for tracked VCV.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** clinvar
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-16T01:00:36Z | clinvar | cardiovascular_lipid|rs11591147|genotypes|G%2CG

**Entry ID:** clinvar-752446823e9b2d63
**Alert class:** standard
**Change summary:** ClinVar Miner conflicting SCV count changed from 1 to 0.
**Detector trigger:** ClinVar Miner conflict-report count changed for tracked VCV.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** clinvar
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|A%2CA

**Entry ID:** cpic-34ada178412cd98e
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.0.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|A%2CA

**Entry ID:** cpic-08b6883bbe1d3e53
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Proton Pump Inhibitors version changed from 67 to 68.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|A%2CA

**Entry ID:** cpic-71467cca54356884
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants version changed from 24 to 25.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|A%2CA

**Entry ID:** cpic-a81d78e54eacd7ef
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19 and Tricyclic Antidepressants version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|A%2CA

**Entry ID:** cpic-8ee62ea4c68bbe81
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Voriconazole version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|A%2CA

**Entry ID:** cpic-1d2c373d3303949a
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Clopidogrel version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CA

**Entry ID:** cpic-6878a47faec84c98
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.0.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CA

**Entry ID:** cpic-a26a9880a7b48a03
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Proton Pump Inhibitors version changed from 67 to 68.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CA

**Entry ID:** cpic-e451ec9c576507cc
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants version changed from 24 to 25.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CA

**Entry ID:** cpic-9270e80dddd3522c
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19 and Tricyclic Antidepressants version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CA

**Entry ID:** cpic-644e5fb6426d58d1
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Voriconazole version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CA

**Entry ID:** cpic-59725c6a7d105bce
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Clopidogrel version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CG

**Entry ID:** cpic-6c63a97fa264ca36
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.0.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CG

**Entry ID:** cpic-a8f48bd92f1ee1f8
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Proton Pump Inhibitors version changed from 67 to 68.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CG

**Entry ID:** cpic-a692aac1b65eddc4
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants version changed from 24 to 25.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CG

**Entry ID:** cpic-ad6ec97959e17b66
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19 and Tricyclic Antidepressants version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CG

**Entry ID:** cpic-f023a99499e031fd
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Voriconazole version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CG

**Entry ID:** cpic-9eda71265bcda426
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Clopidogrel version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|C%2CC

**Entry ID:** cpic-32f9bf372f5bde03
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.0.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|C%2CC

**Entry ID:** cpic-41d254a06f0c0329
**Alert class:** standard
**Change summary:** CPIC guideline SLCO1B1, ABCG2, CYP2C9, and Statins version changed from 71 to 72.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|C%2CC

**Entry ID:** cpic-2628435ec5e86382
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 71 to 72.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|C%2CC

**Entry ID:** cpic-9f9b9e63370ea6eb
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, HLA-B and Phenytoin version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|C%2CC

**Entry ID:** cpic-c137ec67389d6b6d
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9 and NSAIDs version changed from 68 to 69.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CC

**Entry ID:** cpic-7d7cbe389dd5ec85
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.0.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CC

**Entry ID:** cpic-9c378270ddac2a50
**Alert class:** standard
**Change summary:** CPIC guideline SLCO1B1, ABCG2, CYP2C9, and Statins version changed from 71 to 72.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CC

**Entry ID:** cpic-0d83c1a8df38b715
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 71 to 72.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CC

**Entry ID:** cpic-844115871c7f3822
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, HLA-B and Phenytoin version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CC

**Entry ID:** cpic-b8adc4db82dbbe46
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9 and NSAIDs version changed from 68 to 69.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CA

**Entry ID:** cpic-46a7c034913562d2
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.0.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CA

**Entry ID:** cpic-b280954618bfcb1c
**Alert class:** standard
**Change summary:** CPIC guideline SLCO1B1, ABCG2, CYP2C9, and Statins version changed from 71 to 72.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CA

**Entry ID:** cpic-25c16499725635a2
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 71 to 72.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CA

**Entry ID:** cpic-068439d081314f8d
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, HLA-B and Phenytoin version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CA

**Entry ID:** cpic-32b0d806a9a20254
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9 and NSAIDs version changed from 68 to 69.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|insights|C%2CC

**Entry ID:** cpic-69d95139d7094310
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.0.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|insights|C%2CC

**Entry ID:** cpic-00b45ee22c807bc7
**Alert class:** standard
**Change summary:** CPIC guideline SLCO1B1, ABCG2, CYP2C9, and Statins version changed from 71 to 72.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|insights|C%2CC

**Entry ID:** cpic-c83e5081fe03e229
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 71 to 72.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|insights|C%2CC

**Entry ID:** cpic-8587240cfd071fdb
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, HLA-B and Phenytoin version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|insights|C%2CC

**Entry ID:** cpic-558f92724a8ce56f
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9 and NSAIDs version changed from 68 to 69.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CC

**Entry ID:** cpic-2be4ef2b965274d9
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.0.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CC

**Entry ID:** cpic-269897c51f12121f
**Alert class:** standard
**Change summary:** CPIC guideline SLCO1B1, ABCG2, CYP2C9, and Statins version changed from 71 to 72.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CC

**Entry ID:** cpic-89dfedcb5b7db059
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 71 to 72.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CC

**Entry ID:** cpic-321449bb3f4e1ee4
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, HLA-B and Phenytoin version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CC

**Entry ID:** cpic-7b65648fae2ca2b7
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9 and NSAIDs version changed from 68 to 69.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CA

**Entry ID:** cpic-29bf33231a833f76
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.0.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CA

**Entry ID:** cpic-874a45dfe77e7f8f
**Alert class:** standard
**Change summary:** CPIC guideline SLCO1B1, ABCG2, CYP2C9, and Statins version changed from 71 to 72.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CA

**Entry ID:** cpic-d9f1d1c928cecff8
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 71 to 72.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CA

**Entry ID:** cpic-49b4949449f1cfc9
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, HLA-B and Phenytoin version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CA

**Entry ID:** cpic-8b75eaaeefe55f9e
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9 and NSAIDs version changed from 68 to 69.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|T%2CT

**Entry ID:** cpic-04659821c6f36ff1
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.0.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|T%2CT

**Entry ID:** cpic-97e2050d3fc226f2
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Proton Pump Inhibitors version changed from 67 to 68.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|T%2CT

**Entry ID:** cpic-c6c7db6bfdc75fae
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants version changed from 24 to 25.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|T%2CT

**Entry ID:** cpic-ab8041b28694b721
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19 and Tricyclic Antidepressants version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|T%2CT

**Entry ID:** cpic-1dbdbd96d1e92d5c
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Voriconazole version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|T%2CT

**Entry ID:** cpic-1319d60ac5a44baa
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Clopidogrel version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CT

**Entry ID:** cpic-88f711e12b31eced
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.0.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CT

**Entry ID:** cpic-e114a94214d10184
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Proton Pump Inhibitors version changed from 67 to 68.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CT

**Entry ID:** cpic-00ec91b532e366e2
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants version changed from 24 to 25.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CT

**Entry ID:** cpic-1f5e9de807a1a75a
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19 and Tricyclic Antidepressants version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CT

**Entry ID:** cpic-4b45f8a9003653d5
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Voriconazole version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CT

**Entry ID:** cpic-4a84b771201f0de0
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Clopidogrel version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CC

**Entry ID:** cpic-88ad7ab64201b6d1
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.0.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CC

**Entry ID:** cpic-20da8fbe4ad2d9f8
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Proton Pump Inhibitors version changed from 67 to 68.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CC

**Entry ID:** cpic-e73a97b70166c70f
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants version changed from 24 to 25.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CC

**Entry ID:** cpic-5c25ef9fe2389646
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19 and Tricyclic Antidepressants version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CC

**Entry ID:** cpic-081a9e29db64d41b
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Voriconazole version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CC

**Entry ID:** cpic-227a1eb736c2c911
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Clopidogrel version changed from 70 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | cardiovascular_lipid|rs9923231|genotypes|T%2CT

**Entry ID:** cpic-ba418f3cb6400554
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.0.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | cardiovascular_lipid|rs9923231|genotypes|T%2CT

**Entry ID:** cpic-53f24dc370dc99ac
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 71 to 72.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | cardiovascular_lipid|rs9923231|genotypes|C%2CT

**Entry ID:** cpic-1511bccde45b30eb
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.0.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | cardiovascular_lipid|rs9923231|genotypes|C%2CT

**Entry ID:** cpic-1fd162315a961368
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 71 to 72.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | cardiovascular_lipid|rs9923231|genotypes|C%2CC

**Entry ID:** cpic-27ac93345d33e9e1
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.0.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | cardiovascular_lipid|rs9923231|genotypes|C%2CC

**Entry ID:** cpic-02b78adf7a02e26f
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 71 to 72.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | cardiovascular_lipid|rs9923231|insights|T%2CT

**Entry ID:** cpic-2d8fe27cf0ec2f95
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.0.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | cardiovascular_lipid|rs9923231|insights|T%2CT

**Entry ID:** cpic-d0551b4964387686
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 71 to 72.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | cardiovascular_lipid|rs9923231|insights|C%2CT

**Entry ID:** cpic-a9646874c4fcab38
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.0.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | cardiovascular_lipid|rs9923231|insights|C%2CT

**Entry ID:** cpic-36c4b7b38aa14bce
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 71 to 72.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | cardiovascular_lipid|rs9923231|insights|C%2CC

**Entry ID:** cpic-c278310e3f49af38
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.0.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | cardiovascular_lipid|rs9923231|insights|C%2CC

**Entry ID:** cpic-4702a3ee7c6ac9e2
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 71 to 72.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | cardiovascular_lipid|rs4149056|genotypes|C%2CC

**Entry ID:** cpic-41afc817e5801b7c
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.0.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | cardiovascular_lipid|rs4149056|genotypes|C%2CC

**Entry ID:** cpic-b33a2da90886d534
**Alert class:** standard
**Change summary:** CPIC guideline SLCO1B1, ABCG2, CYP2C9, and Statins version changed from 71 to 72.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | cardiovascular_lipid|rs4149056|genotypes|T%2CC

**Entry ID:** cpic-aca8e2005272a49d
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.0.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | cardiovascular_lipid|rs4149056|genotypes|T%2CC

**Entry ID:** cpic-f45e8227bac25208
**Alert class:** standard
**Change summary:** CPIC guideline SLCO1B1, ABCG2, CYP2C9, and Statins version changed from 71 to 72.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | cardiovascular_lipid|rs4149056|genotypes|T%2CT

**Entry ID:** cpic-c65fcce4b8802d55
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.60.0.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | cardiovascular_lipid|rs4149056|genotypes|T%2CT

**Entry ID:** cpic-3526f92d84b7af67
**Alert class:** standard
**Change summary:** CPIC guideline SLCO1B1, ABCG2, CYP2C9, and Statins version changed from 71 to 72.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-12T02:04:10Z | cpic | catalog-wide

**Entry ID:** cpic-b8f01dc32dfa98d6
**Alert class:** pathogenic
**Change summary:** CPIC data schema version changed from v1.59.1 to v1.60.0.
**Detector trigger:** CPIC data release/version field changed; halt affected variant surfacing pending reconciliation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** vegs_section_10_detector_2_schema_version_change
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-06T04:06:11Z | workflow_health | workflow:voice-anchor-rotation-quarterly.yml

**Entry ID:** workflow_health-e61991341c5b7cb7
**Alert class:** standard
**Change summary:** voice-anchor-rotation-quarterly.yml last run concluded 'failure' (35.5 days ago)
**Detector trigger:** Scheduled workflow health sweep found a workflow that is failing, stale, or has never run.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** github_actions
**Rule invoked:** vegs_scheduled_workflow_health
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-06T04:06:11Z | workflow_health | workflow:detector-workflow-health.yml

**Entry ID:** workflow_health-9a8aba6347fd258f
**Alert class:** standard
**Change summary:** detector-workflow-health.yml has never run
**Detector trigger:** Scheduled workflow health sweep found a workflow that is failing, stale, or has never run.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** github_actions
**Rule invoked:** vegs_scheduled_workflow_health
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-06T04:06:11Z | workflow_health | workflow:detector-pmid-resolves.yml

**Entry ID:** workflow_health-1ee6d7bd827de267
**Alert class:** standard
**Change summary:** detector-pmid-resolves.yml has never run
**Detector trigger:** Scheduled workflow health sweep found a workflow that is failing, stale, or has never run.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** github_actions
**Rule invoked:** vegs_scheduled_workflow_health
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-06T04:06:11Z | workflow_health | workflow:detector-gwas-catalog.yml

**Entry ID:** workflow_health-87c1d2f586b68966
**Alert class:** standard
**Change summary:** detector-gwas-catalog.yml has never run
**Detector trigger:** Scheduled workflow health sweep found a workflow that is failing, stale, or has never run.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** github_actions
**Rule invoked:** vegs_scheduled_workflow_health
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-06T04:06:11Z | workflow_health | workflow:detector-gnomad-currency.yml

**Entry ID:** workflow_health-79cff0d26689e29b
**Alert class:** standard
**Change summary:** detector-gnomad-currency.yml has never run
**Detector trigger:** Scheduled workflow health sweep found a workflow that is failing, stale, or has never run.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** github_actions
**Rule invoked:** vegs_scheduled_workflow_health
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-06T04:06:11Z | workflow_health | workflow:detector-giab-release.yml

**Entry ID:** workflow_health-c5f800697d10a904
**Alert class:** standard
**Change summary:** detector-giab-release.yml has never run
**Detector trigger:** Scheduled workflow health sweep found a workflow that is failing, stale, or has never run.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** github_actions
**Rule invoked:** vegs_scheduled_workflow_health
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-06T04:06:11Z | workflow_health | workflow:api-smoke-monthly.yml

**Entry ID:** workflow_health-a53c08756cbb77aa
**Alert class:** standard
**Change summary:** api-smoke-monthly.yml last run concluded 'failure' (4.8 days ago)
**Detector trigger:** Scheduled workflow health sweep found a workflow that is failing, stale, or has never run.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** github_actions
**Rule invoked:** vegs_scheduled_workflow_health
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-06T03:11:32Z | gnomad_currency | rs9543325

**Entry ID:** gnomad_currency-fef52b68025d1cdf
**Alert class:** standard
**Change summary:** rs9543325 gnomAD global AF drifted 43.9% relative (catalog 0.866, live 0.4854367016168287; threshold 20%)
**Detector trigger:** Live gnomAD global allele frequency differs from the catalog-stored value by more than the drift threshold.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gnomad
**Rule invoked:** vegs_gnomad_frequency_drift
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-06T03:09:36Z | gnomad_currency | rs910873

**Entry ID:** gnomad_currency-df1f25b3b4357959
**Alert class:** standard
**Change summary:** rs910873 gnomAD global AF drifted 95.4% relative (catalog 0.9998, live 0.04579962172953662; threshold 20%)
**Detector trigger:** Live gnomAD global allele frequency differs from the catalog-stored value by more than the drift threshold.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gnomad
**Rule invoked:** vegs_gnomad_frequency_drift
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-06T03:09:36Z | gnomad_currency | rs6983267

**Entry ID:** gnomad_currency-1f3d443b3d906277
**Alert class:** standard
**Change summary:** rs6983267 gnomAD global AF drifted 75.0% relative (catalog 1.0, live 0.25; threshold 20%)
**Detector trigger:** Live gnomAD global allele frequency differs from the catalog-stored value by more than the drift threshold.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gnomad
**Rule invoked:** vegs_gnomad_frequency_drift
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-06T03:09:36Z | gnomad_currency | rs4779584

**Entry ID:** gnomad_currency-4955f179cf5be9a2
**Alert class:** standard
**Change summary:** rs4779584 gnomAD global AF drifted 26.7% relative (catalog 0.9108, live 0.6678258240096765; threshold 20%)
**Detector trigger:** Live gnomAD global allele frequency differs from the catalog-stored value by more than the drift threshold.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gnomad
**Rule invoked:** vegs_gnomad_frequency_drift
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-06T03:09:36Z | gnomad_currency | rs4430796

**Entry ID:** gnomad_currency-10889f72f717eb6f
**Alert class:** standard
**Change summary:** rs4430796 gnomAD global AF drifted 27.8% relative (catalog 0.7076, live 0.5109608147582831; threshold 20%)
**Detector trigger:** Live gnomAD global allele frequency differs from the catalog-stored value by more than the drift threshold.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gnomad
**Rule invoked:** vegs_gnomad_frequency_drift
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-06T03:09:36Z | gnomad_currency | rs3814113

**Entry ID:** gnomad_currency-9e66f1b9fac0c8db
**Alert class:** standard
**Change summary:** rs3814113 gnomAD global AF drifted 42.6% relative (catalog 0.7184, live 0.412629096848983; threshold 20%)
**Detector trigger:** Live gnomAD global allele frequency differs from the catalog-stored value by more than the drift threshold.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gnomad
**Rule invoked:** vegs_gnomad_frequency_drift
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-06T03:09:36Z | gnomad_currency | rs13387042

**Entry ID:** gnomad_currency-58532cf2d9e1c98c
**Alert class:** standard
**Change summary:** rs13387042 gnomAD global AF drifted 50.4% relative (catalog 0.902, live 0.44718916431060557; threshold 20%)
**Detector trigger:** Live gnomAD global allele frequency differs from the catalog-stored value by more than the drift threshold.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gnomad
**Rule invoked:** vegs_gnomad_frequency_drift
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-06T03:09:36Z | gnomad_currency | rs1143679

**Entry ID:** gnomad_currency-dd78a4e78b913637
**Alert class:** standard
**Change summary:** rs1143679 gnomAD global AF drifted 89.9% relative (catalog 0.9981, live 0.10061226614834612; threshold 20%)
**Detector trigger:** Live gnomAD global allele frequency differs from the catalog-stored value by more than the drift threshold.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gnomad
**Rule invoked:** vegs_gnomad_frequency_drift
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-06T03:09:36Z | gnomad_currency | rs10795668

**Entry ID:** gnomad_currency-2a6d31905b87869b
**Alert class:** standard
**Change summary:** rs10795668 gnomAD global AF drifted 73.9% relative (catalog 0.9395, live 0.24550929700444468; threshold 20%)
**Detector trigger:** Live gnomAD global allele frequency differs from the catalog-stored value by more than the drift threshold.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** gnomad
**Rule invoked:** vegs_gnomad_frequency_drift
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-08-05T17:58:50Z | giab_release | giab:HG002

**Entry ID:** giab_release-1545d9b7f38a2092
**Alert class:** standard
**Change summary:** GIAB HG002 has a newer benchmark release than the pinned NISTv4.2.1: v5.0q
**Detector trigger:** The scanner conformance harness is graded against a pinned GIAB release; a newer one is now published.
**Editor action:** Adopted 2026-08-05: HG002 pin moved from NISTv4.2.1 to v5.0q (Q100 smvar); HG001 and HG005 remain on NISTv4.2.1.
**Action rationale:** Sprint 69 WS2: GIAB publishes HG002 v5.0q as the current whole-genome small-variant benchmark. Regenerated tests/fixtures/scanner/giab/giab-truth.json with per-sample releases; conformance suite still requires 64 entries, unusable=0, empty ref_disagreements.
**SLA status:** closed 0 days within SLA
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** giab
**Rule invoked:** vegs_giab_benchmark_release_currency
**Override resolution status:** N/A
**Alert resolution criteria:** release_notes_reviewed=true; truth_fixture_regenerated_or_pin_justified=true; conformance_rerun=true; rationale_logged=true

## 2026-08-01T08:12:49Z | api_freshness_smoke | operational|monthly_api_smoke

**Entry ID:** api_freshness_smoke-da71713293d416e6
**Alert class:** standard
**Change summary:** Monthly API freshness smoke failed for external providers. Failures: pharmgkb (rs4149056): HTTPSConnectionPool(host='api.pharmgkb.org', port=443): Max retries exceeded with url: /v1/data/clinicalAnnotation?location.rsId=rs4149056 (Caused by NameResolutionError("HTTPSConnection(host='api.pharmgkb.org', port=443): Failed to resolve 'api.pharmgkb.org' ([Errno -2] Name or service not known)"))
**Detector trigger:** Scheduled HTTP probe for PharmGKB, OpenTargets, and PubMed E-utilities.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** sprint_50_api_smoke
**Rule invoked:** vegs_section_10_api_freshness_smoke
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-07-28T00:00:00Z | coordinate-integrity | cardiovascular_lipid|rs693

**Entry ID:** coord-rs693-grch38-2026-07-28
**Alert class:** standard
**Change summary:** Corrected APOB rs693 `pos_grch38` from 59991 to 21009323 (GRCh37 `pos` 21232195 unchanged). Provenance: Ensembl `NC_000002.12:g.21009323G>A`; NCBI dbSNP rs693 GRCh38.p14.
**Detector trigger:** Full-catalog Ensembl+dbSNP coordinate cross-check (2026-07-28); silent false-negative risk against GRCh38 gVCF reference blocks.
**Editor action:** Corrected 2026-07-28; catalog-coordinate truth file + CI gate installed.
**Action rationale:** Wrong GRCh38 coordinate converted a true heterozygous call into a false-negative reference-normal at chr2:59991.
**SLA status:** closed 0 days within SLA
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** ensembl+dbsnp
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=true; schema_updates_applied=true; rationale_logged=true; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|A%2CA

**Entry ID:** cpic-e949b799b82fa5fd
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.59.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|A%2CA

**Entry ID:** cpic-647d7f34c570b1e3
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Voriconazole version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|A%2CA

**Entry ID:** cpic-1ba7cd93e5a08898
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Proton Pump Inhibitors version changed from 65 to 67.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|A%2CA

**Entry ID:** cpic-dfaeb77122f5a006
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Clopidogrel version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|A%2CA

**Entry ID:** cpic-2f03da0b061fb68e
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants version changed from 22 to 24.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|A%2CA

**Entry ID:** cpic-1eb0eb93b41f7685
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19 and Tricyclic Antidepressants version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CA

**Entry ID:** cpic-14dacb990e91048d
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.59.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CA

**Entry ID:** cpic-c611ed35cc767203
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Voriconazole version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CA

**Entry ID:** cpic-d3c25a4c0738a150
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Proton Pump Inhibitors version changed from 65 to 67.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CA

**Entry ID:** cpic-720049329a9ee9c6
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Clopidogrel version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CA

**Entry ID:** cpic-5a82c260a3991373
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants version changed from 22 to 24.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CA

**Entry ID:** cpic-ca3636b34ba4d345
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19 and Tricyclic Antidepressants version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CG

**Entry ID:** cpic-9437667501b89972
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.59.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CG

**Entry ID:** cpic-aa249a5c96b96163
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Voriconazole version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CG

**Entry ID:** cpic-b0811bd24e0f4f17
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Proton Pump Inhibitors version changed from 65 to 67.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CG

**Entry ID:** cpic-2cce1b261e187696
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Clopidogrel version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CG

**Entry ID:** cpic-569becf2c49e6074
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants version changed from 22 to 24.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs4244285|genotypes|G%2CG

**Entry ID:** cpic-43eb863b65b7cff8
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19 and Tricyclic Antidepressants version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|C%2CC

**Entry ID:** cpic-65d472b75489637d
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.59.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|C%2CC

**Entry ID:** cpic-befbae3f9fd0ffcb
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 69 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|C%2CC

**Entry ID:** cpic-bf99d4ede38d6d7c
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, HLA-B and Phenytoin version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|C%2CC

**Entry ID:** cpic-187e5ba894213f21
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9 and NSAIDs version changed from 66 to 68.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|C%2CC

**Entry ID:** cpic-094dfcbb6c564fb6
**Alert class:** standard
**Change summary:** CPIC guideline SLCO1B1, ABCG2, CYP2C9, and Statins version changed from 69 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CC

**Entry ID:** cpic-0d44a7e1714a91e3
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.59.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CC

**Entry ID:** cpic-cdea73c929ea7027
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 69 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CC

**Entry ID:** cpic-9af9cfeaebd26f0e
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, HLA-B and Phenytoin version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CC

**Entry ID:** cpic-24e3011e4fe7808c
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9 and NSAIDs version changed from 66 to 68.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CC

**Entry ID:** cpic-b6705a6bd553e170
**Alert class:** standard
**Change summary:** CPIC guideline SLCO1B1, ABCG2, CYP2C9, and Statins version changed from 69 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CA

**Entry ID:** cpic-d1f0d50f7dee969a
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.59.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CA

**Entry ID:** cpic-f3e045da76fa53d8
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 69 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CA

**Entry ID:** cpic-567d0bbf898a382a
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, HLA-B and Phenytoin version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CA

**Entry ID:** cpic-1791f0ef15139c67
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9 and NSAIDs version changed from 66 to 68.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|genotypes|A%2CA

**Entry ID:** cpic-352a2fcfa64d7235
**Alert class:** standard
**Change summary:** CPIC guideline SLCO1B1, ABCG2, CYP2C9, and Statins version changed from 69 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|insights|C%2CC

**Entry ID:** cpic-7b0f5c65e353efe1
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.59.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|insights|C%2CC

**Entry ID:** cpic-c7677c87d081a091
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 69 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|insights|C%2CC

**Entry ID:** cpic-ac5275d83e52fb71
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, HLA-B and Phenytoin version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|insights|C%2CC

**Entry ID:** cpic-64c5a35f9559a6ed
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9 and NSAIDs version changed from 66 to 68.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|insights|C%2CC

**Entry ID:** cpic-f71ada38fa9b7e4a
**Alert class:** standard
**Change summary:** CPIC guideline SLCO1B1, ABCG2, CYP2C9, and Statins version changed from 69 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CC

**Entry ID:** cpic-b628f56661a0e91f
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.59.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CC

**Entry ID:** cpic-743447cb298f9439
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 69 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CC

**Entry ID:** cpic-59202aa63d72f2a1
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, HLA-B and Phenytoin version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CC

**Entry ID:** cpic-7c1f8747ba8d6227
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9 and NSAIDs version changed from 66 to 68.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CC

**Entry ID:** cpic-c8cb91a6d135a42d
**Alert class:** standard
**Change summary:** CPIC guideline SLCO1B1, ABCG2, CYP2C9, and Statins version changed from 69 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CA

**Entry ID:** cpic-5b4cceaf07ecae53
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.59.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CA

**Entry ID:** cpic-1cc1d6c3245666c8
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 69 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CA

**Entry ID:** cpic-170c7af0a489cd3e
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, HLA-B and Phenytoin version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CA

**Entry ID:** cpic-63b14d311bafdce7
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9 and NSAIDs version changed from 66 to 68.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs1057910|insights|A%2CA

**Entry ID:** cpic-cfb88cb6ec589039
**Alert class:** standard
**Change summary:** CPIC guideline SLCO1B1, ABCG2, CYP2C9, and Statins version changed from 69 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|T%2CT

**Entry ID:** cpic-af73628ae4226fc9
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.59.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|T%2CT

**Entry ID:** cpic-5a72b2346610a333
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Voriconazole version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|T%2CT

**Entry ID:** cpic-8a017f8faaac9d21
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Proton Pump Inhibitors version changed from 65 to 67.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|T%2CT

**Entry ID:** cpic-92006a4002ed407e
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Clopidogrel version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|T%2CT

**Entry ID:** cpic-19939eb094ae95c2
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants version changed from 22 to 24.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|T%2CT

**Entry ID:** cpic-652f01afc67d6b11
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19 and Tricyclic Antidepressants version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CT

**Entry ID:** cpic-bc195d3e37bed2a8
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.59.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CT

**Entry ID:** cpic-700aa4a1c7cb517f
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Voriconazole version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CT

**Entry ID:** cpic-ed47d58328248499
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Proton Pump Inhibitors version changed from 65 to 67.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CT

**Entry ID:** cpic-879ef6f12c66b113
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Clopidogrel version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CT

**Entry ID:** cpic-926156ecbff132ae
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants version changed from 22 to 24.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CT

**Entry ID:** cpic-38707af731bb47e3
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19 and Tricyclic Antidepressants version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CC

**Entry ID:** cpic-ed73443d1486f168
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.59.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CC

**Entry ID:** cpic-14d85abaf1b9ef2a
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Voriconazole version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CC

**Entry ID:** cpic-691bf9c9c373e56b
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Proton Pump Inhibitors version changed from 65 to 67.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CC

**Entry ID:** cpic-ca118ca017cce424
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C19 and Clopidogrel version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CC

**Entry ID:** cpic-ad6df830cef59912
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants version changed from 22 to 24.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | neuro_pharmacogenomics|rs12248560|genotypes|C%2CC

**Entry ID:** cpic-cc1ae80b612c08f7
**Alert class:** standard
**Change summary:** CPIC guideline CYP2D6, CYP2C19 and Tricyclic Antidepressants version changed from 68 to 70.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | cardiovascular_lipid|rs9923231|genotypes|T%2CT

**Entry ID:** cpic-e7ec34c425afb725
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.59.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | cardiovascular_lipid|rs9923231|genotypes|T%2CT

**Entry ID:** cpic-08f0dc859aa30e7c
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 69 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | cardiovascular_lipid|rs9923231|genotypes|C%2CT

**Entry ID:** cpic-4ed5d9ca80126029
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.59.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | cardiovascular_lipid|rs9923231|genotypes|C%2CT

**Entry ID:** cpic-940fdce904f2dfb4
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 69 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | cardiovascular_lipid|rs9923231|genotypes|C%2CC

**Entry ID:** cpic-a1b2b6b8b6c5949e
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.59.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | cardiovascular_lipid|rs9923231|genotypes|C%2CC

**Entry ID:** cpic-05035f9021d41ad9
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 69 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | cardiovascular_lipid|rs9923231|insights|T%2CT

**Entry ID:** cpic-005580aad1575bea
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.59.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | cardiovascular_lipid|rs9923231|insights|T%2CT

**Entry ID:** cpic-b7cd45cea6b487e8
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 69 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | cardiovascular_lipid|rs9923231|insights|C%2CT

**Entry ID:** cpic-51a04037f18878cd
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.59.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | cardiovascular_lipid|rs9923231|insights|C%2CT

**Entry ID:** cpic-6aac92ee8c43634a
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 69 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | cardiovascular_lipid|rs9923231|insights|C%2CC

**Entry ID:** cpic-801e81b96d056c6d
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.59.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | cardiovascular_lipid|rs9923231|insights|C%2CC

**Entry ID:** cpic-e372aa5fd1d25828
**Alert class:** standard
**Change summary:** CPIC guideline CYP2C9, VKORC1, CYP4F2 and Warfarin version changed from 69 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | cardiovascular_lipid|rs4149056|genotypes|C%2CC

**Entry ID:** cpic-38016d04bc93dac7
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.59.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | cardiovascular_lipid|rs4149056|genotypes|C%2CC

**Entry ID:** cpic-c1f16662f778f336
**Alert class:** standard
**Change summary:** CPIC guideline SLCO1B1, ABCG2, CYP2C9, and Statins version changed from 69 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | cardiovascular_lipid|rs4149056|genotypes|T%2CC

**Entry ID:** cpic-fa7f1660a02e0d85
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.59.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | cardiovascular_lipid|rs4149056|genotypes|T%2CC

**Entry ID:** cpic-3ba8fb1fca19c943
**Alert class:** standard
**Change summary:** CPIC guideline SLCO1B1, ABCG2, CYP2C9, and Statins version changed from 69 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | cardiovascular_lipid|rs4149056|genotypes|T%2CT

**Entry ID:** cpic-c7de62285c1d6e5c
**Alert class:** standard
**Change summary:** New CPIC data release detected: v1.59.1.
**Detector trigger:** GitHub release changed for cpicpgx/cpic-data.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | cardiovascular_lipid|rs4149056|genotypes|T%2CT

**Entry ID:** cpic-8c1ea24058260909
**Alert class:** standard
**Change summary:** CPIC guideline SLCO1B1, ABCG2, CYP2C9, and Statins version changed from 69 to 71.
**Detector trigger:** Tracked CPIC guideline version changed in CPIC PostgREST API.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-24T03:47:57Z | cpic | catalog-wide

**Entry ID:** cpic-4b16a92c52bada2f
**Alert class:** pathogenic
**Change summary:** CPIC data schema version changed from v1.58.0 to v1.59.1.
**Detector trigger:** CPIC data release/version field changed; halt affected variant surfacing pending reconciliation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** cpic
**Rule invoked:** vegs_section_10_detector_2_schema_version_change
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-11T01:31:10Z | pharmgkb | neuro_pharmacogenomics|rs4244285|genotypes|A%2CA

**Entry ID:** pharmgkb-28ad012dbd956b57
**Alert class:** standard
**Change summary:** New PharmGKB clinical annotation level observed: 3.
**Detector trigger:** Tracked variant gained a PharmGKB clinical annotation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** pharmgkb
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-11T01:31:10Z | pharmgkb | neuro_pharmacogenomics|rs4244285|genotypes|G%2CA

**Entry ID:** pharmgkb-6f47ce8f7d57de7c
**Alert class:** standard
**Change summary:** New PharmGKB clinical annotation level observed: 3.
**Detector trigger:** Tracked variant gained a PharmGKB clinical annotation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** pharmgkb
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-11T01:31:10Z | pharmgkb | neuro_pharmacogenomics|rs4244285|genotypes|G%2CG

**Entry ID:** pharmgkb-c2922e89a57ec9a6
**Alert class:** standard
**Change summary:** New PharmGKB clinical annotation level observed: 3.
**Detector trigger:** Tracked variant gained a PharmGKB clinical annotation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** pharmgkb
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-11T01:31:10Z | pharmgkb | neuro_pharmacogenomics|rs1057910|genotypes|C%2CC

**Entry ID:** pharmgkb-052abb0333774736
**Alert class:** standard
**Change summary:** New PharmGKB clinical annotation level observed: 3.
**Detector trigger:** Tracked variant gained a PharmGKB clinical annotation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** pharmgkb
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-11T01:31:10Z | pharmgkb | neuro_pharmacogenomics|rs1057910|genotypes|A%2CC

**Entry ID:** pharmgkb-4fb32107be24a947
**Alert class:** standard
**Change summary:** New PharmGKB clinical annotation level observed: 3.
**Detector trigger:** Tracked variant gained a PharmGKB clinical annotation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** pharmgkb
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-11T01:31:10Z | pharmgkb | neuro_pharmacogenomics|rs1057910|genotypes|A%2CA

**Entry ID:** pharmgkb-dcfd44c69838cc0b
**Alert class:** standard
**Change summary:** New PharmGKB clinical annotation level observed: 3.
**Detector trigger:** Tracked variant gained a PharmGKB clinical annotation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** pharmgkb
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-11T01:31:10Z | pharmgkb | neuro_pharmacogenomics|rs1057910|insights|C%2CC

**Entry ID:** pharmgkb-cbe87f342f88dec0
**Alert class:** standard
**Change summary:** New PharmGKB clinical annotation level observed: 3.
**Detector trigger:** Tracked variant gained a PharmGKB clinical annotation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** pharmgkb
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-11T01:31:10Z | pharmgkb | neuro_pharmacogenomics|rs1057910|insights|A%2CC

**Entry ID:** pharmgkb-44e365f54b15c03a
**Alert class:** standard
**Change summary:** New PharmGKB clinical annotation level observed: 3.
**Detector trigger:** Tracked variant gained a PharmGKB clinical annotation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** pharmgkb
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-11T01:31:10Z | pharmgkb | neuro_pharmacogenomics|rs1057910|insights|A%2CA

**Entry ID:** pharmgkb-a416419b3bfee1c2
**Alert class:** standard
**Change summary:** New PharmGKB clinical annotation level observed: 3.
**Detector trigger:** Tracked variant gained a PharmGKB clinical annotation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** pharmgkb
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-11T01:31:10Z | pharmgkb | neuro_pharmacogenomics|rs12248560|genotypes|T%2CT

**Entry ID:** pharmgkb-8d0e8e8041082ca8
**Alert class:** standard
**Change summary:** New PharmGKB clinical annotation level observed: 3.
**Detector trigger:** Tracked variant gained a PharmGKB clinical annotation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** pharmgkb
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-11T01:31:10Z | pharmgkb | neuro_pharmacogenomics|rs12248560|genotypes|C%2CT

**Entry ID:** pharmgkb-7771e06bf393c649
**Alert class:** standard
**Change summary:** New PharmGKB clinical annotation level observed: 3.
**Detector trigger:** Tracked variant gained a PharmGKB clinical annotation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** pharmgkb
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-11T01:31:10Z | pharmgkb | neuro_pharmacogenomics|rs12248560|genotypes|C%2CC

**Entry ID:** pharmgkb-7abe620e3b4ab5d3
**Alert class:** standard
**Change summary:** New PharmGKB clinical annotation level observed: 3.
**Detector trigger:** Tracked variant gained a PharmGKB clinical annotation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** pharmgkb
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-11T01:31:10Z | pharmgkb | cardiovascular_lipid|rs9923231|genotypes|T%2CT

**Entry ID:** pharmgkb-4a1f3d9c987e2fd2
**Alert class:** standard
**Change summary:** New PharmGKB clinical annotation level observed: 1A.
**Detector trigger:** Tracked variant gained a PharmGKB clinical annotation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** pharmgkb
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-11T01:31:10Z | pharmgkb | cardiovascular_lipid|rs9923231|genotypes|C%2CT

**Entry ID:** pharmgkb-8fcf8053e0630a07
**Alert class:** standard
**Change summary:** New PharmGKB clinical annotation level observed: 1A.
**Detector trigger:** Tracked variant gained a PharmGKB clinical annotation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** pharmgkb
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-11T01:31:10Z | pharmgkb | cardiovascular_lipid|rs9923231|genotypes|C%2CC

**Entry ID:** pharmgkb-6a3f6f42578184c1
**Alert class:** standard
**Change summary:** New PharmGKB clinical annotation level observed: 1A.
**Detector trigger:** Tracked variant gained a PharmGKB clinical annotation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** pharmgkb
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-11T01:31:10Z | pharmgkb | cardiovascular_lipid|rs9923231|insights|T%2CT

**Entry ID:** pharmgkb-ff1f36ab5a548af8
**Alert class:** standard
**Change summary:** New PharmGKB clinical annotation level observed: 1A.
**Detector trigger:** Tracked variant gained a PharmGKB clinical annotation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** pharmgkb
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-11T01:31:10Z | pharmgkb | cardiovascular_lipid|rs9923231|insights|C%2CT

**Entry ID:** pharmgkb-45b83595b59f7097
**Alert class:** standard
**Change summary:** New PharmGKB clinical annotation level observed: 1A.
**Detector trigger:** Tracked variant gained a PharmGKB clinical annotation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** pharmgkb
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-11T01:31:10Z | pharmgkb | cardiovascular_lipid|rs9923231|insights|C%2CC

**Entry ID:** pharmgkb-bde86b260bb3b9df
**Alert class:** standard
**Change summary:** New PharmGKB clinical annotation level observed: 1A.
**Detector trigger:** Tracked variant gained a PharmGKB clinical annotation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** pharmgkb
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-11T01:31:10Z | pharmgkb | cardiovascular_lipid|rs4149056|genotypes|C%2CC

**Entry ID:** pharmgkb-21c57effb7cd8aaa
**Alert class:** standard
**Change summary:** New PharmGKB clinical annotation level observed: 1A.
**Detector trigger:** Tracked variant gained a PharmGKB clinical annotation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** pharmgkb
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-11T01:31:10Z | pharmgkb | cardiovascular_lipid|rs4149056|genotypes|T%2CC

**Entry ID:** pharmgkb-9da5e654ddd0700e
**Alert class:** standard
**Change summary:** New PharmGKB clinical annotation level observed: 1A.
**Detector trigger:** Tracked variant gained a PharmGKB clinical annotation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** pharmgkb
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-11T01:31:10Z | pharmgkb | cardiovascular_lipid|rs4149056|genotypes|T%2CT

**Entry ID:** pharmgkb-cc9ac2159499f074
**Alert class:** standard
**Change summary:** New PharmGKB clinical annotation level observed: 1A.
**Detector trigger:** Tracked variant gained a PharmGKB clinical annotation.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** pharmgkb
**Rule invoked:** N/A
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:49:12Z | algorithmic_editorial_grader | methylation_detox|rs1801131|genotypes|G%2CG

**Entry ID:** algorithmic_editorial_grader-17aca18134751b20
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1801131 (MTHFR (A1298C)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:49:11Z | algorithmic_editorial_grader | methylation_detox|rs1801131|genotypes|T%2CG

**Entry ID:** algorithmic_editorial_grader-6d8a01fc2ba691b0
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1801131 (MTHFR (A1298C)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:49:11Z | algorithmic_editorial_grader | methylation_detox|rs1801131|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-54d335b7b55cfa11
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1801131 (MTHFR (A1298C)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:49:11Z | algorithmic_editorial_grader | methylation_detox|rs1801131|insights|C%2CC

**Entry ID:** algorithmic_editorial_grader-8e973868ba787256
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1801131 (MTHFR (A1298C)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:49:11Z | algorithmic_editorial_grader | methylation_detox|rs1801131|insights|A%2CC

**Entry ID:** algorithmic_editorial_grader-145b7e4fa87c7e3f
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1801131 (MTHFR (A1298C)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:49:11Z | algorithmic_editorial_grader | methylation_detox|rs1801131|insights|A%2CA

**Entry ID:** algorithmic_editorial_grader-49f3de12e75fb3ac
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1801131 (MTHFR (A1298C)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:49:02Z | algorithmic_editorial_grader | longevity_telomere|rs564481|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-5defe59f57e3edb2
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs564481 (KL).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:49:02Z | algorithmic_editorial_grader | longevity_telomere|rs564481|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-e684636e68987343
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs564481 (KL).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:49:02Z | algorithmic_editorial_grader | longevity_telomere|rs564481|genotypes|T%2CC

**Entry ID:** algorithmic_editorial_grader-6143b63a4ce67b1c
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs564481 (KL).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:49:01Z | algorithmic_editorial_grader | longevity_telomere|rs564481|genotypes|T%2CC

**Entry ID:** algorithmic_editorial_grader-c4816f143d2e93aa
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs564481 (KL).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:49:01Z | algorithmic_editorial_grader | longevity_telomere|rs564481|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-8992eab286d4952e
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs564481 (KL).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:49:01Z | algorithmic_editorial_grader | longevity_telomere|rs564481|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-cd673d54fc1169f6
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs564481 (KL).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:49:01Z | algorithmic_editorial_grader | longevity_telomere|rs564481|insights|G%2CG

**Entry ID:** algorithmic_editorial_grader-f11f9fd04271bdfd
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs564481 (KL).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:49:01Z | algorithmic_editorial_grader | longevity_telomere|rs564481|insights|G%2CG

**Entry ID:** algorithmic_editorial_grader-28e64de9ad4b4680
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs564481 (KL).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:49:01Z | algorithmic_editorial_grader | longevity_telomere|rs564481|insights|A%2CG

**Entry ID:** algorithmic_editorial_grader-a294da0f69ee0a84
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs564481 (KL).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:49:01Z | algorithmic_editorial_grader | longevity_telomere|rs564481|insights|A%2CG

**Entry ID:** algorithmic_editorial_grader-90965a9ab36fcd24
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs564481 (KL).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:49:01Z | algorithmic_editorial_grader | longevity_telomere|rs564481|insights|A%2CA

**Entry ID:** algorithmic_editorial_grader-284129a3f5370212
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs564481 (KL).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:49:01Z | algorithmic_editorial_grader | longevity_telomere|rs564481|insights|A%2CA

**Entry ID:** algorithmic_editorial_grader-9fc3921a5100bfa0
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs564481 (KL).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:58Z | algorithmic_editorial_grader | longevity_telomere|rs9527025|genotypes|G%2CG

**Entry ID:** algorithmic_editorial_grader-e3b22cd50c49272b
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9527025 (KL).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:58Z | algorithmic_editorial_grader | longevity_telomere|rs9527025|genotypes|G%2CG

**Entry ID:** algorithmic_editorial_grader-681f5f47513a0c36
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9527025 (KL).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:58Z | algorithmic_editorial_grader | longevity_telomere|rs9527025|genotypes|A%2CG

**Entry ID:** algorithmic_editorial_grader-c14c8c16f8d9cd2d
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9527025 (KL).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:58Z | algorithmic_editorial_grader | longevity_telomere|rs9527025|genotypes|A%2CG

**Entry ID:** algorithmic_editorial_grader-1aca4a4d38ec0474
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9527025 (KL).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:58Z | algorithmic_editorial_grader | longevity_telomere|rs9527025|genotypes|A%2CA

**Entry ID:** algorithmic_editorial_grader-616626564682dff9
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9527025 (KL).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:58Z | algorithmic_editorial_grader | longevity_telomere|rs9527025|genotypes|A%2CA

**Entry ID:** algorithmic_editorial_grader-9df6dfb3928335cc
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9527025 (KL).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:58Z | algorithmic_editorial_grader | longevity_telomere|rs9527025|insights|T%2CT

**Entry ID:** algorithmic_editorial_grader-bfc79c17723e1a90
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9527025 (KL).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:58Z | algorithmic_editorial_grader | longevity_telomere|rs9527025|insights|T%2CT

**Entry ID:** algorithmic_editorial_grader-899cc22d2fda058b
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9527025 (KL).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:58Z | algorithmic_editorial_grader | longevity_telomere|rs9527025|insights|C%2CT

**Entry ID:** algorithmic_editorial_grader-57776f971e6f9c44
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9527025 (KL).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:58Z | algorithmic_editorial_grader | longevity_telomere|rs9527025|insights|C%2CT

**Entry ID:** algorithmic_editorial_grader-93a0e3c7c79dad1e
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9527025 (KL).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:58Z | algorithmic_editorial_grader | longevity_telomere|rs9527025|insights|C%2CC

**Entry ID:** algorithmic_editorial_grader-bff363db9bd6ab30
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9527025 (KL).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:58Z | algorithmic_editorial_grader | longevity_telomere|rs9527025|insights|C%2CC

**Entry ID:** algorithmic_editorial_grader-12b84618b29871d3
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9527025 (KL).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:56Z | algorithmic_editorial_grader | longevity_telomere|rs9536314|genotypes|G%2CG

**Entry ID:** algorithmic_editorial_grader-b4e6512bd502cd73
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9536314 (KL).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:56Z | algorithmic_editorial_grader | longevity_telomere|rs9536314|genotypes|G%2CG

**Entry ID:** algorithmic_editorial_grader-2679cd84f1fb61ef
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9536314 (KL).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:56Z | algorithmic_editorial_grader | longevity_telomere|rs9536314|genotypes|T%2CG

**Entry ID:** algorithmic_editorial_grader-ad3fbc718b7b409d
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9536314 (KL).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:55Z | algorithmic_editorial_grader | longevity_telomere|rs9536314|genotypes|T%2CG

**Entry ID:** algorithmic_editorial_grader-128b2eb69b02225e
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9536314 (KL).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:55Z | algorithmic_editorial_grader | longevity_telomere|rs9536314|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-96fdf3b3fa2338f6
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9536314 (KL).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:55Z | algorithmic_editorial_grader | longevity_telomere|rs9536314|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-619e143be07bb57e
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9536314 (KL).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:55Z | algorithmic_editorial_grader | longevity_telomere|rs9536314|insights|G%2CG

**Entry ID:** algorithmic_editorial_grader-ca2e80a6c3c7eb93
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9536314 (KL).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:55Z | algorithmic_editorial_grader | longevity_telomere|rs9536314|insights|G%2CG

**Entry ID:** algorithmic_editorial_grader-9538f1292988b672
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9536314 (KL).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:55Z | algorithmic_editorial_grader | longevity_telomere|rs9536314|insights|C%2CG

**Entry ID:** algorithmic_editorial_grader-cb6fdcce788f78c1
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9536314 (KL).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:55Z | algorithmic_editorial_grader | longevity_telomere|rs9536314|insights|C%2CG

**Entry ID:** algorithmic_editorial_grader-e21a92238afe9574
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9536314 (KL).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:55Z | algorithmic_editorial_grader | longevity_telomere|rs9536314|insights|C%2CC

**Entry ID:** algorithmic_editorial_grader-a3d1f640a252dd42
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9536314 (KL).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:55Z | algorithmic_editorial_grader | longevity_telomere|rs9536314|insights|C%2CC

**Entry ID:** algorithmic_editorial_grader-72c6eca0b90a54c8
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs9536314 (KL).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:51Z | algorithmic_editorial_grader | longevity_telomere|rs10936599|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-071d9767a6ae157a
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs10936599 (TERC (telomerase RNA component)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:51Z | algorithmic_editorial_grader | longevity_telomere|rs10936599|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-f96b4479bd86b3bd
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs10936599 (TERC (telomerase RNA component)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:51Z | algorithmic_editorial_grader | longevity_telomere|rs10936599|genotypes|T%2CC

**Entry ID:** algorithmic_editorial_grader-62f8fd0368ee8945
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs10936599 (TERC (telomerase RNA component)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:51Z | algorithmic_editorial_grader | longevity_telomere|rs10936599|genotypes|T%2CC

**Entry ID:** algorithmic_editorial_grader-1a6fea4d53a337f2
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs10936599 (TERC (telomerase RNA component)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:51Z | algorithmic_editorial_grader | longevity_telomere|rs10936599|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-187f9e94bff21072
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs10936599 (TERC (telomerase RNA component)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:51Z | algorithmic_editorial_grader | longevity_telomere|rs10936599|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-303b200bdab24588
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs10936599 (TERC (telomerase RNA component)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:51Z | algorithmic_editorial_grader | longevity_telomere|rs10936599|insights|C%2CC

**Entry ID:** algorithmic_editorial_grader-57b6199143a08998
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs10936599 (TERC (telomerase RNA component)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:51Z | algorithmic_editorial_grader | longevity_telomere|rs10936599|insights|C%2CC

**Entry ID:** algorithmic_editorial_grader-3342fe68b258bd64
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs10936599 (TERC (telomerase RNA component)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:51Z | algorithmic_editorial_grader | longevity_telomere|rs10936599|insights|T%2CC

**Entry ID:** algorithmic_editorial_grader-0b62b4b1613ce72c
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs10936599 (TERC (telomerase RNA component)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:51Z | algorithmic_editorial_grader | longevity_telomere|rs10936599|insights|T%2CC

**Entry ID:** algorithmic_editorial_grader-84717734ae2ac607
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs10936599 (TERC (telomerase RNA component)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:51Z | algorithmic_editorial_grader | longevity_telomere|rs10936599|insights|T%2CT

**Entry ID:** algorithmic_editorial_grader-c822ff1efd16ca32
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs10936599 (TERC (telomerase RNA component)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:51Z | algorithmic_editorial_grader | longevity_telomere|rs10936599|insights|T%2CT

**Entry ID:** algorithmic_editorial_grader-21c6eced6d3251f2
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs10936599 (TERC (telomerase RNA component)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:43Z | algorithmic_editorial_grader | longevity_telomere|rs2253310|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-a5959c57fbedeabb
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2253310 (FOXO3 (longevity-associated)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:43Z | algorithmic_editorial_grader | longevity_telomere|rs2253310|genotypes|C%2CT

**Entry ID:** algorithmic_editorial_grader-0df27488cff708d2
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2253310 (FOXO3 (longevity-associated)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:43Z | algorithmic_editorial_grader | longevity_telomere|rs2253310|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-f5c1ada8ba72c899
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2253310 (FOXO3 (longevity-associated)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:43Z | algorithmic_editorial_grader | longevity_telomere|rs2253310|insights|T%2CT

**Entry ID:** algorithmic_editorial_grader-471c23a1b62e9b05
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2253310 (FOXO3 (longevity-associated)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:43Z | algorithmic_editorial_grader | longevity_telomere|rs2253310|insights|C%2CT

**Entry ID:** algorithmic_editorial_grader-716a26777b27fcee
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2253310 (FOXO3 (longevity-associated)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:43Z | algorithmic_editorial_grader | longevity_telomere|rs2253310|insights|C%2CC

**Entry ID:** algorithmic_editorial_grader-b13f5e7c01c7f09e
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2253310 (FOXO3 (longevity-associated)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:39Z | algorithmic_editorial_grader | longevity_telomere|rs4946936|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-ac14267c549834e7
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs4946936 (FOXO3 (longevity-associated)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:39Z | algorithmic_editorial_grader | longevity_telomere|rs4946936|genotypes|C%2CT

**Entry ID:** algorithmic_editorial_grader-b0a0ba25b91d1297
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs4946936 (FOXO3 (longevity-associated)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:39Z | algorithmic_editorial_grader | longevity_telomere|rs4946936|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-4c638a753e214877
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs4946936 (FOXO3 (longevity-associated)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:39Z | algorithmic_editorial_grader | longevity_telomere|rs4946936|insights|G%2CG

**Entry ID:** algorithmic_editorial_grader-f29f1ce4c56f2056
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs4946936 (FOXO3 (longevity-associated)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:39Z | algorithmic_editorial_grader | longevity_telomere|rs4946936|insights|A%2CG

**Entry ID:** algorithmic_editorial_grader-13c869a46f70385c
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs4946936 (FOXO3 (longevity-associated)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:39Z | algorithmic_editorial_grader | longevity_telomere|rs4946936|insights|A%2CA

**Entry ID:** algorithmic_editorial_grader-d5b8a6f5241faf27
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs4946936 (FOXO3 (longevity-associated)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:36Z | algorithmic_editorial_grader | longevity_telomere|rs2802292|genotypes|G%2CG

**Entry ID:** algorithmic_editorial_grader-ce9f020c43a11721
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2802292 (FOXO3 (longevity-associated)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:36Z | algorithmic_editorial_grader | longevity_telomere|rs2802292|genotypes|T%2CG

**Entry ID:** algorithmic_editorial_grader-12842ba77167436a
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2802292 (FOXO3 (longevity-associated)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:36Z | algorithmic_editorial_grader | longevity_telomere|rs2802292|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-7d43001640135350
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2802292 (FOXO3 (longevity-associated)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:36Z | algorithmic_editorial_grader | longevity_telomere|rs2802292|insights|G%2CG

**Entry ID:** algorithmic_editorial_grader-8cebb26362cacbad
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2802292 (FOXO3 (longevity-associated)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:35Z | algorithmic_editorial_grader | longevity_telomere|rs2802292|insights|G%2CT

**Entry ID:** algorithmic_editorial_grader-ca1765cea203afdc
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2802292 (FOXO3 (longevity-associated)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:35Z | algorithmic_editorial_grader | longevity_telomere|rs2802292|insights|T%2CT

**Entry ID:** algorithmic_editorial_grader-e8db16ad69233fe2
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2802292 (FOXO3 (longevity-associated)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:31Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1360780|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-1cd326a19a972f34
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1360780 (FKBP5 (stress response / HPA axis)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:31Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1360780|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-566e80f675990d75
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1360780 (FKBP5 (stress response / HPA axis)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:31Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1360780|genotypes|C%2CT

**Entry ID:** algorithmic_editorial_grader-5b20faeb6df01d8a
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1360780 (FKBP5 (stress response / HPA axis)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:31Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1360780|genotypes|C%2CT

**Entry ID:** algorithmic_editorial_grader-533cef300bb1e045
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1360780 (FKBP5 (stress response / HPA axis)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:31Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1360780|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-0a4d551f5823b1b7
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1360780 (FKBP5 (stress response / HPA axis)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:31Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1360780|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-67a0dbfdfb09e9f0
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1360780 (FKBP5 (stress response / HPA axis)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:31Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1360780|insights|T%2CT

**Entry ID:** algorithmic_editorial_grader-65c612f66e7781eb
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1360780 (FKBP5 (stress response / HPA axis)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:31Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1360780|insights|T%2CT

**Entry ID:** algorithmic_editorial_grader-8c8e335a75e5d43b
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1360780 (FKBP5 (stress response / HPA axis)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:31Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1360780|insights|C%2CT

**Entry ID:** algorithmic_editorial_grader-cff47bcd86b07f17
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1360780 (FKBP5 (stress response / HPA axis)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:31Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1360780|insights|C%2CT

**Entry ID:** algorithmic_editorial_grader-81df669d67b6128c
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1360780 (FKBP5 (stress response / HPA axis)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:31Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1360780|insights|C%2CC

**Entry ID:** algorithmic_editorial_grader-3d48fd868f114b79
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1360780 (FKBP5 (stress response / HPA axis)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:31Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1360780|insights|C%2CC

**Entry ID:** algorithmic_editorial_grader-93eec8246dac2054
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1360780 (FKBP5 (stress response / HPA axis)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:30Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1800497|genotypes|A%2CA

**Entry ID:** algorithmic_editorial_grader-f927b1919be1a113
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1800497 (ANKK1/DRD2 (Taq1A)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:29Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1800497|genotypes|A%2CA

**Entry ID:** algorithmic_editorial_grader-578a21f5a2bfe2b5
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1800497 (ANKK1/DRD2 (Taq1A)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:29Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1800497|genotypes|G%2CA

**Entry ID:** algorithmic_editorial_grader-19f4ddb923179388
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1800497 (ANKK1/DRD2 (Taq1A)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:29Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1800497|genotypes|G%2CA

**Entry ID:** algorithmic_editorial_grader-cce144fc7d137aaf
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1800497 (ANKK1/DRD2 (Taq1A)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:29Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1800497|genotypes|G%2CG

**Entry ID:** algorithmic_editorial_grader-571f2e1c6866b37c
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1800497 (ANKK1/DRD2 (Taq1A)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:29Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1800497|genotypes|G%2CG

**Entry ID:** algorithmic_editorial_grader-614b5c6b141bb072
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1800497 (ANKK1/DRD2 (Taq1A)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:29Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1800497|insights|T%2CT

**Entry ID:** algorithmic_editorial_grader-16f85a194b571a6d
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1800497 (ANKK1/DRD2 (Taq1A)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:29Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1800497|insights|T%2CT

**Entry ID:** algorithmic_editorial_grader-ebb7bc7f3069b948
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1800497 (ANKK1/DRD2 (Taq1A)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:29Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1800497|insights|C%2CT

**Entry ID:** algorithmic_editorial_grader-6652c5b6bd2a33ca
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1800497 (ANKK1/DRD2 (Taq1A)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:29Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1800497|insights|C%2CT

**Entry ID:** algorithmic_editorial_grader-683a4fe046850478
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1800497 (ANKK1/DRD2 (Taq1A)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:29Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1800497|insights|C%2CC

**Entry ID:** algorithmic_editorial_grader-f1f43a42022a8dec
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1800497 (ANKK1/DRD2 (Taq1A)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:29Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs1800497|insights|C%2CC

**Entry ID:** algorithmic_editorial_grader-cb8466997da2b3b1
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1800497 (ANKK1/DRD2 (Taq1A)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:26Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs2494732|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-dda540e0cadbbda3
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2494732 (AKT1).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:26Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs2494732|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-0b608f2be378b42a
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2494732 (AKT1).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:26Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs2494732|genotypes|C%2CT

**Entry ID:** algorithmic_editorial_grader-8245c7cde38dc877
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2494732 (AKT1).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:26Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs2494732|genotypes|C%2CT

**Entry ID:** algorithmic_editorial_grader-e37cf0fa7225dfed
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2494732 (AKT1).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:25Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs2494732|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-029bb8edf85ec675
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2494732 (AKT1).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:25Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs2494732|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-35baf305e128727f
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2494732 (AKT1).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:22Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs762551|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-c85367dff6ea209f
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs762551 (CYP1A2 (caffeine/drug metabolism)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:22Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs762551|genotypes|A%2CC

**Entry ID:** algorithmic_editorial_grader-7d6c2ca5cc156dde
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs762551 (CYP1A2 (caffeine/drug metabolism)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:22Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs762551|genotypes|A%2CA

**Entry ID:** algorithmic_editorial_grader-d485c0d49525a2c4
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs762551 (CYP1A2 (caffeine/drug metabolism)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:22Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs762551|insights|C%2CC

**Entry ID:** algorithmic_editorial_grader-88cd515ac5b1c97a
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs762551 (CYP1A2 (caffeine/drug metabolism)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:22Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs762551|insights|A%2CC

**Entry ID:** algorithmic_editorial_grader-01af97e4aa0fd8f9
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs762551 (CYP1A2 (caffeine/drug metabolism)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:21Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs762551|insights|A%2CA

**Entry ID:** algorithmic_editorial_grader-4eb6779cb02636ef
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs762551 (CYP1A2 (caffeine/drug metabolism)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:18Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs5751876|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-1db960dfb869dc21
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs5751876 (ADORA2A (A2A adenosine receptor)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:18Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs5751876|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-f3677a37732da7e2
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs5751876 (ADORA2A (A2A adenosine receptor)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:18Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs5751876|genotypes|T%2CC

**Entry ID:** algorithmic_editorial_grader-850310a68e305ac4
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs5751876 (ADORA2A (A2A adenosine receptor)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:18Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs5751876|genotypes|T%2CC

**Entry ID:** algorithmic_editorial_grader-2a1854b40a8a57c7
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs5751876 (ADORA2A (A2A adenosine receptor)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:18Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs5751876|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-6c28ee62ee48e6ea
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs5751876 (ADORA2A (A2A adenosine receptor)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:18Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs5751876|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-46608c238d3fd6aa
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs5751876 (ADORA2A (A2A adenosine receptor)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:18Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs5751876|insights|T%2CT

**Entry ID:** algorithmic_editorial_grader-c8c5d7ca19af7822
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs5751876 (ADORA2A (A2A adenosine receptor)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:18Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs5751876|insights|T%2CT

**Entry ID:** algorithmic_editorial_grader-887abe49c2c5064b
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs5751876 (ADORA2A (A2A adenosine receptor)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:18Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs5751876|insights|C%2CT

**Entry ID:** algorithmic_editorial_grader-722f93275735e61d
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs5751876 (ADORA2A (A2A adenosine receptor)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:18Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs5751876|insights|C%2CT

**Entry ID:** algorithmic_editorial_grader-26dfe8190054e00f
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs5751876 (ADORA2A (A2A adenosine receptor)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:17Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs5751876|insights|C%2CC

**Entry ID:** algorithmic_editorial_grader-24ad82a2145f161f
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs5751876 (ADORA2A (A2A adenosine receptor)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:17Z | algorithmic_editorial_grader | neuro_pharmacogenomics|rs5751876|insights|C%2CC

**Entry ID:** algorithmic_editorial_grader-3e29309afc2ee8b3
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs5751876 (ADORA2A (A2A adenosine receptor)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:09Z | algorithmic_editorial_grader | alzheimers_clearance|rs641120|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-c42012ed07be1c9a
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs641120 (SORL1).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:09Z | algorithmic_editorial_grader | alzheimers_clearance|rs641120|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-e1f408b9afce1ffc
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs641120 (SORL1).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:09Z | algorithmic_editorial_grader | alzheimers_clearance|rs641120|genotypes|C%2CT

**Entry ID:** algorithmic_editorial_grader-47d5d30695b50435
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs641120 (SORL1).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:09Z | algorithmic_editorial_grader | alzheimers_clearance|rs641120|genotypes|C%2CT

**Entry ID:** algorithmic_editorial_grader-28f62c21867304a1
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs641120 (SORL1).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:09Z | algorithmic_editorial_grader | alzheimers_clearance|rs641120|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-d4d5b013140aad0b
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs641120 (SORL1).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:09Z | algorithmic_editorial_grader | alzheimers_clearance|rs641120|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-649714dd3b16c7b3
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs641120 (SORL1).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:09Z | algorithmic_editorial_grader | alzheimers_clearance|rs641120|insights|C%2CC

**Entry ID:** algorithmic_editorial_grader-ce4188f53c1b94d4
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs641120 (SORL1).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:09Z | algorithmic_editorial_grader | alzheimers_clearance|rs641120|insights|C%2CC

**Entry ID:** algorithmic_editorial_grader-46125e6bf003fc41
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs641120 (SORL1).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:09Z | algorithmic_editorial_grader | alzheimers_clearance|rs641120|insights|C%2CT

**Entry ID:** algorithmic_editorial_grader-2b080104d559e376
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs641120 (SORL1).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:09Z | algorithmic_editorial_grader | alzheimers_clearance|rs641120|insights|C%2CT

**Entry ID:** algorithmic_editorial_grader-09022c143a5184e4
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs641120 (SORL1).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:09Z | algorithmic_editorial_grader | alzheimers_clearance|rs641120|insights|T%2CT

**Entry ID:** algorithmic_editorial_grader-e5684890a0a50c50
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs641120 (SORL1).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:09Z | algorithmic_editorial_grader | alzheimers_clearance|rs641120|insights|T%2CT

**Entry ID:** algorithmic_editorial_grader-add069d2fe1673f7
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs641120 (SORL1).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:03Z | algorithmic_editorial_grader | alzheimers_clearance|rs7561528|genotypes|G%2CG

**Entry ID:** algorithmic_editorial_grader-1bb00261cb9af4c0
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs7561528 (BIN1).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:03Z | algorithmic_editorial_grader | alzheimers_clearance|rs7561528|genotypes|A%2CG

**Entry ID:** algorithmic_editorial_grader-3c518623652b03e2
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs7561528 (BIN1).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:03Z | algorithmic_editorial_grader | alzheimers_clearance|rs7561528|genotypes|A%2CA

**Entry ID:** algorithmic_editorial_grader-10557150859d2d39
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs7561528 (BIN1).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:03Z | algorithmic_editorial_grader | alzheimers_clearance|rs7561528|insights|A%2CA

**Entry ID:** algorithmic_editorial_grader-b9e1f0a4293167c9
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs7561528 (BIN1).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:03Z | algorithmic_editorial_grader | alzheimers_clearance|rs7561528|insights|G%2CA

**Entry ID:** algorithmic_editorial_grader-5fc15ad4588849dd
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs7561528 (BIN1).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:48:03Z | algorithmic_editorial_grader | alzheimers_clearance|rs7561528|insights|G%2CG

**Entry ID:** algorithmic_editorial_grader-6b01ce5ba51f973a
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs7561528 (BIN1).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:55Z | algorithmic_editorial_grader | cardiovascular_lipid|rs174537|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-11e4f3dde75e13b5
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs174537 (FADS1 (fatty acid desaturase 1)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:55Z | algorithmic_editorial_grader | cardiovascular_lipid|rs174537|genotypes|G%2CT

**Entry ID:** algorithmic_editorial_grader-3678b8058f942f24
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs174537 (FADS1 (fatty acid desaturase 1)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:55Z | algorithmic_editorial_grader | cardiovascular_lipid|rs174537|genotypes|G%2CG

**Entry ID:** algorithmic_editorial_grader-3b5f7d6a2ed64ae9
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs174537 (FADS1 (fatty acid desaturase 1)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:55Z | algorithmic_editorial_grader | cardiovascular_lipid|rs174537|insights|T%2CT

**Entry ID:** algorithmic_editorial_grader-2cd15fc1d5913b80
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs174537 (FADS1 (fatty acid desaturase 1)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:55Z | algorithmic_editorial_grader | cardiovascular_lipid|rs174537|insights|G%2CT

**Entry ID:** algorithmic_editorial_grader-7df30b2981646579
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs174537 (FADS1 (fatty acid desaturase 1)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:55Z | algorithmic_editorial_grader | cardiovascular_lipid|rs174537|insights|G%2CG

**Entry ID:** algorithmic_editorial_grader-ad942bd3d6f4c460
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs174537 (FADS1 (fatty acid desaturase 1)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:35Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1799963|genotypes|A%2CA

**Entry ID:** algorithmic_editorial_grader-181a989bb5b27b7c
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1799963 (F2 / Prothrombin G20210A).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:35Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1799963|genotypes|G%2CA

**Entry ID:** algorithmic_editorial_grader-bac93da88679d21a
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1799963 (F2 / Prothrombin G20210A).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:35Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1799963|genotypes|G%2CG

**Entry ID:** algorithmic_editorial_grader-b53469fe2f1e1426
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1799963 (F2 / Prothrombin G20210A).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:35Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1799963|insights|A%2CA

**Entry ID:** algorithmic_editorial_grader-799ec08addf57ac6
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1799963 (F2 / Prothrombin G20210A).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:35Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1799963|insights|G%2CA

**Entry ID:** algorithmic_editorial_grader-24ea831521202999
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1799963 (F2 / Prothrombin G20210A).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:35Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1799963|insights|G%2CG

**Entry ID:** algorithmic_editorial_grader-148af119b14bb834
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1799963 (F2 / Prothrombin G20210A).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:32Z | algorithmic_editorial_grader | cardiovascular_lipid|rs6025|genotypes|A%2CA

**Entry ID:** algorithmic_editorial_grader-349c1441f23fa954
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs6025 (F5 / Factor V Leiden).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:32Z | algorithmic_editorial_grader | cardiovascular_lipid|rs6025|genotypes|A%2CA

**Entry ID:** algorithmic_editorial_grader-45671b727b6aff08
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs6025 (F5 / Factor V Leiden).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:32Z | algorithmic_editorial_grader | cardiovascular_lipid|rs6025|genotypes|G%2CA

**Entry ID:** algorithmic_editorial_grader-b972587eb0a76b81
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs6025 (F5 / Factor V Leiden).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:32Z | algorithmic_editorial_grader | cardiovascular_lipid|rs6025|genotypes|G%2CA

**Entry ID:** algorithmic_editorial_grader-9e3470f1a5f12955
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs6025 (F5 / Factor V Leiden).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:32Z | algorithmic_editorial_grader | cardiovascular_lipid|rs6025|genotypes|G%2CG

**Entry ID:** algorithmic_editorial_grader-f25a7728d3b8e309
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs6025 (F5 / Factor V Leiden).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:32Z | algorithmic_editorial_grader | cardiovascular_lipid|rs6025|genotypes|G%2CG

**Entry ID:** algorithmic_editorial_grader-fcffc7565db95408
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs6025 (F5 / Factor V Leiden).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:32Z | algorithmic_editorial_grader | cardiovascular_lipid|rs6025|insights|A%2CA

**Entry ID:** algorithmic_editorial_grader-ec1ae1131a0a7f5e
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs6025 (F5 / Factor V Leiden).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:32Z | algorithmic_editorial_grader | cardiovascular_lipid|rs6025|insights|A%2CA

**Entry ID:** algorithmic_editorial_grader-61d48527c2a85e5a
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs6025 (F5 / Factor V Leiden).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:32Z | algorithmic_editorial_grader | cardiovascular_lipid|rs6025|insights|G%2CA

**Entry ID:** algorithmic_editorial_grader-ae676d3dc8fab915
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs6025 (F5 / Factor V Leiden).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:32Z | algorithmic_editorial_grader | cardiovascular_lipid|rs6025|insights|G%2CA

**Entry ID:** algorithmic_editorial_grader-874c052928898f9f
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs6025 (F5 / Factor V Leiden).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:32Z | algorithmic_editorial_grader | cardiovascular_lipid|rs6025|insights|G%2CG

**Entry ID:** algorithmic_editorial_grader-f0d8509415591248
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs6025 (F5 / Factor V Leiden).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:32Z | algorithmic_editorial_grader | cardiovascular_lipid|rs6025|insights|G%2CG

**Entry ID:** algorithmic_editorial_grader-68356ea90f87a013
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs6025 (F5 / Factor V Leiden).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:27Z | algorithmic_editorial_grader | cardiovascular_lipid|rs2070744|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-d95eb10e1e4facdf
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2070744 (NOS3 / eNOS (promoter -786T/C)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:27Z | algorithmic_editorial_grader | cardiovascular_lipid|rs2070744|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-ff109944853f1494
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2070744 (NOS3 / eNOS (promoter -786T/C)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:27Z | algorithmic_editorial_grader | cardiovascular_lipid|rs2070744|genotypes|T%2CC

**Entry ID:** algorithmic_editorial_grader-ac2604d7f71552c9
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2070744 (NOS3 / eNOS (promoter -786T/C)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:27Z | algorithmic_editorial_grader | cardiovascular_lipid|rs2070744|genotypes|T%2CC

**Entry ID:** algorithmic_editorial_grader-a4e91ca3f3ce341e
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2070744 (NOS3 / eNOS (promoter -786T/C)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:27Z | algorithmic_editorial_grader | cardiovascular_lipid|rs2070744|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-dea1fba1a500cde3
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2070744 (NOS3 / eNOS (promoter -786T/C)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:27Z | algorithmic_editorial_grader | cardiovascular_lipid|rs2070744|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-2a42c9a21e8ef65d
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2070744 (NOS3 / eNOS (promoter -786T/C)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:27Z | algorithmic_editorial_grader | cardiovascular_lipid|rs2070744|insights|C%2CC

**Entry ID:** algorithmic_editorial_grader-79d03d4b0da27b50
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2070744 (NOS3 / eNOS (promoter -786T/C)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:27Z | algorithmic_editorial_grader | cardiovascular_lipid|rs2070744|insights|C%2CC

**Entry ID:** algorithmic_editorial_grader-abd15f5f509730aa
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2070744 (NOS3 / eNOS (promoter -786T/C)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:27Z | algorithmic_editorial_grader | cardiovascular_lipid|rs2070744|insights|T%2CC

**Entry ID:** algorithmic_editorial_grader-1779db8eae4ade37
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2070744 (NOS3 / eNOS (promoter -786T/C)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:27Z | algorithmic_editorial_grader | cardiovascular_lipid|rs2070744|insights|T%2CC

**Entry ID:** algorithmic_editorial_grader-e3aecba9fb6beb18
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2070744 (NOS3 / eNOS (promoter -786T/C)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:27Z | algorithmic_editorial_grader | cardiovascular_lipid|rs2070744|insights|T%2CT

**Entry ID:** algorithmic_editorial_grader-32d3f53bec3a9147
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2070744 (NOS3 / eNOS (promoter -786T/C)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:27Z | algorithmic_editorial_grader | cardiovascular_lipid|rs2070744|insights|T%2CT

**Entry ID:** algorithmic_editorial_grader-e7283960f85dd80b
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs2070744 (NOS3 / eNOS (promoter -786T/C)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:23Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1799983|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-49d7d16a4d2cdd0d
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1799983 (NOS3 / eNOS (Glu298Asp)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:23Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1799983|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-f62bac27bbd9a1ef
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1799983 (NOS3 / eNOS (Glu298Asp)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:23Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1799983|genotypes|G%2CT

**Entry ID:** algorithmic_editorial_grader-b996fc5dce30f337
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1799983 (NOS3 / eNOS (Glu298Asp)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:23Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1799983|genotypes|G%2CT

**Entry ID:** algorithmic_editorial_grader-543e3f9e4367b8ca
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1799983 (NOS3 / eNOS (Glu298Asp)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:23Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1799983|genotypes|G%2CG

**Entry ID:** algorithmic_editorial_grader-0d2387f832638749
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1799983 (NOS3 / eNOS (Glu298Asp)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:23Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1799983|genotypes|G%2CG

**Entry ID:** algorithmic_editorial_grader-42135b4ce3df7b4b
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1799983 (NOS3 / eNOS (Glu298Asp)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:23Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1799983|insights|T%2CT

**Entry ID:** algorithmic_editorial_grader-b29d6b114aa29e42
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1799983 (NOS3 / eNOS (Glu298Asp)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:23Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1799983|insights|T%2CT

**Entry ID:** algorithmic_editorial_grader-834d6ca9225f9d16
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1799983 (NOS3 / eNOS (Glu298Asp)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:23Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1799983|insights|G%2CT

**Entry ID:** algorithmic_editorial_grader-aeee9dfcb3615f11
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1799983 (NOS3 / eNOS (Glu298Asp)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:23Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1799983|insights|G%2CT

**Entry ID:** algorithmic_editorial_grader-46c31dd90a82bacf
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1799983 (NOS3 / eNOS (Glu298Asp)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:23Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1799983|insights|G%2CG

**Entry ID:** algorithmic_editorial_grader-b800a1e2e1e7d1c2
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1799983 (NOS3 / eNOS (Glu298Asp)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:23Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1799983|insights|G%2CG

**Entry ID:** algorithmic_editorial_grader-05b3517f1e8e4495
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1799983 (NOS3 / eNOS (Glu298Asp)).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:19Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1333049|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-b7dffcbac18ebf03
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1333049 (CDKN2B-AS1).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:18Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1333049|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-0a13bc1e0ec7ad96
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1333049 (CDKN2B-AS1).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:18Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1333049|genotypes|G%2CC

**Entry ID:** algorithmic_editorial_grader-b1bea215ad26e817
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1333049 (CDKN2B-AS1).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:18Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1333049|genotypes|G%2CC

**Entry ID:** algorithmic_editorial_grader-5a518099aa7f4461
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1333049 (CDKN2B-AS1).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:18Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1333049|genotypes|G%2CG

**Entry ID:** algorithmic_editorial_grader-8c9e0c4b18da1cf6
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1333049 (CDKN2B-AS1).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:18Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1333049|genotypes|G%2CG

**Entry ID:** algorithmic_editorial_grader-b0b1536ad4ea2a47
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1333049 (CDKN2B-AS1).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:18Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1333049|insights|C%2CC

**Entry ID:** algorithmic_editorial_grader-d823c21799a4b8c8
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1333049 (CDKN2B-AS1).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:18Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1333049|insights|C%2CC

**Entry ID:** algorithmic_editorial_grader-ead4096673d9cc7a
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1333049 (CDKN2B-AS1).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:18Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1333049|insights|G%2CC

**Entry ID:** algorithmic_editorial_grader-35369b501ed23494
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1333049 (CDKN2B-AS1).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:18Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1333049|insights|G%2CC

**Entry ID:** algorithmic_editorial_grader-b330b5e862a1fb81
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1333049 (CDKN2B-AS1).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:18Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1333049|insights|G%2CG

**Entry ID:** algorithmic_editorial_grader-4731a3eabd3a4b41
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1333049 (CDKN2B-AS1).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:18Z | algorithmic_editorial_grader | cardiovascular_lipid|rs1333049|insights|G%2CG

**Entry ID:** algorithmic_editorial_grader-91094f83ad84cbed
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs1333049 (CDKN2B-AS1).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:14Z | algorithmic_editorial_grader | cardiovascular_lipid|rs3798220|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-7e5b73d80abfef76
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs3798220 (LPA).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:14Z | algorithmic_editorial_grader | cardiovascular_lipid|rs3798220|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-abd1d56e842589ae
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs3798220 (LPA).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:14Z | algorithmic_editorial_grader | cardiovascular_lipid|rs3798220|genotypes|C%2CT

**Entry ID:** algorithmic_editorial_grader-601dcc25484ac593
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs3798220 (LPA).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:14Z | algorithmic_editorial_grader | cardiovascular_lipid|rs3798220|genotypes|C%2CT

**Entry ID:** algorithmic_editorial_grader-7f0140262371f245
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs3798220 (LPA).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:14Z | algorithmic_editorial_grader | cardiovascular_lipid|rs3798220|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-dc1d19ef8d851c59
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs3798220 (LPA).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:13Z | algorithmic_editorial_grader | cardiovascular_lipid|rs3798220|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-e8ae55eb96704a02
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs3798220 (LPA).
**Detector trigger:** Effect direction extraction confidence is below 50 percent.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-low-direction-extraction
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:11Z | algorithmic_editorial_grader | cardiovascular_lipid|rs10455872|genotypes|G%2CG

**Entry ID:** algorithmic_editorial_grader-2effd375b40cfabf
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs10455872 (LPA).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:11Z | algorithmic_editorial_grader | cardiovascular_lipid|rs10455872|genotypes|A%2CG

**Entry ID:** algorithmic_editorial_grader-d5bf886daa42846e
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs10455872 (LPA).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:47:11Z | algorithmic_editorial_grader | cardiovascular_lipid|rs10455872|genotypes|A%2CA

**Entry ID:** algorithmic_editorial_grader-ae96c992f53805d9
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs10455872 (LPA).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:46:42Z | algorithmic_editorial_grader | apoe_alzheimers|rs7412|genotypes|T%2CT

**Entry ID:** algorithmic_editorial_grader-7a117133455ed802
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs7412 (APOE (codon 158)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:46:42Z | algorithmic_editorial_grader | apoe_alzheimers|rs7412|genotypes|C%2CT

**Entry ID:** algorithmic_editorial_grader-14f7d5d37351d478
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs7412 (APOE (codon 158)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-07T03:46:42Z | algorithmic_editorial_grader | apoe_alzheimers|rs7412|genotypes|C%2CC

**Entry ID:** algorithmic_editorial_grader-a811c7dc301b97dc
**Alert class:** algorithm_default_applied
**Change summary:** Algorithm could not confidently grade rs7412 (APOE (codon 158)).
**Detector trigger:** Risk-modifier feature vector does not map cleanly to a VEGS strength label.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** algorithmic_grader_v1_1
**Rule invoked:** risk-ambiguous-thresholds
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false

## 2026-06-01T21:04:16Z | api_freshness_smoke | operational|monthly_api_smoke

**Entry ID:** api_freshness_smoke-b646f6e772a8ff2d
**Alert class:** standard
**Change summary:** Monthly API freshness smoke failed for external providers. Failures: semantic_scholar (PMID:9343467): HTTP 429 for https://api.semanticscholar.org/graph/v1/paper/PMID:9343467?fields=paperId%2Ctitle%2Cyear%2Cauthors%2CexternalIds%2CcitationCount%2CreferenceCount
**Detector trigger:** Scheduled HTTP probe for PharmGKB, OpenTargets, and Semantic Scholar.
**Editor action:** PENDING
**Action rationale:** PENDING
**SLA status:** open 0 days
**Auto-downgrade applied:** false
**Auto-downgrade reversed:** N/A
**Authority source:** sprint_50_api_smoke
**Rule invoked:** vegs_section_10_api_freshness_smoke
**Override resolution status:** N/A
**Alert resolution criteria:** authority_data_reviewed=false; schema_updates_applied=false; rationale_logged=false; historical_interpretations_archived_if_applicable=false